Neurodevelopmental outcomes of singleton large for gestational age infants <29 weeks’ gestation: a retrospective cohort study

on behalf of the Canadian Neonatal Network and the Canadian Neonatal Follow-Up Program

doi:10.1038/s41372-021-01080-z

Neurodevelopmental outcomes of singleton large for gestational age infants <29 weeks’ gestation: a retrospective cohort study

on behalf of the Canadian Neonatal Network and the Canadian Neonatal Follow-Up Program

Résultat de recherche: Article › examen par les pairs

6 Citations (Scopus)

Résumé

Objective: To compare neurodevelopmental outcomes of large and appropriate for gestational age (LGA, AGA) infants <29 weeks’ gestation at 18–24 months of corrected age. Study design: Retrospective cohort study using the Canadian Neonatal Network and Canadian Neonatal Follow-Up Network databases. Primary outcome was a composite of death or significant neurodevelopmental impairment (NDI), defined as severe cerebral palsy, Bayley III cognitive, language and motor scores of <70, need for hearing aids or cochlear implant and bilateral visual impairment. Univariate and multivariable logistic analyses were applied for outcomes. Results: The study cohort comprised 170 LGA and 1738 AGA infants. There was no difference in significant NDI or individual components of the Bayley III between LGA and AGA groups. LGA was associated with the increased risk of death by follow-up, 44/170 (25.9%) vs. 320/1738 (18.4%) (aOR: 1.60 95% CI: 1.00–2.54). Conclusions: Risk of NDI was similar between LGA and AGA infants.

Langue d'origine	English
Pages (de-à)	1313-1321
Nombre de pages	9
Journal	Journal of Perinatology
Volume	41
Numéro de publication	6
DOI	https://doi.org/10.1038/s41372-021-01080-z
Statut de publication	Published - juin 2021
Publié à l'externe	Oui

Note bibliographique

Funding Information:
Funding Although no specific funding was received for this study, organizational support for the Canadian Neonatal Network and the Canadian Neonatal Follow-Up Network was provided by the Maternal-infant Care Research Centre (MiCare) at Mount Sinai Hospital in Toronto, Ontario, Canada. MiCare is supported by a Canadian Institutes of Health Research (CIHR) Team Grant (CTP 87518), the Ontario Ministry of Health and Long-Term Care, and the participating hospitals. PSS holds a CIHR Applied Research Chair in Reproductive and Child Health Services and Policy Research (APR-126340).

Publisher Copyright:
© 2021, The Author(s), under exclusive licence to Springer Nature America, Inc.

ASJC Scopus Subject Areas

Pediatrics, Perinatology, and Child Health
Obstetrics and Gynaecology

PubMed: MeSH publication types

Journal Article
Research Support, Non-U.S. Gov't

ODD de l’ONU

Cette action contribue à la réalisation des objectifs de développement durable suivants

Accès au document

10.1038/s41372-021-01080-z

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@article{09bd4308d0fd40f3bd0ff1fa68632ef5,

title = "Neurodevelopmental outcomes of singleton large for gestational age infants <29 weeks{\textquoteright} gestation: a retrospective cohort study",

abstract = "Objective: To compare neurodevelopmental outcomes of large and appropriate for gestational age (LGA, AGA) infants <29 weeks{\textquoteright} gestation at 18–24 months of corrected age. Study design: Retrospective cohort study using the Canadian Neonatal Network and Canadian Neonatal Follow-Up Network databases. Primary outcome was a composite of death or significant neurodevelopmental impairment (NDI), defined as severe cerebral palsy, Bayley III cognitive, language and motor scores of <70, need for hearing aids or cochlear implant and bilateral visual impairment. Univariate and multivariable logistic analyses were applied for outcomes. Results: The study cohort comprised 170 LGA and 1738 AGA infants. There was no difference in significant NDI or individual components of the Bayley III between LGA and AGA groups. LGA was associated with the increased risk of death by follow-up, 44/170 (25.9%) vs. 320/1738 (18.4%) (aOR: 1.60 95% CI: 1.00–2.54). Conclusions: Risk of NDI was similar between LGA and AGA infants.",

author = "{on behalf of the Canadian Neonatal Network and the Canadian Neonatal Follow-Up Program} and Deepika Rustogi and Anne Synnes and Belal Alshaikh and Shabih Hasan and Christine Drolet and Edith Masse and Prashanth Murthy and Shah, {Prakesh S.} and Kamran Yusuf and Shah, {Prakesh S.} and Marc Beltempo and Jaideep Kanungo and Joseph Ting and Mehrem, {Ayman Abou} and Jennifer Toye and Khalid Aziz and Jaya Bodani and Lannae Strueby and Mary Seshia and Deepak Louis and Ruben Alvaro and Amit Mukerji and {Da Silva}, Orlando and Sajit Augustine and Lee, {Kyong Soon} and Eugene Ng and Brigitte Lemyre and Thierry Daboval and Faiza Khurshid and Victoria Bizgu and Keith Barrington and Christine Drolet and Bruno Piedboeuf and Martine Claveau and Valerie Bertelle and Edith Masse and Roderick Canning and Hala Makary and Cecil Ojah and Luis Monterrosa and Julie Emberley and Jehier Afifi and Andrzej Kajetanowicz and Lee, {Shoo K.} and Thevanisha Pillay and Leonora Hendson and Amber Reichert and Matthew Hicks and {de Cabo}, Cecilia and Chukwuma Nwaesei",

note = "Funding Information: Funding Although no specific funding was received for this study, organizational support for the Canadian Neonatal Network and the Canadian Neonatal Follow-Up Network was provided by the Maternal-infant Care Research Centre (MiCare) at Mount Sinai Hospital in Toronto, Ontario, Canada. MiCare is supported by a Canadian Institutes of Health Research (CIHR) Team Grant (CTP 87518), the Ontario Ministry of Health and Long-Term Care, and the participating hospitals. PSS holds a CIHR Applied Research Chair in Reproductive and Child Health Services and Policy Research (APR-126340). Publisher Copyright: {\textcopyright} 2021, The Author(s), under exclusive licence to Springer Nature America, Inc.",

year = "2021",

month = jun,

doi = "10.1038/s41372-021-01080-z",

language = "English",

volume = "41",

pages = "1313--1321",

journal = "Journal of Perinatology",

issn = "0743-8346",

publisher = "Nature Publishing Group",

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TY - JOUR

T1 - Neurodevelopmental outcomes of singleton large for gestational age infants <29 weeks’ gestation

