Résumé
Crohn’s disease (CD), a form of inflammatory bowel disease (IBD), is thought to arise from a complex interaction of genetics, the gut microbiome, and environmental factors, such as diet. There is clear evidence that dietary intervention is successful in the treatment of CD—exclusive enteral nutrition (EEN) is able to induce remission in up to 80% of CD patients. While the mechanism of action of EEN is not clear, EEN is known to cause profound changes in the gut microbiome. Understanding how EEN modifies the gut microbiome to induce remission could provide insight into CD etiopathogenesis and aid the development of microbiome-targeted interventions to guide ongoing dietary therapy to sustain remission. This review includes current literature on changes in composition and function of the gut microbiome associated with EEN treatment in CD patients.
| Langue d'origine | English |
|---|---|
| Numéro d'article | 447 |
| Journal | Nutrients |
| Volume | 9 |
| Numéro de publication | 5 |
| DOI | |
| Statut de publication | Published - mai 2017 |
Note bibliographique
Funding Information:Johan Van Limbergen was supported by a NASPGHAN/CCFA Young Investigator Development award (2013–2015), a Nova Scotia Health Research Foundation (NSHRF) establishment award (2015–2017), a Future Leaders in Inflammatory Bowel Disease (FLIBD) Program grant (2015–2016), a Dalhousie Medical Research Foundation (DMRF) equipment grant (2015–2016), a donation from the MacLeod family, an IWK Health Centre Research Associateship grant (J.M.-C.) and a Canadian Institutes of Health Research (CIHR)-CAG-CCC New Investigator Award (2015–2020: 201412XGP-340307-205026) and a Canadian Foundation of Innovation John R. Evans Leadership fund (#35235).
Publisher Copyright:
© 2017 by the authors. Licensee MDPI, Basel, Switzerland.
ASJC Scopus Subject Areas
- Food Science
- Nutrition and Dietetics