Neuroendocrine assessment of serotonin (5-HT) function in chronic fatigue syndrome

L. N. Yatham, R. L. Morehouse, B. T. Chisholm, D. A. Haase, D. D. MacDonald, T. J. Marrie

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41 Citations (Scopus)

Résumé

Prolactin and cortisol responses to dl-fenfluramine challenge were examined in 11 patients with chronic fatigue syndrome and in 11 healthy controls who were age and gender matched. After obtaining two baseline samples, each subject was given 60 mg of dl-fenfluramine orally and further blood samples were drawn hourly during the following five hours in order to measure prolactin and cortisol levels. There was no difference in either baseline or fenfluramine-induced hormonal responses between patients with chronic fatigue syndrome and controls. There was also no correlation between depression scores on HAM-D and hormonal responses in patients with chronic fatigue syndrome. The findings of this study do not support a role for 5-HT in chronic fatigue syndrome.

Langue d'origineEnglish
Pages (de-à)93-96
Nombre de pages4
JournalCanadian Journal of Psychiatry
Volume40
Numéro de publication2
DOI
Statut de publicationPublished - 1995
Publié à l'externeOui

ASJC Scopus Subject Areas

  • Psychiatry and Mental health

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