Résumé
The need for new cancer chemoprevention approaches is evident by the continued increase of the social and economic burden due to cancer incidence worldwide. Polyphenols, ubiquitous dietary antioxidants present in plant foods, possess chemopreventive and therapeutic characteristics. However, the chemoprevention potential of oligomeric and polymeric polyphenols is considerably limited due to their low bioavailability, characterized by limited absorption. Colonic microbiota plays an important role in the absorption of these complexly structured polyphenols, by converting them into easily absorbable and simple phenolic compounds. Therefore, the chemopreventive potential of complex polyphenols is greatly dependent on the colonic microbiota of individuals. This review reveals that a synbiotic intervention could be more useful in such cases to alleviate prebiotic and probiotic interdependency and improve the potential in chemoprevention. The chemopreventive potential of many microbial metabolites of polyphenols is well established by in vitro studies. Further investigations are required in this area to evaluate in vivo efficacy of these metabolites in chemoprevention.
| Langue d'origine | English |
|---|---|
| Pages (de-à) | 51-57 |
| Nombre de pages | 7 |
| Journal | Current Opinion in Food Science |
| Volume | 20 |
| DOI | |
| Statut de publication | Published - avr. 2018 |
Note bibliographique
Funding Information:We would like to thank for the traineeship award (W Thilakarathna) received from the Beatrice Hunter Cancer Research Institute with funds provided by the Saunders-Matthey award for cancer prevention research as part of the Terry Fox strategic health research training program in cancer research at Canadian Institute of Health Research (CIHR).
Publisher Copyright:
© 2018 Elsevier Ltd
ASJC Scopus Subject Areas
- Food Science
- Applied Microbiology and Biotechnology
ODD de l’ONU
Cette action contribue à la réalisation des objectifs de développement durable suivants
