Subchronic toxic effects of tributyltin (TBT) and inorganic lead (PbII) in rats

Helena Cristina Da Silva De Assis; Alejandro Sánchez-Chardi; Renata Cristiane Dos Reis; Lilian Nicaretta; Cinthia Mencinauski; Sibelle Christine Glaser Jakobi; Paulo Henrique Da Silva; Aleksander Roberto Zampronio; Emillien Pelletier; Ciro Alberto De Oliveira Ribeiro

doi:10.1016/j.etap.2004.05.006

Subchronic toxic effects of tributyltin (TBT) and inorganic lead (PbII) in rats

Helena Cristina Da Silva De Assis, Alejandro Sánchez-Chardi, Renata Cristiane Dos Reis, Lilian Nicaretta, Cinthia Mencinauski, Sibelle Christine Glaser Jakobi, Paulo Henrique Da Silva, Aleksander Roberto Zampronio, Emillien Pelletier, Ciro Alberto De Oliveira Ribeiro

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11 Citations (Scopus)

Résumé

This study evaluated the toxic effects of two doses of inorganic lead (PbII) and tributyltin (TBT), separately and together in different exposure times (30 and 60 days) in rats. After exposure, liver, kidney, brain and blood were sampled for histopathological, hematological and enzymatic analysis. The number of peritoneal cells and lipopolysaccharide (LPS)-induced neutrophil migration after exposure was also analyzed. The liver presented necrotic areas in all exposed individuals while hematological and enzymatic parameters showed no changes. TBT, but not PbII, reduced the number of resident peritoneal macrophages. The combination of both toxicants abolished TBT effects at lower doses and even increased the number of macrophages at higher doses. The neutrophil migration was increased by lead and lead associated with TBT. These results confirm the potential hepatotoxicity of these compounds and they may have antagonistic effects on the immune cells when administered alone. The combination of toxicants induced an increased inflammatory response suggesting that lead effects may prevail over TBT reduction on macrophage number.

Langue d'origine	English
Pages (de-à)	113-120
Nombre de pages	8
Journal	Environmental Toxicology and Pharmacology
Volume	19
Numéro de publication	1
DOI	https://doi.org/10.1016/j.etap.2004.05.006
Statut de publication	Published - janv. 2005
Publié à l'externe	Oui

Note bibliographique

Funding Information:
R.C.R was a recipient of fellowships from Conselho Nacional de Desenvolvimento Cientı́fico e Tecnológico (CNPq, PIBIC, 2001–2002). A.S.C. was supported by a BE grant from Generalitat Catalunya (Autonomus Government of Catalonia).

ASJC Scopus Subject Areas

Toxicology
Pharmacology
Health, Toxicology and Mutagenesis

PubMed: MeSH publication types

Journal Article

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10.1016/j.etap.2004.05.006

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Da Silva De Assis, H. C., Sánchez-Chardi, A., Dos Reis, R. C., Nicaretta, L., Mencinauski, C., Jakobi, S. C. G., Da Silva, P. H., Zampronio, A. R., Pelletier, E., & De Oliveira Ribeiro, C. A. (2005). Subchronic toxic effects of tributyltin (TBT) and inorganic lead (PbII) in rats. Environmental Toxicology and Pharmacology, 19(1), 113-120. https://doi.org/10.1016/j.etap.2004.05.006

Da Silva De Assis, HC, Sánchez-Chardi, A, Dos Reis, RC, Nicaretta, L, Mencinauski, C, Jakobi, SCG, Da Silva, PH, Zampronio, AR, Pelletier, E & De Oliveira Ribeiro, CA 2005, 'Subchronic toxic effects of tributyltin (TBT) and inorganic lead (PbII) in rats', Environmental Toxicology and Pharmacology, vol. 19, n° 1, pp. 113-120. https://doi.org/10.1016/j.etap.2004.05.006

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abstract = "This study evaluated the toxic effects of two doses of inorganic lead (PbII) and tributyltin (TBT), separately and together in different exposure times (30 and 60 days) in rats. After exposure, liver, kidney, brain and blood were sampled for histopathological, hematological and enzymatic analysis. The number of peritoneal cells and lipopolysaccharide (LPS)-induced neutrophil migration after exposure was also analyzed. The liver presented necrotic areas in all exposed individuals while hematological and enzymatic parameters showed no changes. TBT, but not PbII, reduced the number of resident peritoneal macrophages. The combination of both toxicants abolished TBT effects at lower doses and even increased the number of macrophages at higher doses. The neutrophil migration was increased by lead and lead associated with TBT. These results confirm the potential hepatotoxicity of these compounds and they may have antagonistic effects on the immune cells when administered alone. The combination of toxicants induced an increased inflammatory response suggesting that lead effects may prevail over TBT reduction on macrophage number.",

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AU - Nicaretta, Lilian

AU - Mencinauski, Cinthia

AU - Jakobi, Sibelle Christine Glaser

AU - Da Silva, Paulo Henrique

AU - Zampronio, Aleksander Roberto

AU - Pelletier, Emillien

AU - De Oliveira Ribeiro, Ciro Alberto

N1 - Funding Information: R.C.R was a recipient of fellowships from Conselho Nacional de Desenvolvimento Cientı́fico e Tecnológico (CNPq, PIBIC, 2001–2002). A.S.C. was supported by a BE grant from Generalitat Catalunya (Autonomus Government of Catalonia).

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N2 - This study evaluated the toxic effects of two doses of inorganic lead (PbII) and tributyltin (TBT), separately and together in different exposure times (30 and 60 days) in rats. After exposure, liver, kidney, brain and blood were sampled for histopathological, hematological and enzymatic analysis. The number of peritoneal cells and lipopolysaccharide (LPS)-induced neutrophil migration after exposure was also analyzed. The liver presented necrotic areas in all exposed individuals while hematological and enzymatic parameters showed no changes. TBT, but not PbII, reduced the number of resident peritoneal macrophages. The combination of both toxicants abolished TBT effects at lower doses and even increased the number of macrophages at higher doses. The neutrophil migration was increased by lead and lead associated with TBT. These results confirm the potential hepatotoxicity of these compounds and they may have antagonistic effects on the immune cells when administered alone. The combination of toxicants induced an increased inflammatory response suggesting that lead effects may prevail over TBT reduction on macrophage number.

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Subchronic toxic effects of tributyltin (TBT) and inorganic lead (PbII) in rats

Résumé

Note bibliographique

ASJC Scopus Subject Areas

PubMed: MeSH publication types

Accès au document

Autres fichiers et liens

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