Risk of false-positive prenatal diagnosis using interphase FISH testing: Hybridization of alpha-satellite X probe to chromosome 19

Elizabeth J.T. Winsor, Sarah Dyack, E. Martha Wood-Burgess, Greg Ryan

Résultat de recherche: Articleexamen par les pairs

16 Citations (Scopus)

Résumé

FISH analysis of uncultured interphase amniotic fluid cells from a male fetus revealed two signals using an alpha-satellite X-chromosome DNA probe. One of the signals was much smaller than the other. It was subsequently shown that the normal sized signal was located on the X chromosome and the smaller signal was located at the centromere of chromosome 19. This hybridization pattern was confirmed in the newborn infant and in his phenotypically normal father. The use of alpha-satellite DNA probes on interphase cells could result in false-positive errors due to rare variants such as the X-chromosome alpha-satellite found on chromosome 19 in our patient.

Langue d'origineEnglish
Pages (de-à)832-836
Nombre de pages5
JournalPrenatal Diagnosis
Volume19
Numéro de publication9
DOI
Statut de publicationPublished - 1999
Publié à l'externeOui

ASJC Scopus Subject Areas

  • Obstetrics and Gynaecology
  • Genetics(clinical)

PubMed: MeSH publication types

  • Case Reports
  • Journal Article

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