Nucleus reticularis lateralis involvement in the pressor component of the cerebral ischemic response

James R. Haselton; Carole L. Haselton; Pedro L. Vera; Howard H. Ellenberger; William G. LeBlanc; Neil Schneiderman; Philip M. McCabe

doi:10.1016/0006-8993(85)90484-6

Nucleus reticularis lateralis involvement in the pressor component of the cerebral ischemic response

James R. Haselton, Carole L. Haselton, Pedro L. Vera, Howard H. Ellenberger, William G. LeBlanc, Neil Schneiderman, Philip M. McCabe

Résultat de recherche: Article › examen par les pairs

7 Citations (Scopus)

Résumé

Lesions of the ventromedial portion of the nucleus reticularis lateralis (NRL) of the medulla oblongata in the rabbit significantly and markedly reduced the pressor component of the cerebral ischemic response (CIR) without altering vasomotor tone. Use of horseradish peroxidase as an anterograde and retrograde tracer indicated that the ventromedial NRL projects to the intermediolateral cell column (IML) of the upper thoracic spinal cord. Injections of glutamate into ventromedial NRL elevated blood pressure (BP), indicating that neuronal cell bodies in this area are capable of eliciting BP elevations when stimulated. These findings suggest that cell bodies in the ventromedial NRL are capable of eliciting pressor responses during the CIR via direct projections to sympathetic preganglionic cell bodies.

Langue d'origine	English
Pages (de-à)	315-320
Nombre de pages	6
Journal	Brain Research
Volume	335
Numéro de publication	2
DOI	https://doi.org/10.1016/0006-8993(85)90484-6
Statut de publication	Published - juin 3 1985
Publié à l'externe	Oui

Note bibliographique

Funding Information:
NRL is consistent with autoradiographic studies in the rat t0, cat 9 and opossum 11. The heaviest labeling of IML occurred at the T2-T4 level, which is the site of origin of the greatest number of sympathetic preganglionic cell bodies t5 with cardiomotor and vaso-motor influence TM. The present finding of retrograde labeling of cell bodies in the ventromedial NRL after application of HRP into IML agrees with previous studies in the rabbit 2,6, rat 19, cat 1,3 and opossumLl. The results of the present study as well as those of Rohlicek and Polosa 16 indicate that the pressor component of the CIR can be attenuated in the absence of a decrease in vasomotor tone. Discrepant findings reported by Dampney and Moon 5 were possibly due to their lesions either being larger than ours or not being primarily within NRL. The Rohlicek and Polo-sa 16 findings indicate that structures very close to the ventral surface of the medulla are involved in mediating phasic BP responsivity. Our results suggest a more dorsal structure, the NRL, is also capable of mediating phasic BP reactivity. Furthermore, our data indicate that neurons located in the ventromedial NRL project directly to IML and that this projection probably is involved in the pressor component of the CIR, Supported by NINCDS Grant HR542134. H.H.E. was supported by NHLBI Grant HA542738.

ASJC Scopus Subject Areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/0006-8993(85)90484-6

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@article{6edba015d41441668440dadd0af25f87,

title = "Nucleus reticularis lateralis involvement in the pressor component of the cerebral ischemic response",

abstract = "Lesions of the ventromedial portion of the nucleus reticularis lateralis (NRL) of the medulla oblongata in the rabbit significantly and markedly reduced the pressor component of the cerebral ischemic response (CIR) without altering vasomotor tone. Use of horseradish peroxidase as an anterograde and retrograde tracer indicated that the ventromedial NRL projects to the intermediolateral cell column (IML) of the upper thoracic spinal cord. Injections of glutamate into ventromedial NRL elevated blood pressure (BP), indicating that neuronal cell bodies in this area are capable of eliciting BP elevations when stimulated. These findings suggest that cell bodies in the ventromedial NRL are capable of eliciting pressor responses during the CIR via direct projections to sympathetic preganglionic cell bodies.",

author = "Haselton, {James R.} and Haselton, {Carole L.} and Vera, {Pedro L.} and Ellenberger, {Howard H.} and LeBlanc, {William G.} and Neil Schneiderman and McCabe, {Philip M.}",

