Total and functional antibody response to a quadrivalent meningococcal polysaccharide vaccine among children

W. J. King, N. E. MacDonald, G. Wells, J. Huang, U. Allen, F. Chan, W. Ferris, F. Diaz-Mitoma, F. Ashton

Résultat de recherche: Articleexamen par les pairs

63 Citations (Scopus)

Résumé

Objective: To determine total and functional serogroup C antibody response after vaccination with a quadrivalent meningococcal polysaccharide vaccine. Design: Prospective, before and after intervention study. Subjects: Study subjects were between the ages of 0.5 and 19.9 years, and were eligible for a community-wide public health immunization campaign against Neisseria meningitidis serogroup C. Methods: Total and functional antibody response was measured by enzyme-linked immunosorbent assay and bactericidal assay, respectively. Results: One month after vaccination, total capsular polysaccharide antibody significantly increased in all age groups; a significant rise in bactericidal antibody, that correlated with total capsular polysaccharide antibody, was seen in children 18 months of age and older. At 1 year bactericidal antibody titers were maintained but capsular polysaccharide antibody declined substantially in children younger than 5 years. Conclusion: Total capsular polysaccharide antibody concentration appears to be a useful surrogate measure of bactericidal antibody in children 18 months and older. Children who originally received the vaccine at less than 18 months of age should be considered for revaccination if there is a new or continuing risk of disease. Because of the differences in the total and bactericidal antibodies formed, vaccine efficacy trials are required to define which serologic measures are associated with protection.

Langue d'origineEnglish
Pages (de-à)196-202
Nombre de pages7
JournalJournal of Pediatrics
Volume128
Numéro de publication2
DOI
Statut de publicationPublished - 1996
Publié à l'externeOui

Note bibliographique

Funding Information:
Supported by funding from Connaught Laboratories, the Ontario Ministry of Health, and the Research Institute of the Children's Hospital of Eastern Ontario with the exception of the laboratory investigations, which were performed in collaboration with the Bureau of Microbiology, Laboratory Centre for Disease Control, Ottawa, Ontario, Canada.

ASJC Scopus Subject Areas

  • Pediatrics, Perinatology, and Child Health

PubMed: MeSH publication types

  • Comparative Study
  • Journal Article
  • Research Support, Non-U.S. Gov't

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