The effects of the ionophore A-23187 on the rat vas deferens

M. W. Warenycia; M. M. Vohra

doi:10.1139/y83-012

The effects of the ionophore A-23187 on the rat vas deferens

M. W. Warenycia, M. M. Vohra

Medicine

Medicine

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Résumé

The calcium ionophore A-23187 induced spontaneous, rhythmic contractions in the rat isolated vas deferens in a concentration-dependent manner. Contractions were blocked by phentolamine and were abolished following pretreatment with reserpine. In tissues preloaded with [³H]noradrenaline, A-23187 (10 μM) caused a time-dependent increase in the release of tritium. The findings suggest that A-23187-induced contractions in the rat vas deferens are secondary by X-537A (another calcium ionophore) described earlier by other investigators.

Langue d'origine	English
Pages (de-à)	97-101
Nombre de pages	5
Journal	Canadian Journal of Physiology and Pharmacology
Volume	61
Numéro de publication	1
DOI	https://doi.org/10.1139/y83-012
Statut de publication	Published - 1983

ASJC Scopus Subject Areas

Physiology
Pharmacology
Physiology (medical)

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10.1139/y83-012

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abstract = "The calcium ionophore A-23187 induced spontaneous, rhythmic contractions in the rat isolated vas deferens in a concentration-dependent manner. Contractions were blocked by phentolamine and were abolished following pretreatment with reserpine. In tissues preloaded with [3H]noradrenaline, A-23187 (10 μM) caused a time-dependent increase in the release of tritium. The findings suggest that A-23187-induced contractions in the rat vas deferens are secondary by X-537A (another calcium ionophore) described earlier by other investigators.",

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AB - The calcium ionophore A-23187 induced spontaneous, rhythmic contractions in the rat isolated vas deferens in a concentration-dependent manner. Contractions were blocked by phentolamine and were abolished following pretreatment with reserpine. In tissues preloaded with [3H]noradrenaline, A-23187 (10 μM) caused a time-dependent increase in the release of tritium. The findings suggest that A-23187-induced contractions in the rat vas deferens are secondary by X-537A (another calcium ionophore) described earlier by other investigators.

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The effects of the ionophore A-23187 on the rat vas deferens

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