The BDNF Val66Met polymorphism moderates the relationship between cognitive reserve and executive function

D. D. Ward; M. J. Summers; N. L. Saunders; K. Ritchie; J. J. Summers; J. C. Vickers

doi:10.1038/tp.2015.82

The BDNF Val66Met polymorphism moderates the relationship between cognitive reserve and executive function

D. D. Ward, M. J. Summers, N. L. Saunders, K. Ritchie, J. J. Summers, J. C. Vickers

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33 Citations (Scopus)

Résumé

The concept of cognitive reserve (CR) has been proposed to account for observed discrepancies between pathology and its clinical manifestation due to underlying differences in brain structure and function. In 433 healthy older adults participating in the Tasmanian Healthy Brain Project, we investigated whether common polymorphic variations in apolipoprotein E (APOE) or brain-derived neurotrophic factor (BDNF) influenced the association between CR contributors and cognitive function in older adults. We show that BDNF Val66Met moderates the association between CR and executive function. CR accounted for 8.5% of the variance in executive function in BDNF Val homozygotes, but CR was a nonsignificant predictor in BDNF Met carriers. APOE polymorphisms were not linked to the influence of CR on cognitive function. This result implicates BDNF in having an important role in capacity for building or accessing CR.

Langue d'origine	English
Numéro d'article	e590
Journal	Translational Psychiatry
Volume	5
Numéro de publication	6
DOI	https://doi.org/10.1038/tp.2015.82
Statut de publication	Published - juin 30 2015
Publié à l'externe	Oui

Note bibliographique

Funding Information:
This research was supported by the National Health and Medical Research Council of Australia Project Grant (No: 1003645) and the J.O. and J.R. Wicking Trust (Equity Trustees).

Funding Information:
Associate Professor MJ Summers reports personal fees from Eli Lilly (Australia) Pty Ltd and grants from Novotech Pty Ltd, outside the submitted work. The remaining authors declare no conflict of interest.

ASJC Scopus Subject Areas

Psychiatry and Mental health
Cellular and Molecular Neuroscience
Biological Psychiatry

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10.1038/tp.2015.82

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abstract = "The concept of cognitive reserve (CR) has been proposed to account for observed discrepancies between pathology and its clinical manifestation due to underlying differences in brain structure and function. In 433 healthy older adults participating in the Tasmanian Healthy Brain Project, we investigated whether common polymorphic variations in apolipoprotein E (APOE) or brain-derived neurotrophic factor (BDNF) influenced the association between CR contributors and cognitive function in older adults. We show that BDNF Val66Met moderates the association between CR and executive function. CR accounted for 8.5% of the variance in executive function in BDNF Val homozygotes, but CR was a nonsignificant predictor in BDNF Met carriers. APOE polymorphisms were not linked to the influence of CR on cognitive function. This result implicates BDNF in having an important role in capacity for building or accessing CR.",

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AU - Vickers, J. C.

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The BDNF Val66Met polymorphism moderates the relationship between cognitive reserve and executive function

Résumé

Note bibliographique

ASJC Scopus Subject Areas

ODD de l’ONU

Accès au document

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