Department of Pharmacology

2021

Observational Study of Qigong as a Complementary Self-Care Practice at a Tertiary-Care Pain Management Unit

Curry, L., Pike, M., Lynch, M., Marcon, D. & Sawynok, J., 2021, In: Evidence-based Complementary and Alternative Medicine. 2021, 6621069.

Research output: Contribution to journal › Article › peer-review

Open Access

1 Citation (Scopus)

2015

Adenosine A1 Receptor-Dependent Antinociception Induced by Inosine in Mice: Pharmacological, Genetic and Biochemical Aspects

Nascimento, F. P., Macedo-Júnior, S. J., Pamplona, F. A., Luiz-Cerutti, M., Córdova, M. M., Constantino, L., Tasca, C. I., Dutra, R. C., Calixto, J. B., Reid, A., Sawynok, J. & Santos, A. R. S., Jun 1 2015, In: Molecular Neurobiology. 51, 3, p. 1368-1378 11 p.

Research output: Contribution to journal › Article › peer-review

37 Citations (Scopus)

2014

Qualitative analysis of a controlled trial of qigong for fibromyalgia: Advancing understanding of an emerging health practice

Sawynok, J. & Lynch, M., Aug 1 2014, In: Journal of Alternative and Complementary Medicine. 20, 8, p. 606-617 12 p.

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

2013

Antinociception by systemically-administered acetaminophen (paracetamol) involves spinal serotonin 5-HT₇ and adenosine A₁ receptors, as well as peripheral adenosine A₁ receptors

Liu, J., Reid, A. R. & Sawynok, J., Mar 1 2013, In: Neuroscience Letters. 536, 1, p. 64-68 5 p.

Research output: Contribution to journal › Article › peer-review

28 Citations (Scopus)

Chaoyi fanhuan qigong and fibromyalgia: Methodological issues and two case reports

Sawynok, J., Hiew, C. & Marcon, D., Apr 1 2013, In: Journal of Alternative and Complementary Medicine. 19, 4, p. 383-386 4 p.

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Extension trial of qigong for fibromyalgia: A quantitative and qualitative study

Sawynok, J., Lynch, M. & Marcon, D., 2013, In: Evidence-based Complementary and Alternative Medicine. 2013, 726062.

Research output: Contribution to journal › Article › peer-review

Open Access

6 Citations (Scopus)

Spinal and peripheral adenosine A₁ receptors contribute to antinociception by tramadol in the formalin test in mice

Sawynok, J., Reid, A. R. & Liu, J., 2013, In: European Journal of Pharmacology. 714, 1-3, p. 373-378 6 p.

Research output: Contribution to journal › Article › peer-review

31 Citations (Scopus)

2012

A randomized controlled trial of qigong for fibromyalgia

Lynch, M., Sawynok, J., Hiew, C. & Marcon, D., Aug 3 2012, In: Arthritis Research and Therapy. 14, 4, R178.

Research output: Contribution to journal › Article › peer-review

Open Access

63 Citations (Scopus)

Caffeine inhibits antinociception by acetaminophen in the formalin test by inhibiting spinal adenosine A ₁ receptors

Sawynok, J. & Reid, A. R., Jan 14 2012, In: European Journal of Pharmacology. 674, 2-3, p. 248-254 7 p.

Research output: Contribution to journal › Article › peer-review

35 Citations (Scopus)

Pain catastrophizing predicts poor response to topical analgesics in patients with neuropathic pain

Mankovsky, T., Lynch, M. E., Clark, A. J., Sawynok, J. & Sullivan, M. J. L., 2012, In: Pain Research and Management. 17, 1, p. 10-14 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

59 Citations (Scopus)

2011

Reduction of formalin-evoked responses and maintenance of peripheral antinociception by morphine against formalin in the spared nerve injury model

Sawynok, J. & Reid, A. R., Apr 25 2011, In: Neuroscience Letters. 494, 2, p. 99-103 5 p.

Research output: Contribution to journal › Article › peer-review

3 Citations (Scopus)

2009

Perisurgical amitriptyline produces a preventive effect on afferent hypersensitivity following spared nerve injury

Arsenault, A. & Sawynok, J., Dec 5 2009, In: Pain. 146, 3, p. 308-314 7 p.

Research output: Contribution to journal › Article › peer-review

27 Citations (Scopus)

2008

Adrenergic regulation of P2X3 and TRPV1 receptors: Differential effects of spared nerve injury

Meisner, J. G., Reid, A. R. & Sawynok, J., Oct 24 2008, In: Neuroscience Letters. 444, 2, p. 172-175 4 p.

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Caffeine reverses antinociception by amitriptyline in wild type mice but not in those lacking adenosine A₁ receptors

Sawynok, J., Reid, A. R. & Fredholm, B. B., Aug 1 2008, In: Neuroscience Letters. 440, 2, p. 181-184 4 p.

Research output: Contribution to journal › Article › peer-review

26 Citations (Scopus)

2007

α₁-Adrenergic Receptors Augment P2X₃ Receptor-Mediated Nociceptive Responses in the Uninjured State

Meisner, J. G., Waldron, J. B. & Sawynok, J., Jul 2007, In: Journal of Pain. 8, 7, p. 556-562 7 p.

Research output: Contribution to journal › Article › peer-review

25 Citations (Scopus)

2006

Pain behaviors produced by capsaicin: Influence of inflammatory mediators and nerve injury

Sawynok, J., Reid, A. & Meisner, J., Feb 2006, In: Journal of Pain. 7, 2, p. 134-141 8 p.

