Résumé
Autophagy is a conserved eukaryotic mechanism that mediates the removal of long-lived cytoplasmic macromolecules and damaged organelles via a lysosomal degradative pathway. Recently, a multitude of studies have reported that viral infections may have complex interconnections with the autophagic process. These observations strongly imply that autophagy has virus-specific roles relating to viral replication, host innate and adaptive immune responses, virus-induced cell death programs, and viral pathogenesis. Autophagy can supply internal membrane structures necessary for viral replication or may prolong cell survival during viral infections and postpone cell death. It can influence the survival of both infected and bystander cells. This process has also been linked to the recognition of viral signature molecules during innate immunity and has been suggested to help rid the cell of infection. This review discusses interactions between different viruses and the autophagy pathway, and surveys the current state of knowledge and emerging themes within this field.
| Langue d'origine | English |
|---|---|
| Pages (de-à) | 1-10 |
| Nombre de pages | 10 |
| Journal | Virology |
| Volume | 402 |
| Numéro de publication | 1 |
| DOI | |
| Statut de publication | Published - juin 2010 |
Note bibliographique
Funding Information:The authors would like to apologize to any investigators whose works were not included during the publication of this work due to space limitation. The authors would also like to thank Dr. Ryan S. Noyce for his critical reading of the manuscript, and Ting-Fen Chin for her technical assistance with Fig. 1 . L.-T. Lin is a recipient of the National CIHR Research Training Program in Hepatitis C (NCRTP-HepC) fellowship. P.W.H. Dawson is a recipient of a Frederick Banting and Charles Best master's award from the Canadian Institutes of Health Research (CIHR).
ASJC Scopus Subject Areas
- Virology
PubMed: MeSH publication types
- Journal Article
- Research Support, Non-U.S. Gov't
- Review