Passive smoking increased risk of gestational diabetes mellitus independently and synergistically with prepregnancy obesity in Tianjin, China

Junhong Leng; Peng Wang; Ping Shao; Cuiping Zhang; Weiqin Li; Nan Li; Leishen Wang; Hairong Nan; Zhijie Yu; Gang Hu; Juliana C.N. Chan; Xilin Yang

doi:10.1002/dmrr.2861

Passive smoking increased risk of gestational diabetes mellitus independently and synergistically with prepregnancy obesity in Tianjin, China

Junhong Leng, Peng Wang, Ping Shao, Cuiping Zhang, Weiqin Li, Nan Li, Leishen Wang, Hairong Nan, Zhijie Yu, Gang Hu, Juliana C.N. Chan, Xilin Yang

Medicine

Résultat de recherche: Article › examen par les pairs

28 Citations (Scopus)

Résumé

Background: Passive smoking increased type 2 diabetes mellitus risk, but it is uncertain whether it also increased gestational diabetes mellitus (GDM) risk. We aimed to examine the association of passive smoking during pregnancy and its interaction with maternal obesity for GDM. Methods: From 2010 to 2012, 12 786 Chinese women underwent a 50-g 1-hour glucose challenge test at 24 to 28 weeks of gestation and further underwent a 75-g 2-hour oral glucose tolerance test if the glucose challenge test result was ≥7.8 mmol/L. GDM was defined by the International Association of Diabetes and Pregnancy Study Group's cut points. Self-reported passive smoking during pregnancy was collected by a questionnaire. Logistic regression was used to obtain odds ratios (ORs) and 95% confidence intervals (CIs). Additive interaction between maternal obesity and passive smoking was estimated using relative excess risk due to interaction (RERI), attributable proportion due to interaction (AP), and synergy index (S). Significant RERI > 0, AP > 0, or S > 1 indicated additive interaction. Results: A total of 8331 women (65.2%) were exposed to passive smoking during pregnancy. More women exposed to passive smoking developed GDM than nonexposed women (7.8% versus 6.3%, P = 0.002) with an adjusted OR of 1.29 (95%CI, 1.11 to 1.50). Compared with nonobesity and nonpassive smoking, prepregnancy obesity and passive smoking was associated with GDM risk with an adjusted OR of 3.09 (95%CI, 2.38-4.02) with significant additive interaction (P <.05 for RERI and AP). Conclusions: Passive smoking during pregnancy increased GDM risk in Chinese women independently and synergistically with prepregnancy obesity.

Langue d'origine	English
Numéro d'article	e2861
Journal	Diabetes/Metabolism Research and Reviews
Volume	33
Numéro de publication	3
DOI	https://doi.org/10.1002/dmrr.2861
Statut de publication	Published - mars 1 2017

Note bibliographique

Funding Information:
This work was supported by BRIDGES (grant number: LT09-227). BRIDGES is an International Diabetes Federation program supported by an educational grant from Lilly Diabetes. We thank all doctors, nurses, and research staffs at 65 primary care hospitals, 6 district-level women and children's health centers (WCHCs), and the Tianjin Women and Children's Health Center (TWCHC) for their participation in this study. X.Y., J.C., G.H., Z.Y., and H.N. conceived and designed the study; all authors, except H.N., Z.Y., G.H., J.C., and X.Y., contributed to the collection of the data. J.L. analyzed the data and wrote the first draft; all authors gave critical comments and contributed to the writing of the manuscript; X.Y. (the corresponding authors) and J.L. (the first author) take full responsibility for the work as a whole, including the study design, access to data, and the decision to submit and publish the manuscript.

Publisher Copyright:
Copyright © 2016 John Wiley & Sons, Ltd.

