Résumé
Pulmonary arterial hypertension is believed to be a proliferative disease, triggered by endothelial cell injury and apoptosis and leading to the formation of occlusive vascular lesions caused by growth-dysregulated "cancerlike" cells. However, the current experimental and clinical evidence is not entirely consistent with this paradigm and suggests an alternate interpretation, specifically that microvascular rarefaction may be due to a degenerative process, driven by sustained endothelial cell apoptosis. The "degenerative" paradigm has important implications, not the least of which is that proliferative lesions may be a secondary manifestation of disease rather than the primary cause of microvascular rarefaction, and that regenerative strategies may be needed to restore the microcirculation in established disease.
Langue d'origine | English |
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Pages (de-à) | 1237-1239 |
Nombre de pages | 3 |
Journal | Circulation Research |
Volume | 120 |
Numéro de publication | 8 |
DOI | |
Statut de publication | Published - avr. 14 2017 |
Publié à l'externe | Oui |
Note bibliographique
Publisher Copyright:© 2017 American Heart Association, Inc.
ASJC Scopus Subject Areas
- Physiology
- Cardiology and Cardiovascular Medicine
PubMed: MeSH publication types
- Journal Article
- Research Support, Non-U.S. Gov't
- Review