Reduction of the rewarding effect of brain stimulation by a blockade of dopamine D1 receptor with SCH 23390

Shinshu Nakajima; Gerald M. McKenzie

doi:10.1016/0091-3057(86)90437-5

Reduction of the rewarding effect of brain stimulation by a blockade of dopamine D1 receptor with SCH 23390

Shinshu Nakajima, Gerald M. McKenzie

Medicine

Medicine

Résultat de recherche: Article › examen par les pairs

75 Citations (Scopus)

Résumé

The subtype of dopamine receptor related to the rewarding effect of brain stimulation was determined in 17 rats. The animals were trained to contact a dry spout to receive stimulation through electrodes implanted into the lateral hypothalamic area, ventral tegmental area, or dorsal raphe nucleus. The dopamine D1 blocking agent SCH 23390, 0.08 mg/kg IP, completely suppressed responding. The D2 receptor blocker sulpiride, 50 mg/kg IP, or the serotonin receptor blocker metergoline, 5 mg/kg IP, did not suppress responding. The ED50 for SCH 23390 was 0.022 mg/kg IP. In a runway, rats were trained to run for rewarding goal stimulation consisting of a train of pulses delivered to the lateral hypothalamus. After injection of SCH 23390, 0.01 mg/kg IP, animals showed significantly slower running speed, but their speed returned to normal if the number of pulses in the goal stimulation was increased 2.6 times. These results indicate that blockade of D1 receptors, but not D2 receptors, reduces the rewarding effect of brain stimulation.

Langue d'origine	English
Pages (de-à)	919-923
Nombre de pages	5
Journal	Pharmacology, Biochemistry and Behavior
Volume	24
Numéro de publication	4
DOI	https://doi.org/10.1016/0091-3057(86)90437-5
Statut de publication	Published - avr. 1986

Note bibliographique

Funding Information:
SCH 23390, on the other hand, has a very high aff'mity for the dopamlne DI receptor (Ki= 1.3-11 nM) compared to its affimty for D2 receptor (Ki=880 nM) \[1, 4, 14\] At doses between 0 11 and 2.1 mg/kg in the rat, SCH 23390 suppressed stereotypic behaviour produced by apomorphtne \[4,15\], showing a dopamine antagomst action It had no effect on serum prolactm levels \[15\],w hich ~s considered to be under D2-receptor control \[6\]. Therefore, SCH 23390 is highly hkely to have a competitive antagomst action at the DI receptor sites but not at the D2 sites. In the present study, SCH 23390 and suiptride were used to identify the receptor subtype of dopaminergic neurons revolved in intracranial mTMs research was supported by the Natural Soences and Engineenng Research Councd of Canada, Grant A0233 2Requests for repnnts should be addressed to S Nakaj~ma, Department of Psychology, Dalhousm Umverstty, Halifax. Nova Scotia, Canada

ASJC Scopus Subject Areas

Biochemistry
Toxicology
Pharmacology
Clinical Biochemistry
Biological Psychiatry
Behavioral Neuroscience

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10.1016/0091-3057(86)90437-5

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title = "Reduction of the rewarding effect of brain stimulation by a blockade of dopamine D1 receptor with SCH 23390",

abstract = "The subtype of dopamine receptor related to the rewarding effect of brain stimulation was determined in 17 rats. The animals were trained to contact a dry spout to receive stimulation through electrodes implanted into the lateral hypothalamic area, ventral tegmental area, or dorsal raphe nucleus. The dopamine D1 blocking agent SCH 23390, 0.08 mg/kg IP, completely suppressed responding. The D2 receptor blocker sulpiride, 50 mg/kg IP, or the serotonin receptor blocker metergoline, 5 mg/kg IP, did not suppress responding. The ED50 for SCH 23390 was 0.022 mg/kg IP. In a runway, rats were trained to run for rewarding goal stimulation consisting of a train of pulses delivered to the lateral hypothalamus. After injection of SCH 23390, 0.01 mg/kg IP, animals showed significantly slower running speed, but their speed returned to normal if the number of pulses in the goal stimulation was increased 2.6 times. These results indicate that blockade of D1 receptors, but not D2 receptors, reduces the rewarding effect of brain stimulation.",

