TY - JOUR
T1 - Uncinoside A and B, two new antiviral chromone glycosides from Selaginella uncinata
AU - Ma, Ling Yun
AU - Ma, Shuang Cheng
AU - Wei, Feng
AU - Lin, Rui Chao
AU - But, Paul Pui Hay
AU - Lee, Spencer Hon Sun
AU - Lee, Song Fong
PY - 2003/11
Y1 - 2003/11
N2 - Five compounds have been isolated from the dried whole plants of Selaginella uncinata, two of them were new chromone glycosides, 5-hydroxy-2,6,8-trimethylchromone 7-O-β-D-glucopyranoside (uncinoside A) and 5-acetoxyl-2,6,8-trimethylchromone 7-O-β-D-glucopyranoside (uncinoside B). Their structures were elucidated by spectroscopic methods including one- and two-dimensional NMR techniques. The other three compounds were identified as 8-methyl eugenitol, amentoflavone and hinokiflavone. Uncinoside A and B showed potent antiviral activities against respiratory syncytial virus (RSV) with IC50 value of 6.9 and 1.3 μg/ml, moderate antiviral activities against parainfluenza type 3 virus (PIV 3) with IC50 value of 13.8 and 20.8 μg/ml, respectively.
AB - Five compounds have been isolated from the dried whole plants of Selaginella uncinata, two of them were new chromone glycosides, 5-hydroxy-2,6,8-trimethylchromone 7-O-β-D-glucopyranoside (uncinoside A) and 5-acetoxyl-2,6,8-trimethylchromone 7-O-β-D-glucopyranoside (uncinoside B). Their structures were elucidated by spectroscopic methods including one- and two-dimensional NMR techniques. The other three compounds were identified as 8-methyl eugenitol, amentoflavone and hinokiflavone. Uncinoside A and B showed potent antiviral activities against respiratory syncytial virus (RSV) with IC50 value of 6.9 and 1.3 μg/ml, moderate antiviral activities against parainfluenza type 3 virus (PIV 3) with IC50 value of 13.8 and 20.8 μg/ml, respectively.
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U2 - 10.1248/cpb.51.1264
DO - 10.1248/cpb.51.1264
M3 - Article
C2 - 14600370
AN - SCOPUS:2442526739
SN - 0009-2363
VL - 51
SP - 1264
EP - 1267
JO - Chemical and Pharmaceutical Bulletin
JF - Chemical and Pharmaceutical Bulletin
IS - 11
ER -