Seeing over the horizon - Targeting the endocannabinoid system for the treatment of ocular disease

Elizabeth A. Cairns; J. Thomas Toguri; Richard F. Porter; Anna Maria Szczesniak; Melanie E.M. Kelly

doi:10.1515/jbcpp-2015-0065

Seeing over the horizon - Targeting the endocannabinoid system for the treatment of ocular disease

Elizabeth A. Cairns, J. Thomas Toguri, Richard F. Porter, Anna Maria Szczesniak, Melanie E.M. Kelly

Medicine

Résultat de recherche: Review article › examen par les pairs

23 Citations (Scopus)

Résumé

The observation that marijuana reduces intraocular pressure was made by Hepler and Frank in the 1970s. Since then, there has been a significant body of work investigating cannabinoids for their potential use as therapeutics. To date, no endocannabinoid system (ECS)-modulating drug has been approved for clinical use in the eye; however, recent advances in our understanding of the ECS, as well as new pharmacological tools, has renewed interest in the development of ocular ECS-based therapeutics. This review summarizes the current state-of-affairs for the use of ECS-modulating drugs for the treatment of glaucoma and ocular inflammatory and ischemic disease.

Langue d'origine	English
Pages (de-à)	253-265
Nombre de pages	13
Journal	Journal of Basic and Clinical Physiology and Pharmacology
Volume	27
Numéro de publication	3
DOI	https://doi.org/10.1515/jbcpp-2015-0065
Statut de publication	Published - mai 1 2016

Note bibliographique

Funding Information:
The writing of this review was supported by a grant from the Canadian Institutes of Health Research (CIHR) MOP-97768 (M.E.M.K) and MOP-97769

Publisher Copyright:
© 2016 by De Gruyter.

ASJC Scopus Subject Areas

Physiology
Pharmacology
Drug Discovery

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10.1515/jbcpp-2015-0065

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abstract = "The observation that marijuana reduces intraocular pressure was made by Hepler and Frank in the 1970s. Since then, there has been a significant body of work investigating cannabinoids for their potential use as therapeutics. To date, no endocannabinoid system (ECS)-modulating drug has been approved for clinical use in the eye; however, recent advances in our understanding of the ECS, as well as new pharmacological tools, has renewed interest in the development of ocular ECS-based therapeutics. This review summarizes the current state-of-affairs for the use of ECS-modulating drugs for the treatment of glaucoma and ocular inflammatory and ischemic disease.",

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AU - Kelly, Melanie E.M.

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Seeing over the horizon - Targeting the endocannabinoid system for the treatment of ocular disease

Résumé

Note bibliographique

ASJC Scopus Subject Areas

Accès au document

Autres fichiers et liens

Empreinte numérique

Citer