Proliferative Versus Degenerative Paradigms in Pulmonary Arterial Hypertension: Have We Put the Cart before the Horse?

Ketul R. Chaudhary, Mohamad Taha, Virgilio J.J. Cadete, Rafael S. Godoy, Duncan J. Stewart

Résultat de recherche: Review articleexamen par les pairs

30 Citations (Scopus)

Résumé

Pulmonary arterial hypertension is believed to be a proliferative disease, triggered by endothelial cell injury and apoptosis and leading to the formation of occlusive vascular lesions caused by growth-dysregulated "cancerlike" cells. However, the current experimental and clinical evidence is not entirely consistent with this paradigm and suggests an alternate interpretation, specifically that microvascular rarefaction may be due to a degenerative process, driven by sustained endothelial cell apoptosis. The "degenerative" paradigm has important implications, not the least of which is that proliferative lesions may be a secondary manifestation of disease rather than the primary cause of microvascular rarefaction, and that regenerative strategies may be needed to restore the microcirculation in established disease.

Langue d'origineEnglish
Pages (de-à)1237-1239
Nombre de pages3
JournalCirculation Research
Volume120
Numéro de publication8
DOI
Statut de publicationPublished - avr. 14 2017
Publié à l'externeOui

Note bibliographique

Publisher Copyright:
© 2017 American Heart Association, Inc.

ASJC Scopus Subject Areas

  • Physiology
  • Cardiology and Cardiovascular Medicine

PubMed: MeSH publication types

  • Journal Article
  • Research Support, Non-U.S. Gov't
  • Review

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