Sensitivity patterns of bacterial pathogens isolated from blood cultures of under-five children with pneumonia and clinical sepsis

Sufia Islam, Ashiqur Rahman Akand, Tasnova Tasnim Nova, Christian Lehmann, Mohammod Jobayer Chisti

Résultat de recherche: Articleexamen par les pairs

1 Citation (Scopus)

Résumé

Treatment options for pneumonia and sepsis by antibiotics are limited due to the development of multidrug-resistant bacterial strains. This unmatched case-control study determined the antibiotic sensitivity against bacterial isolates obtained from septic and nonseptic children with pneumonia. Children of either sex aged 0–59 months with a history of cough or shortness of breath and radiologically confirmed pneumonia were enrolled in this study. Cases with clinical signs of sepsis at admission (n = 151) were compared to cases without sepsis as controls (n = 107). A total of 205 children had a performance of blood culture, with 123 children suffering from clinical sepsis. Blood cultures showed bacterial growth in 19% of the septic samples, with 8% coagulase-negative staphylococci and 2.4% Acinetobacter species. Only 1.6% of the cases were infected by Streptococcus pneumonia, Haemophilus influenzae, Salmonella typhi and Klebsiella. In contrast, children without sepsis presented positive blood cultures with growth of Salmonella typhi in 2.4% of the cases and growth of Klebsiella in 1.2%. Bacteria were sensitive to imipenem in 100% of the cases (86% for meropenem, 83% for ceftazidime and 76% for ciprofloxacin). The mortality rate was significantly higher in children with pneumonia complicated by sepsis (odds ratio (OR) = 3.02, 95% confidence interval (CI), 1.11–8.64, p < 0.027). Knowledge about specific laboratory characteristics in children with pneumonia will facilitate an early diagnosis and treatment of sepsis and reduce mortality.

Langue d'origineEnglish
Numéro d'article450
JournalLife
Volume11
Numéro de publication5
DOI
Statut de publicationPublished - mai 2021

Note bibliographique

Funding Information:
Acknowledgments: This research was supported by the International Centre for Diarrhoeal Disease Research, Bangladesh. We sincerely thank the parents of children for their involvement in this study. We thank the governments of Australia, Bangladesh, Canada, Sweden and the UK for providing core or unrestricted support to the International Centre for Diarrhoeal Disease Research, Bangladesh.

Publisher Copyright:
© 2021 by the authors. Licensee MDPI, Basel, Switzerland.

ASJC Scopus Subject Areas

  • Ecology, Evolution, Behavior and Systematics
  • General Biochemistry,Genetics and Molecular Biology
  • Space and Planetary Science
  • Palaeontology

PubMed: MeSH publication types

  • Journal Article

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