TY - JOUR
T1 - The role of coronary flow and pressure as determinants of myocardial oxygen consumption in the presence or absence of vasomotor tone
AU - Zborowska Sluis, D. T.
AU - Mildenberger, R. R.
AU - Klassen, G. A.
PY - 1977
Y1 - 1977
N2 - When coronary flow was kept constant and coronary pressure increased by angiotensin or decreased by dipyridamole, myocardial oxygen consumption (MVO2) remained unchanged. When vasomotor tone in dogs was abolished by dipyridamole or was intact, changing coronary flow resulted in a change in MVO2 in the same direction as flow; this change in MVO2 was in part the result of a significant alteration in coronary oxygen extraction. These results suggest that coronary flow, but not coronary pressure, is an important determinant of MVO2 both in the presence or absence of vasomotor tone.
AB - When coronary flow was kept constant and coronary pressure increased by angiotensin or decreased by dipyridamole, myocardial oxygen consumption (MVO2) remained unchanged. When vasomotor tone in dogs was abolished by dipyridamole or was intact, changing coronary flow resulted in a change in MVO2 in the same direction as flow; this change in MVO2 was in part the result of a significant alteration in coronary oxygen extraction. These results suggest that coronary flow, but not coronary pressure, is an important determinant of MVO2 both in the presence or absence of vasomotor tone.
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U2 - 10.1139/y77-067
DO - 10.1139/y77-067
M3 - Article
C2 - 884605
AN - SCOPUS:0017656843
SN - 0008-4212
VL - 55
SP - 471
EP - 477
JO - Canadian Journal of Physiology and Pharmacology
JF - Canadian Journal of Physiology and Pharmacology
IS - 3
ER -