Résumé
Background: Craving or the "urge to consume" is a characteristic of bulimic eating disorders and addictions. Dysfunction of the dorsolateral prefrontal cortex (DLPFC) is associated with craving. We investigated whether stimulation of the DLPFC reduces food craving in people with a bulimic-type eating disorder. Methods: Thirty-eight people with bulimic-type eating disorders were randomly allocated to receive one session of real or sham high-frequency repetitive transcranial magnetic stimulation (rTMS) to the left DLPFC in a double-blind procedure. Outcome measures included self-reported food craving immediately after the stimulation session and frequency of bingeing over a 24-hour follow-up period. Results: Compared with sham control, real rTMS was associated with decreased self-reported urge to eat and fewer binge-eating episodes over the 24 hours following stimulation. Conclusions: High-frequency rTMS of the left DLPFC lowers cue-induced food cravings in people with a bulimic eating disorder and may reduce binge eating. These results provide a rationale for exploring rTMS as a treatment for bulimic eating disorders.
Langue d'origine | English |
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Pages (de-à) | 793-795 |
Nombre de pages | 3 |
Journal | Biological Psychiatry |
Volume | 67 |
Numéro de publication | 8 |
DOI | |
Statut de publication | Published - avr. 15 2010 |
Publié à l'externe | Oui |
Note bibliographique
Funding Information:Frederique Van den Eynde is a research fellow supported by the Marie Curie Research Training Network INTACT (Individually Tailored Stepped Care for Women with Eating Disorders) ( MRTN-CT-2006-035988 ). Angelica M. Claudino was funded by Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES), Ministry of Education, Brazil , with a postdoctoral grant at the Institute of Psychiatry, King's College London, during 2008. Wagner Ribeiro was funded by CAPES, Ministry of Education, Brazil .
Funding Information:
The authors acknowledge support from the National Institute for Health Research Specialist Biomedical Research Centre for Mental Health award to the South London and Maudsley National Health Service Foundation Trust and the Institute of Psychiatry, King's College London.
ASJC Scopus Subject Areas
- Biological Psychiatry