Protective effect of schisanhenol against oxygen radical induced mitochondrial toxicity on rat heart and liver.

T. Lin, G. Liu, Y. Pan

Résultat de recherche: Articleexamen par les pairs

8 Citations (Scopus)

Résumé

Schisanhenol (SAL) had been shown to have potent antioxidant activities. The protective effects of SAL against oxygen radical induced mitochondrial injuries of rat heart and liver were investigated in the present study. The ferrous-cysteine induced mitochondrial lipid peroxidation was significantly inhibited by SAL, while the loss of ATPase activity induced by the lipid peroxidation was prevented. The rigidification of mitochondrial membrane, as well as swelling, lysis and disintegration of the mitochondria induced by ferrous-cysteine were all significantly inhibited by SAL. These results further confirm that SAL possesses antioxidant activity.

Langue d'origineEnglish
Pages (de-à)57-64
Nombre de pages8
JournalBiomedical and Environmental Sciences
Volume5
Numéro de publication1
Statut de publicationPublished - mars 1992
Publié à l'externeOui

ASJC Scopus Subject Areas

  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

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