Review of the geant4-dna simulation toolkit for radiobiological applications at the cellular and dna level

Ioanna Kyriakou, Dousatsu Sakata, Hoang Ngoc Tran, Yann Perrot, Wook Geun Shin, Nathanael Lampe, Sara Zein, Marie Claude Bordage, Susanna Guatelli, Carmen Villagrasa, Dimitris Emfietzoglou, Sébastien Incerti

Résultat de recherche: Articleexamen par les pairs

85 Citations (Scopus)

Résumé

The Geant4-DNA low energy extension of the Geant4 Monte Carlo (MC) toolkit is a continuously evolving MC simulation code permitting mechanistic studies of cellular radiobiological effects. Geant4-DNA considers the physical, chemical, and biological stages of the action of ionizing radiation (in the form of x- and -ray photons, electrons and __-rays, hadrons, _-particles, and a set of heavier ions) in living cells towards a variety of applications ranging from predicting radiotherapy outcomes to radiation protection both on earth and in space. In this work, we provide a brief, yet concise, overview of the progress that has been achieved so far concerning the different physical, physicochemical, chemical, and biological models implemented into Geant4-DNA, highlighting the latest developments. Specifically, the “dnadamage1” and “molecularDNA” applications which enable, for the first time within an open-source platform, quantitative predictions of early DNA damage in terms of single-strand-breaks (SSBs), double-strand-breaks (DSBs), and more complex clustered lesions for different DNA structures ranging from the nucleotide level to the entire genome. These developments are critically presented and discussed along with key benchmarking results. The Geant4-DNA toolkit, through its different set of models and functionalities, offers unique capabilities for elucidating the problem of radiation quality or the relative biological effectiveness (RBE) of different ionizing radiations which underlines nearly the whole spectrumof radiotherapeutic modalities, from external high-energy hadron beams to internal low-energy gamma and beta emitters that are used in brachytherapy sources and radiopharmaceuticals, respectively.

Langue d'origineEnglish
Numéro d'article35
JournalCancers
Volume14
Numéro de publication1
DOI
Statut de publicationPublished - janv. 1 2022
Publié à l'externeOui

Note bibliographique

Funding Information:
The authors wish to thank the European Space Agency for its support to Geant4-DNA under contract “BioRad III”4000132935/21/NL/CRS (2021-2023), and CNRS/IN2P3, in particular for its support to the “NanoGold2” PICS/IEA #8235 between Ioannina U., Greece, and CNRS/IN2P3, France. The authors would like to acknowledge the financial support of the Australian Research Council (DP170100967). D. Emfietzoglou and I. Kyriakou acknowledge financial support from the European Space Agency (ESA Contract No. 4000126645/19/NL/BW). D. Sakata acknowledges financial support from JSPS KAKENHI, Japan, grant number JP20K16840.

Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.

ASJC Scopus Subject Areas

  • Oncology
  • Cancer Research

PubMed: MeSH publication types

  • Journal Article
  • Review

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Kyriakou, I., Sakata, D., Tran, H. N., Perrot, Y., Shin, W. G., Lampe, N., Zein, S., Bordage, M. C., Guatelli, S., Villagrasa, C., Emfietzoglou, D., & Incerti, S. (2022). Review of the geant4-dna simulation toolkit for radiobiological applications at the cellular and dna level. Cancers, 14(1), Article 35. https://doi.org/10.3390/cancers14010035