note = "Funding Information: NRL is consistent with autoradiographic studies in the rat t0, cat 9 and opossum 11. The heaviest labeling of IML occurred at the T2-T4 level, which is the site of origin of the greatest number of sympathetic preganglionic cell bodies t5 with cardiomotor and vaso-motor influence TM. The present finding of retrograde labeling of cell bodies in the ventromedial NRL after application of HRP into IML agrees with previous studies in the rabbit 2,6, rat 19, cat 1,3 and opossumLl. The results of the present study as well as those of Rohlicek and Polosa 16 indicate that the pressor component of the CIR can be attenuated in the absence of a decrease in vasomotor tone. Discrepant findings reported by Dampney and Moon 5 were possibly due to their lesions either being larger than ours or not being primarily within NRL. The Rohlicek and Polo-sa 16 findings indicate that structures very close to the ventral surface of the medulla are involved in mediating phasic BP responsivity. Our results suggest a more dorsal structure, the NRL, is also capable of mediating phasic BP reactivity. Furthermore, our data indicate that neurons located in the ventromedial NRL project directly to IML and that this projection probably is involved in the pressor component of the CIR, Supported by NINCDS Grant HR542134. H.H.E. was supported by NHLBI Grant HA542738.",

year = "1985",

month = jun,

day = "3",

doi = "10.1016/0006-8993(85)90484-6",

language = "English",

volume = "335",

pages = "315--320",

journal = "Brain Research",

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T1 - Nucleus reticularis lateralis involvement in the pressor component of the cerebral ischemic response

AU - Haselton, James R.

AU - Haselton, Carole L.

AU - Vera, Pedro L.

AU - Ellenberger, Howard H.

AU - LeBlanc, William G.

AU - Schneiderman, Neil

AU - McCabe, Philip M.

N1 - Funding Information: NRL is consistent with autoradiographic studies in the rat t0, cat 9 and opossum 11. The heaviest labeling of IML occurred at the T2-T4 level, which is the site of origin of the greatest number of sympathetic preganglionic cell bodies t5 with cardiomotor and vaso-motor influence TM. The present finding of retrograde labeling of cell bodies in the ventromedial NRL after application of HRP into IML agrees with previous studies in the rabbit 2,6, rat 19, cat 1,3 and opossumLl. The results of the present study as well as those of Rohlicek and Polosa 16 indicate that the pressor component of the CIR can be attenuated in the absence of a decrease in vasomotor tone. Discrepant findings reported by Dampney and Moon 5 were possibly due to their lesions either being larger than ours or not being primarily within NRL. The Rohlicek and Polo-sa 16 findings indicate that structures very close to the ventral surface of the medulla are involved in mediating phasic BP responsivity. Our results suggest a more dorsal structure, the NRL, is also capable of mediating phasic BP reactivity. Furthermore, our data indicate that neurons located in the ventromedial NRL project directly to IML and that this projection probably is involved in the pressor component of the CIR, Supported by NINCDS Grant HR542134. H.H.E. was supported by NHLBI Grant HA542738.

PY - 1985/6/3

Y1 - 1985/6/3

N2 - Lesions of the ventromedial portion of the nucleus reticularis lateralis (NRL) of the medulla oblongata in the rabbit significantly and markedly reduced the pressor component of the cerebral ischemic response (CIR) without altering vasomotor tone. Use of horseradish peroxidase as an anterograde and retrograde tracer indicated that the ventromedial NRL projects to the intermediolateral cell column (IML) of the upper thoracic spinal cord. Injections of glutamate into ventromedial NRL elevated blood pressure (BP), indicating that neuronal cell bodies in this area are capable of eliciting BP elevations when stimulated. These findings suggest that cell bodies in the ventromedial NRL are capable of eliciting pressor responses during the CIR via direct projections to sympathetic preganglionic cell bodies.

AB - Lesions of the ventromedial portion of the nucleus reticularis lateralis (NRL) of the medulla oblongata in the rabbit significantly and markedly reduced the pressor component of the cerebral ischemic response (CIR) without altering vasomotor tone. Use of horseradish peroxidase as an anterograde and retrograde tracer indicated that the ventromedial NRL projects to the intermediolateral cell column (IML) of the upper thoracic spinal cord. Injections of glutamate into ventromedial NRL elevated blood pressure (BP), indicating that neuronal cell bodies in this area are capable of eliciting BP elevations when stimulated. These findings suggest that cell bodies in the ventromedial NRL are capable of eliciting pressor responses during the CIR via direct projections to sympathetic preganglionic cell bodies.

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Nucleus reticularis lateralis involvement in the pressor component of the cerebral ischemic response

Résumé

Note bibliographique

ASJC Scopus Subject Areas

Accès au document

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