Probiotics for preterm infants: A National Retrospective Cohort Study

on behalf of the Canadian Neonatal Network Investigators

doi:10.1038/s41372-019-0315-z

Probiotics for preterm infants: A National Retrospective Cohort Study

on behalf of the Canadian Neonatal Network Investigators

Medicine

Résultat de recherche: Article › examen par les pairs

30 Citations (Scopus)

Résumé

Objective: To evaluate the effect of prophylactic probiotic (PP) administration on rates of necrotizing enterocolitis (NEC), late-onset sepsis (LOS), and mortality in preterm infants. Study design: We conducted a retrospective cohort study of infants < 29 weeks’ gestation, admitted to neonatal intensive care units participating in the Canadian Neonatal Network between 1 January 2014 and 31 December 2015. Infants in the exposure group received PP. A multiple logistic regression model with generalized estimation equation was used. Results: A total of 3093 infants were included, 652 infants (21%) received PP. The adjusted odds ratios (aOR) of NEC (aOR 0.64, 95% confidence interval [CI] 0.410, 0.996), mortality (aOR 0.41, 95% CI 0.26, 0.63), and a composite of NEC or mortality were significantly lower in the PP group. There was no significant difference in the aOR of LOS. Conclusion: Prophylactic probiotic administration is associated with a reduction in NEC and mortality in preterm infants.

Langue d'origine	English
Pages (de-à)	533-539
Nombre de pages	7
Journal	Journal of Perinatology
Volume	39
Numéro de publication	4
DOI	https://doi.org/10.1038/s41372-019-0315-z
Statut de publication	Published - avr. 1 2019

Note bibliographique

Funding Information:
Acknowledgements We gratefully acknowledge all site investigators and abstractors of the Canadian Neonatal Network (CNN). We also thank the staff at the Maternal-Infant Care (MICare) Research Center at Mount Sinai Hospital, Toronto, ON for organizational support of CNN. In addition, we thank Xiang Y Ye, MSc for statistical support and Sarah Hutchinson, Ph.D for editorial assistance in the preparation of this manuscript. MICare is supported by a team grant from the Canadian Institutes of Health Research (CTP 87518), the Ontario Ministry of Health, and in-kind support from Mount Sinai Hospital.

Publisher Copyright:
© 2019, Springer Nature America, Inc.

ASJC Scopus Subject Areas

Pediatrics, Perinatology, and Child Health
Obstetrics and Gynaecology

PubMed: MeSH publication types

Journal Article
Research Support, Non-U.S. Gov't

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10.1038/s41372-019-0315-z

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title = "Probiotics for preterm infants: A National Retrospective Cohort Study",

abstract = "Objective: To evaluate the effect of prophylactic probiotic (PP) administration on rates of necrotizing enterocolitis (NEC), late-onset sepsis (LOS), and mortality in preterm infants. Study design: We conducted a retrospective cohort study of infants < 29 weeks{\textquoteright} gestation, admitted to neonatal intensive care units participating in the Canadian Neonatal Network between 1 January 2014 and 31 December 2015. Infants in the exposure group received PP. A multiple logistic regression model with generalized estimation equation was used. Results: A total of 3093 infants were included, 652 infants (21%) received PP. The adjusted odds ratios (aOR) of NEC (aOR 0.64, 95% confidence interval [CI] 0.410, 0.996), mortality (aOR 0.41, 95% CI 0.26, 0.63), and a composite of NEC or mortality were significantly lower in the PP group. There was no significant difference in the aOR of LOS. Conclusion: Prophylactic probiotic administration is associated with a reduction in NEC and mortality in preterm infants.",

author = "{on behalf of the Canadian Neonatal Network Investigators} and Balpreet Singh and Shah, {Prakesh S.} and Jehier Afifi and Simpson, {C. David} and Souvik Mitra and Kimberly Dow and Walid El-Naggar",

note = "Funding Information: Acknowledgements We gratefully acknowledge all site investigators and abstractors of the Canadian Neonatal Network (CNN). We also thank the staff at the Maternal-Infant Care (MICare) Research Center at Mount Sinai Hospital, Toronto, ON for organizational support of CNN. In addition, we thank Xiang Y Ye, MSc for statistical support and Sarah Hutchinson, Ph.D for editorial assistance in the preparation of this manuscript. MICare is supported by a team grant from the Canadian Institutes of Health Research (CTP 87518), the Ontario Ministry of Health, and in-kind support from Mount Sinai Hospital. Publisher Copyright: {\textcopyright} 2019, Springer Nature America, Inc.",

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AU - Singh, Balpreet

AU - Shah, Prakesh S.

AU - Afifi, Jehier

AU - Simpson, C. David

AU - Mitra, Souvik

AU - Dow, Kimberly

AU - El-Naggar, Walid

N1 - Funding Information: Acknowledgements We gratefully acknowledge all site investigators and abstractors of the Canadian Neonatal Network (CNN). We also thank the staff at the Maternal-Infant Care (MICare) Research Center at Mount Sinai Hospital, Toronto, ON for organizational support of CNN. In addition, we thank Xiang Y Ye, MSc for statistical support and Sarah Hutchinson, Ph.D for editorial assistance in the preparation of this manuscript. MICare is supported by a team grant from the Canadian Institutes of Health Research (CTP 87518), the Ontario Ministry of Health, and in-kind support from Mount Sinai Hospital. Publisher Copyright: © 2019, Springer Nature America, Inc.

PY - 2019/4/1

Y1 - 2019/4/1

N2 - Objective: To evaluate the effect of prophylactic probiotic (PP) administration on rates of necrotizing enterocolitis (NEC), late-onset sepsis (LOS), and mortality in preterm infants. Study design: We conducted a retrospective cohort study of infants < 29 weeks’ gestation, admitted to neonatal intensive care units participating in the Canadian Neonatal Network between 1 January 2014 and 31 December 2015. Infants in the exposure group received PP. A multiple logistic regression model with generalized estimation equation was used. Results: A total of 3093 infants were included, 652 infants (21%) received PP. The adjusted odds ratios (aOR) of NEC (aOR 0.64, 95% confidence interval [CI] 0.410, 0.996), mortality (aOR 0.41, 95% CI 0.26, 0.63), and a composite of NEC or mortality were significantly lower in the PP group. There was no significant difference in the aOR of LOS. Conclusion: Prophylactic probiotic administration is associated with a reduction in NEC and mortality in preterm infants.

AB - Objective: To evaluate the effect of prophylactic probiotic (PP) administration on rates of necrotizing enterocolitis (NEC), late-onset sepsis (LOS), and mortality in preterm infants. Study design: We conducted a retrospective cohort study of infants < 29 weeks’ gestation, admitted to neonatal intensive care units participating in the Canadian Neonatal Network between 1 January 2014 and 31 December 2015. Infants in the exposure group received PP. A multiple logistic regression model with generalized estimation equation was used. Results: A total of 3093 infants were included, 652 infants (21%) received PP. The adjusted odds ratios (aOR) of NEC (aOR 0.64, 95% confidence interval [CI] 0.410, 0.996), mortality (aOR 0.41, 95% CI 0.26, 0.63), and a composite of NEC or mortality were significantly lower in the PP group. There was no significant difference in the aOR of LOS. Conclusion: Prophylactic probiotic administration is associated with a reduction in NEC and mortality in preterm infants.

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Probiotics for preterm infants: A National Retrospective Cohort Study

Résumé

Note bibliographique

ASJC Scopus Subject Areas

PubMed: MeSH publication types

Accès au document

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