Perflutren lipid microsphere injectable suspension for cardiac ultrasound

Echocardiography is a widely available noninvasive procedure for diagnosing cardiovascular disease. With the development of clinically useful microbubble contrast agents to enhance echocardiographic images and advantages of portability without radiation, microbubble contrast agents have become essential established adjunctive tools to perform state-of-the-art echocardiography. Several manufacturers produce commercially available stabilized microbubbles for intravenous use. Perflutren lipid microsphere (DEFINITY®) is one of the second generation microbubble contrast agents approved for left ventricular opacification and left ventricular endocardial border detection, and is the subject of this review.