Résumé
The entry of canine distemper virus (CDV) is a multistep process that involves the attachment of CDV hemagglutinin (H) to its cellular receptor, followed by fusion between virus and cell membranes. Our laboratory recently identified PVRL4 (nectin-4) to be the epithelial receptor for measles and canine distemper viruses. In this study, we demonstrate that the V domain of PVRL4 is critical for CDV entry and virus cell-to-cell spread. Furthermore, four key amino acid residues within the V domain of dog PVRL4 and two within the CDV hemagglutinin were shown to be essential for receptor-mediated virus entry.
| Langue d'origine | English |
|---|---|
| Pages (de-à) | 109-117 |
| Nombre de pages | 9 |
| Journal | Virology |
| Volume | 454-455 |
| Numéro de publication | 1 |
| DOI | |
| Statut de publication | Published - avr. 2014 |
Note bibliographique
Funding Information:We would like to thank Veronika von Messling and Craig McCormick, for reagents used to complete this study and Gary Sisson for expert technical assistance. This work was supported by grants from the Canadian Institute for Health Research ( MOP-114949 ) and the Canadian Breast Cancer Foundation – Atlantic Region . C.D.R. is a Canada Research Chair (Tier I) in Vaccinology and Viral Therapeutics and received an equipment grant from the Canadian Foundation for Innovation. R.S.N. was supported by a CIHR Banting Postdoctoral Fellowship .
ASJC Scopus Subject Areas
- Virology
ODD de l’ONU
Cette action contribue à la réalisation des objectifs de développement durable suivants
