Physical pain recruits the nucleus accumbens during social distress in borderline personality disorder

Emilie Olié, Kimberly C. Doell, Corrado Corradi-Dell'Acqua, Philippe Courtet, Nader Perroud, Sophie Schwartz

Résultat de recherche: Articleexamen par les pairs

21 Citations (Scopus)

Résumé

Patients with borderline personality disorder (BPD) often engage in dangerous self-injurious behaviors (SIBs) as a maladaptive technique to decrease heightened feelings of distress (e.g. negative feelings caused by social exclusion). The reward system has recently been proposed as a plausible neural substrate, which may influence the interaction between social distress and physical pain processing in patients that engage in SIBs. Using functional magnetic resonance imaging (fMRI) in 20 adult BPD patients with a history of SIBs and 23 healthy controls (HCs), we found a hyper-activation of the nucleus accumbens (NAcc) and amygdala when painful stimuli were presented to BPD patients (but not HCs) in a state of heightened distress, induced via social exclusion. This differential NAcc activity was mediated by anxious attachment style, which is a key developmental feature of the disorder. Altogether, these results suggest a neural mechanism underlying the pathophysiology of SIBs in these patients, which is likely reinforced via the reward system.

Langue d'origineEnglish
Pages (de-à)1071-1080
Nombre de pages10
JournalSocial Cognitive and Affective Neuroscience
Volume13
Numéro de publication10
DOI
Statut de publicationPublished - oct. 25 2018
Publié à l'externeOui

Note bibliographique

Funding Information:
This work was supported by the National Center of Competence in Research (NCCR) Affective Sciences financed by the Swiss National Science Foundation (grant number 51NF40-104897) and hosted by the University of Geneva, and by the grant SFETD-IUD 2012 from Institut UPSA de la Douleur (to E.O.).

Funding Information:
We would like to thank Rosetta Nicastro and Paco Prada for their role in recruiting the BPD patients as well as Emilie Douine for her help in assessing all participants. Lastly, thank you to Amanda Buckley (amanda@notinsidethebox. com) for her consultation with the figures in thismanuscript. This work was supported by the National Center of Competence in Research (NCCR) Affective Sciences financed by the Swiss National Science Foundation (grant number 51NF40-104897) and hosted by the University of Geneva, and by the grant SFETD-IUD 2012 from Institut UPSA de la Douleur (to E.O.).

Publisher Copyright:
© The Author(s) 2018.

ASJC Scopus Subject Areas

  • Experimental and Cognitive Psychology
  • Cognitive Neuroscience

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