Thy-1: More than a mouse pan-T cell marker

S. M.Mansour Haeryfar, David W. Hoskin

Résultat de recherche: Short surveyexamen par les pairs

140 Citations (Scopus)

Résumé

Thy-1 (CD90) is a small GPI-anchored protein that is particularly abundant on the surface of mouse thymocytes and peripheral T cells. T cell proliferation and cytokine synthesis in response to Thy-1 cross-linking by specific mAb suggests a role for Thy-1 in mouse T lymphocyte activation. However, a physiological ligand or counterreceptor for murine Thy-1 in the lymphoid compartment has not yet been identified. Thy-1 cross-linking, in the context of strong costimulatory signaling through CD28, results in an activating signal that can at least partially substitute for TCR signaling during mouse T cell activation. Remarkably, Thy-1 cross-linking also results in the potent costimulation of T cells activated through the TCR. This novel dual signaling capacity suggests a possible role for Thy-1 in the maintenance of T cell homeostasis in the absence of TCR triggering, as well as potentiating Ag-induced T cell responses.

Langue d'origineEnglish
Pages (de-à)3581-3588
Nombre de pages8
JournalJournal of Immunology
Volume173
Numéro de publication6
DOI
Statut de publicationPublished - sept. 15 2004

ASJC Scopus Subject Areas

  • Immunology and Allergy
  • Immunology

PubMed: MeSH publication types

  • Journal Article
  • Research Support, Non-U.S. Gov't
  • Review

Empreinte numérique

Plonger dans les sujets de recherche 'Thy-1: More than a mouse pan-T cell marker'. Ensemble, ils forment une empreinte numérique unique.

Citer