Porous calcium polyphosphate scaffolds for bone substitute applications - In vitro characterization

Porous structures were formed by gravity sintering calcium polyphosphate (CPP) particles of either 106-150 or 150-250μm size to form samples with 30-45vol% porosity with pore sizes in the range of 100μm (40-140μm). Tensile strength of the samples assessed by diametral compression testing indicated relatively high values for porous ceramics with a maximum strength of 24.1MPa for samples made using the finer particles (106-150μm). X-ray diffraction studies of the sintered samples indicated the formation of β-CPP from the starting amorphous powders. In vitro aging in 0.1M tris-buffered solution (pH 7.4) or 0.05M potassium hydrogen phthalate buffered solution (pH 4.0) at 37°C for periods up to 30d indicated an initial rapid loss of strength and P elution by 1d followed by a more gradual continuing strength and P loss resulting in strengths at 30d equal to about one-third the initial value. The observed structures, strengths and in vitro degradation characteristics of the porous CPP samples suggested their potential usefulness as bone substitute materials pending subsequent in vivo behaviour assessment.