ASJC Scopus Subject Areas

Internal Medicine
Endocrinology, Diabetes and Metabolism
Endocrinology

PubMed: MeSH publication types

Journal Article
Research Support, Non-U.S. Gov't

ODD de l’ONU

Cette action contribue à la réalisation des objectifs de développement durable suivants

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10.1002/dmrr.2861

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title = "Passive smoking increased risk of gestational diabetes mellitus independently and synergistically with prepregnancy obesity in Tianjin, China",

abstract = "Background: Passive smoking increased type 2 diabetes mellitus risk, but it is uncertain whether it also increased gestational diabetes mellitus (GDM) risk. We aimed to examine the association of passive smoking during pregnancy and its interaction with maternal obesity for GDM. Methods: From 2010 to 2012, 12 786 Chinese women underwent a 50-g 1-hour glucose challenge test at 24 to 28 weeks of gestation and further underwent a 75-g 2-hour oral glucose tolerance test if the glucose challenge test result was ≥7.8 mmol/L. GDM was defined by the International Association of Diabetes and Pregnancy Study Group's cut points. Self-reported passive smoking during pregnancy was collected by a questionnaire. Logistic regression was used to obtain odds ratios (ORs) and 95% confidence intervals (CIs). Additive interaction between maternal obesity and passive smoking was estimated using relative excess risk due to interaction (RERI), attributable proportion due to interaction (AP), and synergy index (S). Significant RERI > 0, AP > 0, or S > 1 indicated additive interaction. Results: A total of 8331 women (65.2%) were exposed to passive smoking during pregnancy. More women exposed to passive smoking developed GDM than nonexposed women (7.8% versus 6.3%, P = 0.002) with an adjusted OR of 1.29 (95%CI, 1.11 to 1.50). Compared with nonobesity and nonpassive smoking, prepregnancy obesity and passive smoking was associated with GDM risk with an adjusted OR of 3.09 (95%CI, 2.38-4.02) with significant additive interaction (P <.05 for RERI and AP). Conclusions: Passive smoking during pregnancy increased GDM risk in Chinese women independently and synergistically with prepregnancy obesity.",

author = "Junhong Leng and Peng Wang and Ping Shao and Cuiping Zhang and Weiqin Li and Nan Li and Leishen Wang and Hairong Nan and Zhijie Yu and Gang Hu and Chan, {Juliana C.N.} and Xilin Yang",

note = "Funding Information: This work was supported by BRIDGES (grant number: LT09-227). BRIDGES is an International Diabetes Federation program supported by an educational grant from Lilly Diabetes. We thank all doctors, nurses, and research staffs at 65 primary care hospitals, 6 district-level women and children's health centers (WCHCs), and the Tianjin Women and Children's Health Center (TWCHC) for their participation in this study. X.Y., J.C., G.H., Z.Y., and H.N. conceived and designed the study; all authors, except H.N., Z.Y., G.H., J.C., and X.Y., contributed to the collection of the data. J.L. analyzed the data and wrote the first draft; all authors gave critical comments and contributed to the writing of the manuscript; X.Y. (the corresponding authors) and J.L. (the first author) take full responsibility for the work as a whole, including the study design, access to data, and the decision to submit and publish the manuscript. Publisher Copyright: Copyright {\textcopyright} 2016 John Wiley & Sons, Ltd.",

year = "2017",

month = mar,

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doi = "10.1002/dmrr.2861",

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volume = "33",

journal = "Diabetes/Metabolism Research and Reviews",

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T1 - Passive smoking increased risk of gestational diabetes mellitus independently and synergistically with prepregnancy obesity in Tianjin, China

AU - Leng, Junhong

AU - Wang, Peng

AU - Shao, Ping

AU - Zhang, Cuiping

AU - Li, Weiqin

AU - Li, Nan

AU - Wang, Leishen

AU - Nan, Hairong

AU - Yu, Zhijie

AU - Hu, Gang

AU - Chan, Juliana C.N.

AU - Yang, Xilin

N1 - Funding Information: This work was supported by BRIDGES (grant number: LT09-227). BRIDGES is an International Diabetes Federation program supported by an educational grant from Lilly Diabetes. We thank all doctors, nurses, and research staffs at 65 primary care hospitals, 6 district-level women and children's health centers (WCHCs), and the Tianjin Women and Children's Health Center (TWCHC) for their participation in this study. X.Y., J.C., G.H., Z.Y., and H.N. conceived and designed the study; all authors, except H.N., Z.Y., G.H., J.C., and X.Y., contributed to the collection of the data. J.L. analyzed the data and wrote the first draft; all authors gave critical comments and contributed to the writing of the manuscript; X.Y. (the corresponding authors) and J.L. (the first author) take full responsibility for the work as a whole, including the study design, access to data, and the decision to submit and publish the manuscript. Publisher Copyright: Copyright © 2016 John Wiley & Sons, Ltd.

