Phospholipid Synthesis in Mammalian Cells

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Résumé

Phospholipids are composed of a hydrophobic diacylglycerol (DAG) moiety attached to a hydrophilic phospho- head group. Amphipathic phospholipids are components of membranes, secreted in protein-lipid complexes and precursors for signalling factors. Phospholipid biosynthesis occurs primarily in the endoplasmic reticulum or where the endoplasmic reticulum contacts other organelles for efficient coupling of synthesis and transport. De novo phospholipid biosynthesis utilises DAG or CDP-DAG to which are added choline, ethanolamine, inositol and glycerol to form phosphatidylcholine, phosphatidylethanolamine, phosphatidylinositol and cardiolipin, respectively. The phospholipid head groups are further modified by serine base change, methylation and phosphorylation. Similarly, phospholipid fatty acids are remodelled by exchange reactions. This combination of biosynthetic and remodelling pathways generates diverse phospholipid species that are essential for cellular function.

Langue d'origineEnglish
Titre de la publication principaleBiochemistry of Lipids, Lipoproteins and Membranes
Sous-titre de la publication principaleSixth Edition
Maison d'éditionElsevier Inc.
Pages209-236
Nombre de pages28
ISBN (imprimé)9780444634382
DOI
Statut de publicationPublished - 2016

Note bibliographique

Publisher Copyright:
© 2016 Elsevier B.V. All rights reserved.

ASJC Scopus Subject Areas

  • General Biochemistry,Genetics and Molecular Biology

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