Physiological and Neurobehavioral Consequences of Chronic Sleep Restriction in Rodent Models

Chronically insufficient sleep is common in our society and negatively impacts cognitive performance and health. Although there is a belief that one can adapt to chronic sleep restriction (CSR), there is evidence for negative consequences, including impaired cognitive performance, and increased risks for cardiovascular and metabolic diseases. This review briefly surveys the research using rodent models to evaluate the consequences of CSR on functions and systems ranging from sleep, cognitive performance, stress neuroendocrinology, metabolism, peripheral organs, and the brain. Many of these consequences are significant, and some are long-lasting. Future research is required to understand the dynamics of these various impacts over time and relative to each other and to identify biomarkers for the mechanisms that support adaptive responses to CSR. This information will help in developing strategies to reduce the impact of chronic sleep loss.