author = "Shinshu Nakajima and McKenzie, {Gerald M.}",

note = "Funding Information: SCH 23390, on the other hand, has a very high aff'mity for the dopamlne DI receptor (Ki= 1.3-11 nM) compared to its affimty for D2 receptor (Ki=880 nM) \[1, 4, 14\] At doses between 0 11 and 2.1 mg/kg in the rat, SCH 23390 suppressed stereotypic behaviour produced by apomorphtne \[4,15\], showing a dopamine antagomst action It had no effect on serum prolactm levels \[15\],w hich ~s considered to be under D2-receptor control \[6\]. Therefore, SCH 23390 is highly hkely to have a competitive antagomst action at the DI receptor sites but not at the D2 sites. In the present study, SCH 23390 and suiptride were used to identify the receptor subtype of dopaminergic neurons revolved in intracranial mTMs research was supported by the Natural Soences and Engineenng Research Councd of Canada, Grant A0233 2Requests for repnnts should be addressed to S Nakaj~ma, Department of Psychology, Dalhousm Umverstty, Halifax. Nova Scotia, Canada",

year = "1986",

month = apr,

doi = "10.1016/0091-3057(86)90437-5",

language = "English",

volume = "24",

pages = "919--923",

journal = "Pharmacology, Biochemistry and Behavior",

issn = "0091-3057",

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T1 - Reduction of the rewarding effect of brain stimulation by a blockade of dopamine D1 receptor with SCH 23390

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AU - McKenzie, Gerald M.

N1 - Funding Information: SCH 23390, on the other hand, has a very high aff'mity for the dopamlne DI receptor (Ki= 1.3-11 nM) compared to its affimty for D2 receptor (Ki=880 nM) \[1, 4, 14\] At doses between 0 11 and 2.1 mg/kg in the rat, SCH 23390 suppressed stereotypic behaviour produced by apomorphtne \[4,15\], showing a dopamine antagomst action It had no effect on serum prolactm levels \[15\],w hich ~s considered to be under D2-receptor control \[6\]. Therefore, SCH 23390 is highly hkely to have a competitive antagomst action at the DI receptor sites but not at the D2 sites. In the present study, SCH 23390 and suiptride were used to identify the receptor subtype of dopaminergic neurons revolved in intracranial mTMs research was supported by the Natural Soences and Engineenng Research Councd of Canada, Grant A0233 2Requests for repnnts should be addressed to S Nakaj~ma, Department of Psychology, Dalhousm Umverstty, Halifax. Nova Scotia, Canada

PY - 1986/4

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N2 - The subtype of dopamine receptor related to the rewarding effect of brain stimulation was determined in 17 rats. The animals were trained to contact a dry spout to receive stimulation through electrodes implanted into the lateral hypothalamic area, ventral tegmental area, or dorsal raphe nucleus. The dopamine D1 blocking agent SCH 23390, 0.08 mg/kg IP, completely suppressed responding. The D2 receptor blocker sulpiride, 50 mg/kg IP, or the serotonin receptor blocker metergoline, 5 mg/kg IP, did not suppress responding. The ED50 for SCH 23390 was 0.022 mg/kg IP. In a runway, rats were trained to run for rewarding goal stimulation consisting of a train of pulses delivered to the lateral hypothalamus. After injection of SCH 23390, 0.01 mg/kg IP, animals showed significantly slower running speed, but their speed returned to normal if the number of pulses in the goal stimulation was increased 2.6 times. These results indicate that blockade of D1 receptors, but not D2 receptors, reduces the rewarding effect of brain stimulation.

AB - The subtype of dopamine receptor related to the rewarding effect of brain stimulation was determined in 17 rats. The animals were trained to contact a dry spout to receive stimulation through electrodes implanted into the lateral hypothalamic area, ventral tegmental area, or dorsal raphe nucleus. The dopamine D1 blocking agent SCH 23390, 0.08 mg/kg IP, completely suppressed responding. The D2 receptor blocker sulpiride, 50 mg/kg IP, or the serotonin receptor blocker metergoline, 5 mg/kg IP, did not suppress responding. The ED50 for SCH 23390 was 0.022 mg/kg IP. In a runway, rats were trained to run for rewarding goal stimulation consisting of a train of pulses delivered to the lateral hypothalamus. After injection of SCH 23390, 0.01 mg/kg IP, animals showed significantly slower running speed, but their speed returned to normal if the number of pulses in the goal stimulation was increased 2.6 times. These results indicate that blockade of D1 receptors, but not D2 receptors, reduces the rewarding effect of brain stimulation.

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Reduction of the rewarding effect of brain stimulation by a blockade of dopamine D1 receptor with SCH 23390

Résumé

Note bibliographique

ASJC Scopus Subject Areas

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