The CDKAL1 rs7747752-Bile Acids Interaction Increased Risk of Gestational Diabetes Mellitus: A Nested Case-Control Study

Hui Wang; Jing Li; Junhong Leng; Weiqin Li; Jinnan Liu; Xiaoyan Yan; Zhijie Yu; Gang Hu; Ronald C.W. Ma; Zhongze Fang; Ying Wang; Xilin Yang

doi:10.3389/fendo.2022.808956

The CDKAL1 rs7747752-Bile Acids Interaction Increased Risk of Gestational Diabetes Mellitus: A Nested Case-Control Study

Hui Wang, Jing Li, Junhong Leng, Weiqin Li, Jinnan Liu, Xiaoyan Yan, Zhijie Yu, Gang Hu, Ronald C.W. Ma, Zhongze Fang, Ying Wang, Xilin Yang

Medicine

Résultat de recherche: Article › examen par les pairs

7 Citations (Scopus)

Résumé

Aims: The study aimed to explore additive interactions of CDKAL1 rs7747752 and GUDCA/DCA for GDM risk and whether the interactive effects on the risk of GDM was mediated via increasing lysophosphatidylcholines (LPC) 18:0 and/or saturated fatty acid (SFA) 16:0. Methods: A 1:1 age-matched study nested in a prospective cohort of pregnant women (207 pairs) was organized in Tianjin, China. Additive interactions were used to test interaction effects while mediation analyses and Sobel tests were used to test mediation effects of LPC18:0 and SFA16:0 between copresence of rs7747752 and low GUDCA/DCA, and GDM risk. Results: The CDKAL1 rs7747752 was associated with GDM (P<0.05). The rs7747752 C polymorphism markedly enhanced ORs of low GUDCA from 4.04 (0.72-22.8) to 9.02 (1.63-49.7) and low DCA from 1.67 (0.68-4.11) to 4.24 (1.84-9.76), both with significant additive interactions. Further adjustment for LPC18:0 attenuated the interactive effects of rs7747752 and low DCA, with a significant mediation effect (P=0.003). High SFA16:0 did not mediate the interactive effects of rs7747752 and low DCA/GUDCA on GDM risk. Conclusions: The CDKAL1 rs7747752 C carrier status and low GUDCA/DCA had significant additive interactions on the risk of GDM with the effect from interaction with DCA being partially mediated via increasing LPC18:0.

Langue d'origine	English
Numéro d'article	808956
Journal	Frontiers in Endocrinology
Volume	13
DOI	https://doi.org/10.3389/fendo.2022.808956
Statut de publication	Published - mars 10 2022

Note bibliographique

Funding Information:
The authors thank all the health professionals of Tianjin Antenatal Network for their involvement and contribution to the study. XYang was the guarantor of this manuscript.

Funding Information:
This work was supported by the National Natural Science Foundation of China (Grant No: 81870549), the National Key Research and Development Program of China (Grant No: 2019YFA0802300); the Engaged Talents of Guangdong Medical University in 2017 (Grant No: 2XB17028) and the Sailing Plan of Guangdong Province (Grant No: 4YF16001G).

Publisher Copyright:
Copyright © 2022 Wang, Li, Leng, Li, Liu, Yan, Yu, Hu, Ma, Fang, Wang and Yang.

ASJC Scopus Subject Areas

Endocrinology, Diabetes and Metabolism

PubMed: MeSH publication types

Journal Article

ODD de l’ONU

Cette action contribue à la réalisation des objectifs de développement durable suivants

Accès au document

10.3389/fendo.2022.808956

Autres fichiers et liens

Citer

@article{0dd52cea4efe4984940739e97f16e321,

title = "The CDKAL1 rs7747752-Bile Acids Interaction Increased Risk of Gestational Diabetes Mellitus: A Nested Case-Control Study",

abstract = "Aims: The study aimed to explore additive interactions of CDKAL1 rs7747752 and GUDCA/DCA for GDM risk and whether the interactive effects on the risk of GDM was mediated via increasing lysophosphatidylcholines (LPC) 18:0 and/or saturated fatty acid (SFA) 16:0. Methods: A 1:1 age-matched study nested in a prospective cohort of pregnant women (207 pairs) was organized in Tianjin, China. Additive interactions were used to test interaction effects while mediation analyses and Sobel tests were used to test mediation effects of LPC18:0 and SFA16:0 between copresence of rs7747752 and low GUDCA/DCA, and GDM risk. Results: The CDKAL1 rs7747752 was associated with GDM (P<0.05). The rs7747752 C polymorphism markedly enhanced ORs of low GUDCA from 4.04 (0.72-22.8) to 9.02 (1.63-49.7) and low DCA from 1.67 (0.68-4.11) to 4.24 (1.84-9.76), both with significant additive interactions. Further adjustment for LPC18:0 attenuated the interactive effects of rs7747752 and low DCA, with a significant mediation effect (P=0.003). High SFA16:0 did not mediate the interactive effects of rs7747752 and low DCA/GUDCA on GDM risk. Conclusions: The CDKAL1 rs7747752 C carrier status and low GUDCA/DCA had significant additive interactions on the risk of GDM with the effect from interaction with DCA being partially mediated via increasing LPC18:0.",

author = "Hui Wang and Jing Li and Junhong Leng and Weiqin Li and Jinnan Liu and Xiaoyan Yan and Zhijie Yu and Gang Hu and Ma, {Ronald C.W.} and Zhongze Fang and Ying Wang and Xilin Yang",

