Résumé
The use of the non-steroidal anti-inflammatory drugs such as dipyrone is so widespread that this drug and its metabolites have been detected in effluents and surface water. This study aimed to evaluate the potential toxic effects of dipyrone on the aquatic environment, using a native fish species, Rhamdia quelen. Fish were exposed to three concentrations of dipyrone, 0.5, 5 and 50. γg/L, in the water for 15 days, and hematological, biochemical, genetic and morphological biomarkers were evaluated. The glutathione S-transferase activity decreased in the highest concentration in relation to the control group. In addition, hematocrit, red blood cells and thrombocyte counts were decreased in all three exposed groups in relation to the control group. The comet assay showed DNA damage at the lowest concentration of dipyrone and significant kidney damage. Those results suggest that a constant exposure of aquatic organisms to dipyrone presents potential toxic effects.
| Langue d'origine | English |
|---|---|
| Pages (de-à) | 342-349 |
| Nombre de pages | 8 |
| Journal | Ecotoxicology and Environmental Safety |
| Volume | 74 |
| Numéro de publication | 3 |
| DOI | |
| Statut de publication | Published - mars 2011 |
| Publié à l'externe | Oui |
Note bibliographique
Funding Information:This research was partially supported by the CAPES, CNPq and Fundação Araucária, Brazil.
Funding Information:
This research was partially supported by the Brazilian government (CNPq, CAPES and Fundação Araucária). All the procedures of this study were carried out in accordance with the Guide for the Care and Use of Laboratory Animals (Canadian Council on Animal Care) and the animal protocol approved by Paraná Federal University´s ethical committee for animal experimentation.
ASJC Scopus Subject Areas
- Pollution
- Public Health, Environmental and Occupational Health
- Health, Toxicology and Mutagenesis
ODD de l’ONU
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