Outcomes of MYC-associated lymphomas after R-CHOP with and without consolidative autologous stem cell transplant: subset analysis of randomized trial intergroup SWOG S9704

Soham D. Puvvada; Patrick J. Stiff; Michael Leblanc; James R. Cook; Stephen Couban; John P. Leonard; Brad Kahl; Deborah Marcellus; Thomas C. Shea; Jane N. Winter; Hongli Li; Lisa M. Rimsza; Jonathan W. Friedberg; Sonali M. Smith

doi:10.1111/bjh.14100

Outcomes of MYC-associated lymphomas after R-CHOP with and without consolidative autologous stem cell transplant: subset analysis of randomized trial intergroup SWOG S9704

Soham D. Puvvada, Patrick J. Stiff, Michael Leblanc, James R. Cook, Stephen Couban, John P. Leonard, Brad Kahl, Deborah Marcellus, Thomas C. Shea, Jane N. Winter, Hongli Li, Lisa M. Rimsza, Jonathan W. Friedberg, Sonali M. Smith

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28 Citations (Scopus)

Résumé

Double hit lymphoma (DHL) and double protein-expressing (MYC, BCL2) lymphomas (DPL) fare poorly with R-CHOP (rituximab + cyclophosphamide, doxorubicin, vincristine, prednisolone); consolidative autologous stem cell transplant (ASCT) may improve outcomes. S9704, a phase III randomized study of CHOP +/−R with or without ASCT enabled evaluation of intensive consolidation. Immunohistochemistry (IHC) identified 27 of 198 patients (13·6%) with MYC overexpression; 20 (74%) harboured concurrent BCL2 overexpression. Four had DHL and 16 had DPL only. With median 127 months follow-up, there is a trend favouring outcomes after ASCT in DPL and MYC protein overexpressing patients, whereas all DHL patients have died irrespective of ASCT.

Langue d'origine	English
Pages (de-à)	686-691
Nombre de pages	6
Journal	British Journal of Haematology
Volume	174
Numéro de publication	5
DOI	https://doi.org/10.1111/bjh.14100
Statut de publication	Published - sept. 1 2016
Publié à l'externe	Oui

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Publisher Copyright:
© 2016 John Wiley & Sons Ltd

ASJC Scopus Subject Areas

Hematology

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10.1111/bjh.14100

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Puvvada, S. D., Stiff, P. J., Leblanc, M., Cook, J. R., Couban, S., Leonard, J. P., Kahl, B., Marcellus, D., Shea, T. C., Winter, J. N., Li, H., Rimsza, L. M., Friedberg, J. W., & Smith, S. M. (2016). Outcomes of MYC-associated lymphomas after R-CHOP with and without consolidative autologous stem cell transplant: subset analysis of randomized trial intergroup SWOG S9704. British Journal of Haematology, 174(5), 686-691. https://doi.org/10.1111/bjh.14100

Outcomes of MYC-associated lymphomas after R-CHOP with and without consolidative autologous stem cell transplant: subset analysis of randomized trial intergroup SWOG S9704. / Puvvada, Soham D.; Stiff, Patrick J.; Leblanc, Michael et al.
Dans: British Journal of Haematology, Vol. 174, N° 5, 01.09.2016, p. 686-691.

Résultat de recherche: Article › examen par les pairs

Puvvada, SD, Stiff, PJ, Leblanc, M, Cook, JR, Couban, S, Leonard, JP, Kahl, B, Marcellus, D, Shea, TC, Winter, JN, Li, H, Rimsza, LM, Friedberg, JW & Smith, SM 2016, 'Outcomes of MYC-associated lymphomas after R-CHOP with and without consolidative autologous stem cell transplant: subset analysis of randomized trial intergroup SWOG S9704', British Journal of Haematology, vol. 174, n° 5, pp. 686-691. https://doi.org/10.1111/bjh.14100

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abstract = "Double hit lymphoma (DHL) and double protein-expressing (MYC, BCL2) lymphomas (DPL) fare poorly with R-CHOP (rituximab + cyclophosphamide, doxorubicin, vincristine, prednisolone); consolidative autologous stem cell transplant (ASCT) may improve outcomes. S9704, a phase III randomized study of CHOP +/−R with or without ASCT enabled evaluation of intensive consolidation. Immunohistochemistry (IHC) identified 27 of 198 patients (13·6%) with MYC overexpression; 20 (74%) harboured concurrent BCL2 overexpression. Four had DHL and 16 had DPL only. With median 127 months follow-up, there is a trend favouring outcomes after ASCT in DPL and MYC protein overexpressing patients, whereas all DHL patients have died irrespective of ASCT.",

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Outcomes of MYC-associated lymphomas after R-CHOP with and without consolidative autologous stem cell transplant: subset analysis of randomized trial intergroup SWOG S9704

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ASJC Scopus Subject Areas

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