The Role of Mitochondrial Calcium Signaling in the Pathophysiology of Cancer Cells

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36 Citations (Scopus)

Résumé

The pioneering work of Richard Altman on the presence of mitochondria in cells set in motion a field of research dedicated to uncovering the secrets of the mitochondria. Despite limitations in studying the structure and function of the mitochondria, advances in our understanding of this organelle prompted the development of potential treatments for various diseases, from neurodegenerative conditions to muscular dystrophy and cancer. As the powerhouses of the cell, the mitochondria represent the essence of cellular life and as such, a selective advantage for cancer cells. Much of the function of the mitochondria relies on Ca2+ homeostasis and the presence of effective Ca2+ signaling to maintain the balance between mitochondrial function and dysfunction and subsequently, cell survival. Ca2+ regulates the mitochondrial respiration rate which in turn increases ATP synthesis, but too much Ca2+ can also trigger the mitochondrial apoptosis pathway; however, cancer cells have evolved mechanisms to modulate mitochondrial Ca2+ influx and efflux in order to sustain their metabolic demand and ensure their survival. Therefore, targeting the mitochondrial Ca2+ signaling involved in the bioenergetic and apoptotic pathways could serve as potential approaches to treat cancer patients. This chapter will review the role of Ca2+ signaling in mediating the function of the mitochondria and its involvement in health and disease with special focus on the pathophysiology of cancer.

Langue d'origineEnglish
Titre de la publication principaleAdvances in Experimental Medicine and Biology
Maison d'éditionSpringer New York LLC
Pages747-770
Nombre de pages24
DOI
Statut de publicationPublished - 2020

Séries de publication

PrénomAdvances in Experimental Medicine and Biology
Volume1131
ISSN (imprimé)0065-2598
ISSN (électronique)2214-8019

Note bibliographique

Funding Information:
Acknowledgements AS is supported through the cancer research training program (CRTP) administered by the Beatrice Hunter Cancer Research Institute (BHCRI) and funded by The Canadian Institute of Health Research (CIHR), Terry Fox Research Institute (TFRI), Cancer Care Nova Scotia, Dalhousie Medical Research Foundation (DMRF) and the Canadian Cancer Society Nova Scotia Division.

Funding Information:
AS is supported through the cancer research training program (CRTP) administered by the Beatrice Hunter Cancer Research Institute (BHCRI) and funded by The Canadian Institute of Health Research (CIHR), Terry Fox Research Institute (TFRI), Cancer Care Nova Scotia, Dalhousie Medical Research Foundation (DMRF) and the Canadian Cancer Society Nova Scotia Division.

Publisher Copyright:
© Springer Nature Switzerland AG 2020.

ASJC Scopus Subject Areas

  • General Biochemistry,Genetics and Molecular Biology

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