TY - JOUR
T1 - Ten-year incident osteoporosis-related fractures in the population-based Canadian Multicentre Osteoporosis Study - Comparing site and age-specific risks in women and men
AU - the CaMOS Research Group
AU - Prior, Jerilynn C.
AU - Langsetmo, Lisa
AU - Lentle, Brian C.
AU - Berger, Claudie
AU - Goltzman, David
AU - Kovacs, Christopher S.
AU - Kaiser, Stephanie M.
AU - Adachi, Jonathan D.
AU - Papaioannou, Alexandra
AU - Anastassiades, Tassos
AU - Towheed, Tanveer
AU - Josse, Robert G.
AU - Brown, Jacques P.
AU - Leslie, William D.
AU - Kreiger, Nancy
AU - Tenenhouse, Alan
AU - Poliquin, Suzette
AU - Godmaire, Suzanne
AU - Dumont, Silvia
AU - Lentle, Brian
AU - Mailloux, Louise
AU - Bastien, Diane
AU - Robertson, Loralee
AU - Joyce, Carol
AU - Sheppard, Emma
AU - Kirkland, Susan
AU - Kaiser, Stephanie
AU - Stanfield, Barbara
AU - Bessette, Louis
AU - Gendreau, Marc
AU - Hopman, Wilma
AU - Rees-Milton, Karen
AU - Jamal, Sophie
AU - Cheung, Angela M.
AU - Gardner-Bray, Barbara
AU - Pickard, Laura
AU - Wojciech, P.
AU - Olszynski,
AU - Davison, K. Shawn
AU - Thingvold, Jola
AU - Hanley, David A.
AU - Boyd, Steven
AU - Allan, Jane
AU - Patel, Millan
AU - Vigna, Yvette M.
AU - Andjelic, Nerkeza
AU - ElhamRahme,
AU - Richards, Brent
AU - Morin, Suzanne
AU - Jackson, Stuart
N1 - Funding Information:
CaMos is currently funded by: Canadian Institutes of Health Research (CIHR) , Amgen , Dairy Farmers of Canada , Merck , Eli Lilly , and Novartis .
Publisher Copyright:
© 2014 Elsevier Inc.
PY - 2015
Y1 - 2015
N2 - Background: Population-based incident fracture data aid fracture prevention and therapy decisions. Our purpose was to describe 10-year site-specific cumulative fracture incidence by sex, age at baseline, and degree of trauma with/without consideration of competing mortality in the Canadian Multicentre Osteoporosis Study adult cohort. Methods: Incident fractures and mortality were identified by annual postal questionnaires to the participant or proxy respondent. Date, site and circumstance of fracture were gathered from structured interviews and medical records. Fracture analyses were stratified by sex and age at baseline and used both Kaplan-Meier and competing mortality methods. Results: The baseline (1995-97) cohort included 6314 women and 2789 men (aged 25-84. years; mean. ±. SD 62. ±. 12 and 59. ±. 14, respectively), with 4322 (68%) women and 1732 (62%) men followed to year-10. At least one incident fracture occurred for 930 women (14%) and 247 men (9%). Competing mortality exceeded fracture risk for men aged 65. +. years at baseline. Age was a strong predictor of incident fractures especially fragility fractures, with higher age gradients for women vs. men. Major osteoporotic fracture (MOF) (hip, clinical spine, forearm, humerus) accounted for 41-74% of fracture risk by sex/age strata; in women all MOF sites showed age-related increases but in men only hip was clearly age-related. The most common fractures were the forearm for women and the ribs for men. Hip fracture incidence was the highest for the 75-84. year baseline age-group with no significant difference between women 7.0% (95% CI 5.3, 8.9) and men 7.0% (95% CI 4.4, 10.3). Interpretation: There are sex differences in the predominant sites and age-gradients of fracture. In older men, competing mortality exceeds cumulative fracture risk.
AB - Background: Population-based incident fracture data aid fracture prevention and therapy decisions. Our purpose was to describe 10-year site-specific cumulative fracture incidence by sex, age at baseline, and degree of trauma with/without consideration of competing mortality in the Canadian Multicentre Osteoporosis Study adult cohort. Methods: Incident fractures and mortality were identified by annual postal questionnaires to the participant or proxy respondent. Date, site and circumstance of fracture were gathered from structured interviews and medical records. Fracture analyses were stratified by sex and age at baseline and used both Kaplan-Meier and competing mortality methods. Results: The baseline (1995-97) cohort included 6314 women and 2789 men (aged 25-84. years; mean. ±. SD 62. ±. 12 and 59. ±. 14, respectively), with 4322 (68%) women and 1732 (62%) men followed to year-10. At least one incident fracture occurred for 930 women (14%) and 247 men (9%). Competing mortality exceeded fracture risk for men aged 65. +. years at baseline. Age was a strong predictor of incident fractures especially fragility fractures, with higher age gradients for women vs. men. Major osteoporotic fracture (MOF) (hip, clinical spine, forearm, humerus) accounted for 41-74% of fracture risk by sex/age strata; in women all MOF sites showed age-related increases but in men only hip was clearly age-related. The most common fractures were the forearm for women and the ribs for men. Hip fracture incidence was the highest for the 75-84. year baseline age-group with no significant difference between women 7.0% (95% CI 5.3, 8.9) and men 7.0% (95% CI 4.4, 10.3). Interpretation: There are sex differences in the predominant sites and age-gradients of fracture. In older men, competing mortality exceeds cumulative fracture risk.
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U2 - 10.1016/j.bone.2014.10.026
DO - 10.1016/j.bone.2014.10.026
M3 - Article
C2 - 25451323
AN - SCOPUS:84912051938
SN - 8756-3282
VL - 71
SP - 237
EP - 243
JO - Bone
JF - Bone
ER -