PY - 2017/3/1

Y1 - 2017/3/1

N2 - Background: Passive smoking increased type 2 diabetes mellitus risk, but it is uncertain whether it also increased gestational diabetes mellitus (GDM) risk. We aimed to examine the association of passive smoking during pregnancy and its interaction with maternal obesity for GDM. Methods: From 2010 to 2012, 12 786 Chinese women underwent a 50-g 1-hour glucose challenge test at 24 to 28 weeks of gestation and further underwent a 75-g 2-hour oral glucose tolerance test if the glucose challenge test result was ≥7.8 mmol/L. GDM was defined by the International Association of Diabetes and Pregnancy Study Group's cut points. Self-reported passive smoking during pregnancy was collected by a questionnaire. Logistic regression was used to obtain odds ratios (ORs) and 95% confidence intervals (CIs). Additive interaction between maternal obesity and passive smoking was estimated using relative excess risk due to interaction (RERI), attributable proportion due to interaction (AP), and synergy index (S). Significant RERI > 0, AP > 0, or S > 1 indicated additive interaction. Results: A total of 8331 women (65.2%) were exposed to passive smoking during pregnancy. More women exposed to passive smoking developed GDM than nonexposed women (7.8% versus 6.3%, P = 0.002) with an adjusted OR of 1.29 (95%CI, 1.11 to 1.50). Compared with nonobesity and nonpassive smoking, prepregnancy obesity and passive smoking was associated with GDM risk with an adjusted OR of 3.09 (95%CI, 2.38-4.02) with significant additive interaction (P <.05 for RERI and AP). Conclusions: Passive smoking during pregnancy increased GDM risk in Chinese women independently and synergistically with prepregnancy obesity.

AB - Background: Passive smoking increased type 2 diabetes mellitus risk, but it is uncertain whether it also increased gestational diabetes mellitus (GDM) risk. We aimed to examine the association of passive smoking during pregnancy and its interaction with maternal obesity for GDM. Methods: From 2010 to 2012, 12 786 Chinese women underwent a 50-g 1-hour glucose challenge test at 24 to 28 weeks of gestation and further underwent a 75-g 2-hour oral glucose tolerance test if the glucose challenge test result was ≥7.8 mmol/L. GDM was defined by the International Association of Diabetes and Pregnancy Study Group's cut points. Self-reported passive smoking during pregnancy was collected by a questionnaire. Logistic regression was used to obtain odds ratios (ORs) and 95% confidence intervals (CIs). Additive interaction between maternal obesity and passive smoking was estimated using relative excess risk due to interaction (RERI), attributable proportion due to interaction (AP), and synergy index (S). Significant RERI > 0, AP > 0, or S > 1 indicated additive interaction. Results: A total of 8331 women (65.2%) were exposed to passive smoking during pregnancy. More women exposed to passive smoking developed GDM than nonexposed women (7.8% versus 6.3%, P = 0.002) with an adjusted OR of 1.29 (95%CI, 1.11 to 1.50). Compared with nonobesity and nonpassive smoking, prepregnancy obesity and passive smoking was associated with GDM risk with an adjusted OR of 3.09 (95%CI, 2.38-4.02) with significant additive interaction (P <.05 for RERI and AP). Conclusions: Passive smoking during pregnancy increased GDM risk in Chinese women independently and synergistically with prepregnancy obesity.

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Passive smoking increased risk of gestational diabetes mellitus independently and synergistically with prepregnancy obesity in Tianjin, China

Résumé

Note bibliographique

ASJC Scopus Subject Areas

PubMed: MeSH publication types

ODD de l’ONU

Accès au document

Autres fichiers et liens

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