Serum testosterone concentrations are not associated with frailty in naturally ageing and testosterone-deficient older C57Bl/6 mice

Stefan D. Heinze-Milne; Shubham Banga; Judith Godin; Susan E. Howlett

doi:10.1016/j.mad.2022.111638

Serum testosterone concentrations are not associated with frailty in naturally ageing and testosterone-deficient older C57Bl/6 mice

Stefan D. Heinze-Milne, Shubham Banga, Judith Godin, Susan E. Howlett

Résultat de recherche: Article › examen par les pairs

1 Citation (Scopus)

Résumé

This study investigated how serum testosterone related to frailty in ageing male C57Bl/6 mice with or without lifelong testosterone deficiency. Mice underwent a sham surgery (n = 10) or gonadectomy (n = 11, GDX) at 4-weeks and then aged. Frailty scores (31-item frailty index) and testosterone were measured between 18- to 24-months of age. Age predicted frailty (p < 0.0001), but serum testosterone did not (p = 0.357). Life expectancy (AFRAID clock) and biologic age (FRIGHT clock) were not significantly different between groups (p = 0.485 and 0.142). The fact that lifelong testosterone deficiency did not exacerbate frailty suggests that low testosterone alone does not potently drive frailty in males.

Langue d'origine	English
Numéro d'article	111638
Journal	Mechanisms of Ageing and Development
Volume	203
DOI	https://doi.org/10.1016/j.mad.2022.111638
Statut de publication	Published - avr. 2022
Publié à l'externe	Oui

Note bibliographique

Funding Information:
The authors thank Peter Nicholl for his expert technical assistance. This work was supported by the Canadian Institutes of Health Research (PGT 162462 & 155961 ) and the Heart and Stroke Foundation of Canada ( G-19–0026260 ). SHM is supported by the Nova Scotia Health Research Foundation’s Scotia Scholars Award , a Level II Killam Predoctoral Scholarship, the Dalhousie Medical Research Foundation’s MacDonald Graduate Studentship , the Canadian Institutes of Health Research Doctoral Research Award , and Dalhousie University’s President’s Award . SB is supported by the Dalhousie Medical Research Foundation’s MacDonald Graduate Studentship, the Dalhousie Faculty of Medicine Graduate Studentship Award , and Heart and Stroke Canada’s Bright Red Award .

Publisher Copyright:
© 2022 The Authors

ASJC Scopus Subject Areas

Ageing
Developmental Biology

PubMed: MeSH publication types

Journal Article
Research Support, Non-U.S. Gov't

ODD de l’ONU

Cette action contribue à la réalisation des objectifs de développement durable suivants

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10.1016/j.mad.2022.111638

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abstract = "This study investigated how serum testosterone related to frailty in ageing male C57Bl/6 mice with or without lifelong testosterone deficiency. Mice underwent a sham surgery (n = 10) or gonadectomy (n = 11, GDX) at 4-weeks and then aged. Frailty scores (31-item frailty index) and testosterone were measured between 18- to 24-months of age. Age predicted frailty (p < 0.0001), but serum testosterone did not (p = 0.357). Life expectancy (AFRAID clock) and biologic age (FRIGHT clock) were not significantly different between groups (p = 0.485 and 0.142). The fact that lifelong testosterone deficiency did not exacerbate frailty suggests that low testosterone alone does not potently drive frailty in males.",

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N1 - Funding Information: The authors thank Peter Nicholl for his expert technical assistance. This work was supported by the Canadian Institutes of Health Research (PGT 162462 & 155961 ) and the Heart and Stroke Foundation of Canada ( G-19–0026260 ). SHM is supported by the Nova Scotia Health Research Foundation’s Scotia Scholars Award , a Level II Killam Predoctoral Scholarship, the Dalhousie Medical Research Foundation’s MacDonald Graduate Studentship , the Canadian Institutes of Health Research Doctoral Research Award , and Dalhousie University’s President’s Award . SB is supported by the Dalhousie Medical Research Foundation’s MacDonald Graduate Studentship, the Dalhousie Faculty of Medicine Graduate Studentship Award , and Heart and Stroke Canada’s Bright Red Award . Publisher Copyright: © 2022 The Authors

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AB - This study investigated how serum testosterone related to frailty in ageing male C57Bl/6 mice with or without lifelong testosterone deficiency. Mice underwent a sham surgery (n = 10) or gonadectomy (n = 11, GDX) at 4-weeks and then aged. Frailty scores (31-item frailty index) and testosterone were measured between 18- to 24-months of age. Age predicted frailty (p < 0.0001), but serum testosterone did not (p = 0.357). Life expectancy (AFRAID clock) and biologic age (FRIGHT clock) were not significantly different between groups (p = 0.485 and 0.142). The fact that lifelong testosterone deficiency did not exacerbate frailty suggests that low testosterone alone does not potently drive frailty in males.

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Serum testosterone concentrations are not associated with frailty in naturally ageing and testosterone-deficient older C57Bl/6 mice

Résumé

Note bibliographique

ASJC Scopus Subject Areas

PubMed: MeSH publication types

ODD de l’ONU

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