The inflammatory response in candidal chorioamnionitis

Ian C. Hood, Derek J. Desa, Robin K. Whyte

Résultat de recherche: Articleexamen par les pairs

23 Citations (Scopus)

Résumé

Fetal infection with Candida organisms has not commonly been reported. Umbilical cords and placentas from, 23 cases of chorioaminionitis collected over a nine-year period were examined by electron microscopy and immunoperoxidase staining. Gross features, especially of the umbilical cord, were distinctive and included the pale yellow plaques pathognomonic of candidal funisitis. Histopathologically, the lesions were found to be focal and subamniotic and were often embedden in a "fibrinoid" exudate and surrounded by inflammatory cells. In some cases the exudate and inflammatory cells were deposited in dense bands. Immunoperoxidase staining showed the lesions to contain IgG, IgM, and IgA, which probably originated in dense-staining plasmacytoid and immunoblastic cells in the inflammatory infiltrates. Additional findings in two fetal cases of giant cell pneumonitis suggested that the fetus can mount a brisk inflammatory and immune response to Candida organisms as early as 18 weeks' gestation and that mucosal exposure to this antigen can result in production of IgA by the lung.

Langue d'origineEnglish
Pages (de-à)984-990
Nombre de pages7
JournalHuman Pathology
Volume14
Numéro de publication11
DOI
Statut de publicationPublished - nov. 1983

ASJC Scopus Subject Areas

  • Pathology and Forensic Medicine

PubMed: MeSH publication types

  • Journal Article

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