The role of proton pump inhibitors on early mycophenolic acid exposure in kidney transplantation: Evidence from the CLEAR study

Bryce A. Kiberd, Michelle Wrobel, Raymond Dandavino, Paul Keown, Sita Gourishankar

Résultat de recherche: Articleexamen par les pairs

21 Citations (Scopus)

Résumé

Introduction: Proton pump inhibitors (PPIs) are often prescribed posttransplantation to prevent gastrointestinal complications. A series of recent studies have reported a relationship between PPI comedication and decreased mycophenolic acid (MPA) exposure. The objective of this subanalysis of the CLEAR data set was to determine the impact of PPI therapy on full MPA area under the curve exposures at Day 5 post kidney transplant. Material and methods: Patients were randomized to receive either intensified dosing of mycophenolate mofetil (1.5 g twice daily on Days 1-5, then 1.0 g twice daily, n = 68) or standard dosing (1.0 g twice daily, n = 67). All recipients received tacrolimus and prednisone. Results: In the modified intention-to-treat population, 57.9% of patients (73 of 126) received PPI therapy. The most frequently administered therapies were pantoprazole and omeprazole. There was no significant difference in mean MPA area under the curve at Day 5 for patients receiving PPI therapy as compared with those not receiving PPI therapy (51.3 versus 55.8 mg.h/L, P = 0.265). However, the MPA concentration-time curve analysis demonstrated a significant decrease in MPA concentrations at 2 hours and 12 hours postdose in patients receiving PPI therapy (P = 0.0009 and P = 0.034). No significant differences were identified in the 3-g arm specifically. In the multivariate model, only serum creatinine and albumin significantly predicted MPA area under the curve less than 30 mg.h/L at Day 5. Discussion and conclusion: PPI therapy in combination with mycophenolate mofetil does not appear to have a significant impact on full MPA exposure. Because MPA pharmacokinetics were not significantly impacted when a 3-g, 5-day loading dose of mycophenolate mofetil was used in combination with PPI therapy, this strategy may be required for adequate MPA exposure whether or not a patient receives PPI comedication.

Langue d'origineEnglish
Pages (de-à)120-123
Nombre de pages4
JournalTherapeutic Drug Monitoring
Volume33
Numéro de publication1
DOI
Statut de publicationPublished - févr. 2011
Publié à l'externeOui

ASJC Scopus Subject Areas

  • Pharmacology
  • Pharmacology (medical)

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