The calcium-magnesium interaction in the process of release of noradrenaline by nicotine

S. Jayasundar; M. M. Vohra

doi:10.1139/y77-184

The calcium-magnesium interaction in the process of release of noradrenaline by nicotine

S. Jayasundar, M. M. Vohra

Medicine

Medicine

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3 Citations (Scopus)

Résumé

The calcium-magnesium (Ca²⁺-Mg²⁺) interaction in the process of nicotine-induced release of [³H]noradrenaline ([³H]NA) from rat isolated vas deferens was studied. Increasing extracellular concentrations of Mg²⁺ caused a dose-dependent depression of release of [³H]NA by nicotine, and this inhibitory effect of Mg²⁺ was overcome by raising the concentration of Ca²⁺. It is concluded that Mg²⁺ antagonizes the nicotine-induced increase in the Ca²⁺ influx into the adrenergic nerve terminals, and that nicotine acts on adrenergic neuronal membrane rather than intraneuronally to cause release of NA.

Langue d'origine	English
Pages (de-à)	1383-1386
Nombre de pages	4
Journal	Canadian Journal of Physiology and Pharmacology
Volume	55
Numéro de publication	6
DOI	https://doi.org/10.1139/y77-184
Statut de publication	Published - 1977

ASJC Scopus Subject Areas

Physiology
Pharmacology
Physiology (medical)

PubMed: MeSH publication types

Journal Article

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10.1139/y77-184

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title = "The calcium-magnesium interaction in the process of release of noradrenaline by nicotine",

abstract = "The calcium-magnesium (Ca2+-Mg2+) interaction in the process of nicotine-induced release of [3H]noradrenaline ([3H]NA) from rat isolated vas deferens was studied. Increasing extracellular concentrations of Mg2+ caused a dose-dependent depression of release of [3H]NA by nicotine, and this inhibitory effect of Mg2+ was overcome by raising the concentration of Ca2+. It is concluded that Mg2+ antagonizes the nicotine-induced increase in the Ca2+ influx into the adrenergic nerve terminals, and that nicotine acts on adrenergic neuronal membrane rather than intraneuronally to cause release of NA.",

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AB - The calcium-magnesium (Ca2+-Mg2+) interaction in the process of nicotine-induced release of [3H]noradrenaline ([3H]NA) from rat isolated vas deferens was studied. Increasing extracellular concentrations of Mg2+ caused a dose-dependent depression of release of [3H]NA by nicotine, and this inhibitory effect of Mg2+ was overcome by raising the concentration of Ca2+. It is concluded that Mg2+ antagonizes the nicotine-induced increase in the Ca2+ influx into the adrenergic nerve terminals, and that nicotine acts on adrenergic neuronal membrane rather than intraneuronally to cause release of NA.

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The calcium-magnesium interaction in the process of release of noradrenaline by nicotine

Résumé

ASJC Scopus Subject Areas

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Accès au document

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