Reversal of hyperventilation induced hyperlactatemia by acetazolamide

D. T. Zborowska-Sluis; R. I. Ogilvie; G. A. Klassen

doi:10.1016/0034-5687(70)90108-8

Reversal of hyperventilation induced hyperlactatemia by acetazolamide

D. T. Zborowska-Sluis, R. I. Ogilvie, G. A. Klassen

Résultat de recherche: Article › examen par les pairs

6 Citations (Scopus)

Résumé

Acetazolamide administration to hyperventilating dogs was found to both reverse and to prevent the associated hyperlactatemia. This inhibition of glycolysis was associated with a reversal of the hyperventilation induced alkalosis, an increase in P_CO2, and an increase in blood CO₂ content. A unique effect of these three variables on the control of the glycolytic rate as measured by a rise in arterial lactate concentration could not be identified.

Langue d'origine	English
Pages (de-à)	127-134
Nombre de pages	8
Journal	Respiration Physiology
Volume	11
Numéro de publication	1
DOI	https://doi.org/10.1016/0034-5687(70)90108-8
Statut de publication	Published - 1970
Publié à l'externe	Oui

Note bibliographique

Funding Information:
This work was supported by grants from the Muscular Dystrophy Association of Canada and the Medical Research Council of Canada, Grant M.T. 3238.

Funding Information:
Dr. D. T. Zborowska-Sluis was supported by a fellowship from the Muscular Dystrophy Association of Canada, Dr. R. 1. Ogilvie is a fellow of the Canadian Foundation for the Advancement of Therapeutics, and Dr. G. A. Klassen is a John and Mary R. Markle Scholar.

ASJC Scopus Subject Areas

Physiology
Pulmonary and Respiratory Medicine

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10.1016/0034-5687(70)90108-8

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abstract = "Acetazolamide administration to hyperventilating dogs was found to both reverse and to prevent the associated hyperlactatemia. This inhibition of glycolysis was associated with a reversal of the hyperventilation induced alkalosis, an increase in PCO2, and an increase in blood CO2 content. A unique effect of these three variables on the control of the glycolytic rate as measured by a rise in arterial lactate concentration could not be identified.",

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AU - Zborowska-Sluis, D. T.

AU - Ogilvie, R. I.

AU - Klassen, G. A.

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AB - Acetazolamide administration to hyperventilating dogs was found to both reverse and to prevent the associated hyperlactatemia. This inhibition of glycolysis was associated with a reversal of the hyperventilation induced alkalosis, an increase in PCO2, and an increase in blood CO2 content. A unique effect of these three variables on the control of the glycolytic rate as measured by a rise in arterial lactate concentration could not be identified.

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Reversal of hyperventilation induced hyperlactatemia by acetazolamide

Résumé

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ASJC Scopus Subject Areas

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