note = "Funding Information: The authors thank all the health professionals of Tianjin Antenatal Network for their involvement and contribution to the study. XYang was the guarantor of this manuscript. Funding Information: This work was supported by the National Natural Science Foundation of China (Grant No: 81870549), the National Key Research and Development Program of China (Grant No: 2019YFA0802300); the Engaged Talents of Guangdong Medical University in 2017 (Grant No: 2XB17028) and the Sailing Plan of Guangdong Province (Grant No: 4YF16001G). Publisher Copyright: Copyright {\textcopyright} 2022 Wang, Li, Leng, Li, Liu, Yan, Yu, Hu, Ma, Fang, Wang and Yang.",

year = "2022",

month = mar,

day = "10",

doi = "10.3389/fendo.2022.808956",

language = "English",

volume = "13",

journal = "Frontiers in Endocrinology",

issn = "1664-2392",

publisher = "Frontiers Media S. A.",

}

TY - JOUR

T1 - The CDKAL1 rs7747752-Bile Acids Interaction Increased Risk of Gestational Diabetes Mellitus

T2 - A Nested Case-Control Study

AU - Wang, Hui

AU - Li, Jing

AU - Leng, Junhong

AU - Li, Weiqin

AU - Liu, Jinnan

AU - Yan, Xiaoyan

AU - Yu, Zhijie

AU - Hu, Gang

AU - Ma, Ronald C.W.

AU - Fang, Zhongze

AU - Wang, Ying

AU - Yang, Xilin

N1 - Funding Information: The authors thank all the health professionals of Tianjin Antenatal Network for their involvement and contribution to the study. XYang was the guarantor of this manuscript. Funding Information: This work was supported by the National Natural Science Foundation of China (Grant No: 81870549), the National Key Research and Development Program of China (Grant No: 2019YFA0802300); the Engaged Talents of Guangdong Medical University in 2017 (Grant No: 2XB17028) and the Sailing Plan of Guangdong Province (Grant No: 4YF16001G). Publisher Copyright: Copyright © 2022 Wang, Li, Leng, Li, Liu, Yan, Yu, Hu, Ma, Fang, Wang and Yang.

PY - 2022/3/10

Y1 - 2022/3/10

N2 - Aims: The study aimed to explore additive interactions of CDKAL1 rs7747752 and GUDCA/DCA for GDM risk and whether the interactive effects on the risk of GDM was mediated via increasing lysophosphatidylcholines (LPC) 18:0 and/or saturated fatty acid (SFA) 16:0. Methods: A 1:1 age-matched study nested in a prospective cohort of pregnant women (207 pairs) was organized in Tianjin, China. Additive interactions were used to test interaction effects while mediation analyses and Sobel tests were used to test mediation effects of LPC18:0 and SFA16:0 between copresence of rs7747752 and low GUDCA/DCA, and GDM risk. Results: The CDKAL1 rs7747752 was associated with GDM (P<0.05). The rs7747752 C polymorphism markedly enhanced ORs of low GUDCA from 4.04 (0.72-22.8) to 9.02 (1.63-49.7) and low DCA from 1.67 (0.68-4.11) to 4.24 (1.84-9.76), both with significant additive interactions. Further adjustment for LPC18:0 attenuated the interactive effects of rs7747752 and low DCA, with a significant mediation effect (P=0.003). High SFA16:0 did not mediate the interactive effects of rs7747752 and low DCA/GUDCA on GDM risk. Conclusions: The CDKAL1 rs7747752 C carrier status and low GUDCA/DCA had significant additive interactions on the risk of GDM with the effect from interaction with DCA being partially mediated via increasing LPC18:0.

AB - Aims: The study aimed to explore additive interactions of CDKAL1 rs7747752 and GUDCA/DCA for GDM risk and whether the interactive effects on the risk of GDM was mediated via increasing lysophosphatidylcholines (LPC) 18:0 and/or saturated fatty acid (SFA) 16:0. Methods: A 1:1 age-matched study nested in a prospective cohort of pregnant women (207 pairs) was organized in Tianjin, China. Additive interactions were used to test interaction effects while mediation analyses and Sobel tests were used to test mediation effects of LPC18:0 and SFA16:0 between copresence of rs7747752 and low GUDCA/DCA, and GDM risk. Results: The CDKAL1 rs7747752 was associated with GDM (P<0.05). The rs7747752 C polymorphism markedly enhanced ORs of low GUDCA from 4.04 (0.72-22.8) to 9.02 (1.63-49.7) and low DCA from 1.67 (0.68-4.11) to 4.24 (1.84-9.76), both with significant additive interactions. Further adjustment for LPC18:0 attenuated the interactive effects of rs7747752 and low DCA, with a significant mediation effect (P=0.003). High SFA16:0 did not mediate the interactive effects of rs7747752 and low DCA/GUDCA on GDM risk. Conclusions: The CDKAL1 rs7747752 C carrier status and low GUDCA/DCA had significant additive interactions on the risk of GDM with the effect from interaction with DCA being partially mediated via increasing LPC18:0.

UR - http://www.scopus.com/inward/record.url?scp=85127421697&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85127421697&partnerID=8YFLogxK

U2 - 10.3389/fendo.2022.808956

DO - 10.3389/fendo.2022.808956

M3 - Article

C2 - 35360068

AN - SCOPUS:85127421697

SN - 1664-2392

VL - 13

JO - Frontiers in Endocrinology

JF - Frontiers in Endocrinology

M1 - 808956

ER -

The CDKAL1 rs7747752-Bile Acids Interaction Increased Risk of Gestational Diabetes Mellitus: A Nested Case-Control Study

Résumé

Note bibliographique

ASJC Scopus Subject Areas

PubMed: MeSH publication types

ODD de l’ONU

Accès au document

Autres fichiers et liens

Empreinte numérique

Citer