Transitions in cognitive status in relation to frailty in older adults: A Comparison of three frailty measures

A. Mitnitski, N. Fallah, M. R.H. Rockwood, K. Rockwood

Résultat de recherche: Articleexamen par les pairs

122 Citations (Scopus)

Résumé

Objectives: Cognitive decline is related to frailty. Frailty can be operationalized in different ways, which have an unknown impact on the estimation of risk. Here, we compared 3 frailty measures in relation to cognitive changes and mortality in the Canadian Study of Health and Aging (CSHA). Design: Prospective population-based study, with 5 year follow up. Participants/Setting: 2,305 subjects aged 70+ years. Methods: For each participant, cognitive status was measured by the errors in the Modified Mini-Mental State Examination (3MS) score. Three frailty measures were used: a Frailty Index based on the Comprehensive Geriatric Assessment (FI-CGA) evaluated from 47 potential deficits, a Clinical Frailty Score and the Fried frailty phenotype. Multivariate Poisson regression and multivariate logistic regression were used to examine the association between baseline cognitive errors and frailty and death, respectively, while controlling for possible confounders (age, sex, education, and baseline cognitive status). Results: Changes in cognitive status were strongly associated with baseline cognition and frailty, however defined. In multivariate models adjusted for age, sex and education, each frailty measure was associated with cognitive decline and with mortality. The frailest people (from the highest FI-CGA tertile) rarely showed cognitive improvement or stabilization (1.5%, 95% CI=0.002%-2.8%) compared with non-frail people (from the lowest tertile of the FI-CGA), of whom 27.8% (95% CI=24.5%-31.1%) did not deteriorate. Conclusions: Frail elderly people have an increased risk of cognitive decline. All frailty measures allowed quantification of individual vulnerability and predict both cognitive changes and mortality.

Langue d'origineEnglish
Pages (de-à)863-867
Nombre de pages5
JournalJournal of Nutrition, Health and Aging
Volume15
Numéro de publication10
DOI
Statut de publicationPublished - déc. 2011

Note bibliographique

Funding Information:
Acknowledgments: Professor Rockwood is supported by the Kathryn Allen Weldon Chair in Alzheimer Research at Dalhousie University award from the Fountain Innovation Fund of the Queen Elizabeth II Health Sciences Foundation. Dr. Fallah is supported by a post-doctoral fellowship from the Alzheimer’s Society of Canada. These analyses were supported by CIHR grant MOP-209888.

ASJC Scopus Subject Areas

  • Medicine (miscellaneous)
  • Nutrition and Dietetics
  • Geriatrics and Gerontology

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Citer

Mitnitski, A., Fallah, N., Rockwood, M. R. H., & Rockwood, K. (2011). Transitions in cognitive status in relation to frailty in older adults: A Comparison of three frailty measures. Journal of Nutrition, Health and Aging, 15(10), 863-867. https://doi.org/10.1007/s12603-011-0066-9