Résumé
We report here the first demonstration of dengue virus infection and vasoactive cytokine response of a cell of the mast cell/basophil lineage. Infection of KU812 cells was dependent on dengue-specific antibody and gave rise to infectious virions. This antibody-enhanced dengue virus infection triggered a four- to fivefold increase in the release of interleukin-1β (IL- 1β) and a modest increase for IL-6 but not for an alternate cytokine, granulocyte-macrophage colony-stimulating factor. The results suggest a potential role for mast cells/basophils in the pathogenesis of dengue virus- induced disease.
| Langue d'origine | English |
|---|---|
| Pages (de-à) | 7146-7150 |
| Nombre de pages | 5 |
| Journal | Journal of Virology |
| Volume | 74 |
| Numéro de publication | 15 |
| DOI | |
| Statut de publication | Published - août 2000 |
ASJC Scopus Subject Areas
- Microbiology
- Immunology
- Insect Science
- Virology
ODD de l’ONU
Cette action contribue à la réalisation des objectifs de développement durable suivants
