Regionální vychytávání glukózy (¹⁸FDG-PET) u pacientů s 1. Epizodou schizofrenie

Some studies detected abnormalities in rest brain glucose uptake in patients with schizophrenia. These results could be done due to antipsychotic therapy or due to schizophrenia. Methods: We assessed the group of patients with the 1^st episode ofschizophrenia (n = 10) treated with risperidon and mentally healthy control group (n = 10) with ¹⁸FDG positron emission tomography (PET). Four patients were assessed before and after 4-6 weeks of risperidone therapy. Image analysis was performed using Statistical Parametric Mapping 99 (SPM99). Results: SPM group analysis revealed increased ¹⁸FDG uptake in the schizophrenia patients during antipsychotic therapy or in antipsychotic naive state in cerebellum, temporal cortex and anterior cingulum. Risperidone therapy led to decrease ¹⁸FDG uptake in cerebellum, temporal cortex, anterior cingulum and to increase in parietal cortex. Conclusions: Brain glucose abnormalities in patients with schizophrenia support hypothesis about cortico-subcortico-cerebellar dysfunction in schizophrenia. Risperidone therapy can partially repair this dysfunction.