T2 - a retrospective cohort study

AU - on behalf of the Canadian Neonatal Network and the Canadian Neonatal Follow-Up Program

AU - Rustogi, Deepika

AU - Synnes, Anne

AU - Alshaikh, Belal

AU - Hasan, Shabih

AU - Drolet, Christine

AU - Masse, Edith

AU - Murthy, Prashanth

AU - Shah, Prakesh S.

AU - Yusuf, Kamran

AU - Shah, Prakesh S.

AU - Beltempo, Marc

AU - Kanungo, Jaideep

AU - Ting, Joseph

AU - Mehrem, Ayman Abou

AU - Toye, Jennifer

AU - Aziz, Khalid

AU - Bodani, Jaya

AU - Strueby, Lannae

AU - Seshia, Mary

AU - Louis, Deepak

AU - Alvaro, Ruben

AU - Mukerji, Amit

AU - Da Silva, Orlando

AU - Augustine, Sajit

AU - Lee, Kyong Soon

AU - Ng, Eugene

AU - Lemyre, Brigitte

AU - Daboval, Thierry

AU - Khurshid, Faiza

AU - Bizgu, Victoria

AU - Barrington, Keith

AU - Drolet, Christine

AU - Piedboeuf, Bruno

AU - Claveau, Martine

AU - Bertelle, Valerie

AU - Masse, Edith

AU - Canning, Roderick

AU - Makary, Hala

AU - Ojah, Cecil

AU - Monterrosa, Luis

AU - Emberley, Julie

AU - Afifi, Jehier

AU - Kajetanowicz, Andrzej

AU - Lee, Shoo K.

AU - Pillay, Thevanisha

AU - Hendson, Leonora

AU - Reichert, Amber

AU - Hicks, Matthew

AU - de Cabo, Cecilia

AU - Nwaesei, Chukwuma

N1 - Funding Information: Funding Although no specific funding was received for this study, organizational support for the Canadian Neonatal Network and the Canadian Neonatal Follow-Up Network was provided by the Maternal-infant Care Research Centre (MiCare) at Mount Sinai Hospital in Toronto, Ontario, Canada. MiCare is supported by a Canadian Institutes of Health Research (CIHR) Team Grant (CTP 87518), the Ontario Ministry of Health and Long-Term Care, and the participating hospitals. PSS holds a CIHR Applied Research Chair in Reproductive and Child Health Services and Policy Research (APR-126340). Publisher Copyright: © 2021, The Author(s), under exclusive licence to Springer Nature America, Inc.

PY - 2021/6

Y1 - 2021/6

N2 - Objective: To compare neurodevelopmental outcomes of large and appropriate for gestational age (LGA, AGA) infants <29 weeks’ gestation at 18–24 months of corrected age. Study design: Retrospective cohort study using the Canadian Neonatal Network and Canadian Neonatal Follow-Up Network databases. Primary outcome was a composite of death or significant neurodevelopmental impairment (NDI), defined as severe cerebral palsy, Bayley III cognitive, language and motor scores of <70, need for hearing aids or cochlear implant and bilateral visual impairment. Univariate and multivariable logistic analyses were applied for outcomes. Results: The study cohort comprised 170 LGA and 1738 AGA infants. There was no difference in significant NDI or individual components of the Bayley III between LGA and AGA groups. LGA was associated with the increased risk of death by follow-up, 44/170 (25.9%) vs. 320/1738 (18.4%) (aOR: 1.60 95% CI: 1.00–2.54). Conclusions: Risk of NDI was similar between LGA and AGA infants.

AB - Objective: To compare neurodevelopmental outcomes of large and appropriate for gestational age (LGA, AGA) infants <29 weeks’ gestation at 18–24 months of corrected age. Study design: Retrospective cohort study using the Canadian Neonatal Network and Canadian Neonatal Follow-Up Network databases. Primary outcome was a composite of death or significant neurodevelopmental impairment (NDI), defined as severe cerebral palsy, Bayley III cognitive, language and motor scores of <70, need for hearing aids or cochlear implant and bilateral visual impairment. Univariate and multivariable logistic analyses were applied for outcomes. Results: The study cohort comprised 170 LGA and 1738 AGA infants. There was no difference in significant NDI or individual components of the Bayley III between LGA and AGA groups. LGA was associated with the increased risk of death by follow-up, 44/170 (25.9%) vs. 320/1738 (18.4%) (aOR: 1.60 95% CI: 1.00–2.54). Conclusions: Risk of NDI was similar between LGA and AGA infants.

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JO - Journal of Perinatology

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ER -

Neurodevelopmental outcomes of singleton large for gestational age infants <29 weeks’ gestation: a retrospective cohort study

Résumé

Note bibliographique

ASJC Scopus Subject Areas

PubMed: MeSH publication types

ODD de l’ONU

Accès au document

Autres fichiers et liens

Empreinte numérique

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