Research output: Contribution to journal › Article › peer-review

33 Citations (Scopus)

2005

Amitriptyline enhances extracellular tissue levels of adenosine in the rat hindpaw and inhibits adenosine uptake

Sawynok, J., Reid, A. R., Xue, J. L. & Parkinson, F. E., Aug 22 2005, In: European Journal of Pharmacology. 518, 2-3, p. 116-122 7 p.

Research output: Contribution to journal › Article › peer-review

29 Citations (Scopus)

Topical 2% amitriptyline and 1% ketamine in neuropathic pain syndromes: A randomized, double-blind, placebo-controlled trial

Lynch, M. E., Clark, A. J., Sawynok, J. & Sullivan, M. J. L., Jul 2005, In: Anesthesiology. 103, 1, p. 140-146 7 p.

Research output: Contribution to journal › Article › peer-review

133 Citations (Scopus)

Topical amitriptyline and ketamine in neuropathic pain syndromes: An open-label study

Lynch, M. E., Clark, A. J., Sawynok, J. & Sullivan, M. J., Oct 2005, In: Journal of Pain. 6, 10, p. 644-649 6 p.

Research output: Contribution to journal › Article › peer-review

124 Citations (Scopus)

2004

Amitriptyline produces multiple influences on the peripheral enhancement of nociception by P2X receptors

Waldron, J. B., Reid, A. R. & Sawynok, J., Sept 24 2004, In: European Journal of Pharmacology. 499, 3, p. 275-283 9 p.

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Glutamate-evoked release of adenosine and regulation of peripheral nociception

Aumeerally, N., Allen, G. & Sawynok, J., 2004, In: Neuroscience. 127, 1, p. 1-11 11 p.

Research output: Contribution to journal › Article › peer-review

24 Citations (Scopus)

2003

A pilot study examining topical amitriptyline, ketamine, and a combination of both in the treatment of neuropathic pain

Lynch, M. E., Clark, A. J. & Sawynok, J., Sept 2003, In: Clinical Journal of Pain. 19, 5, p. 323-328 6 p.

Research output: Contribution to journal › Article › peer-review

107 Citations (Scopus)

Chronic intrathecal cannulas inhibit some and potentiate other behaviors elicited by formalin injection

Sawynok, J. & Reid, A., May 2003, In: Pain. 103, 1-2, p. 7-9 3 p.

Research output: Contribution to journal › Article › peer-review

1 Citation (Scopus)

Intravenous adenosine alleviates neuropathic pain: A double blind placebo controlled crossover trial using an enriched enrolment design

Lynch, M. E., Clark, A. J. & Sawynok, J., May 2003, In: Pain. 103, 1-2, p. 111-117 7 p.

Research output: Contribution to journal › Article › peer-review

65 Citations (Scopus)

Peripheral antihyperalgesic and analgesic actions of ketamine and amitriptyline in a model of mild thermal injury in the rat

Oatway, M., Reid, A. & Sawynok, J., Jul 1 2003, In: Anesthesia and Analgesia. 97, 1, p. 168-173 6 p.

Research output: Contribution to journal › Article › peer-review

59 Citations (Scopus)

Peripheral interactions between dextromethorphan, ketamine and amitriptyline on formalin-evoked behaviors and paw edema in rats

Sawynok, J. & Reid, A., Mar 2003, In: Pain. 102, 1-2, p. 179-186 8 p.

Research output: Contribution to journal › Article › peer-review

34 Citations (Scopus)

Recent findings surrounding topical antidepressants as analgesics and review of existing and emerging topical analgesics

Sawynok, J., Jul 1 2003, In: Advanced Studies in Medicine. 3, 7 A, p. S635-S641

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

2002

Modulation of formalin-induced behaviors and edema by local and systemic administration of dextromethorphan, memantine and ketamine

Sawynok, J. & Reid, A., Aug 23 2002, In: European Journal of Pharmacology. 450, 2, p. 153-162 10 p.

Research output: Contribution to journal › Article › peer-review

53 Citations (Scopus)

Peripheral amitriptyline suppresses formalin-induced Fos expression in the rat spinal cord

Heughan, C. E., Allen, G. V., Chase, T. D. & Sawynok, J., 2002, In: Anesthesia and Analgesia. 94, 2, p. 427-431 5 p.

Research output: Contribution to journal › Article › peer-review

Open Access

25 Citations (Scopus)

The interaction between gabapentin and amitriptyline in the rat formalin test after systemic administration

Heughan, C. E. & Sawynok, J., 2002, In: Anesthesia and Analgesia. 94, 4, p. 975-980 6 p.

Research output: Contribution to journal › Article › peer-review

25 Citations (Scopus)

2001

Antidepressants as analgesics: An introduction

Sawynok, J., 2001, In: Journal of Psychiatry and Neuroscience. 26, 1, p. 20 1 p.

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Antidepressants as analgesics: An overview of central and peripheral mechanisms of action

Sawynok, J., Esser, M. J. & Reid, A. R., 2001, In: Journal of Psychiatry and Neuroscience. 26, 1, p. 21-29 9 p.

Research output: Contribution to journal › Article › peer-review

204 Citations (Scopus)

Chronic administration of amitriptyline and caffeine in a rat model of neuropathic pain: Multiple interactions

Esser, M. J., Chase, T., Allen, G. V. & Sawynok, J., Nov 2 2001, In: European Journal of Pharmacology. 430, 2-3, p. 211-218 8 p.

Research output: Contribution to journal › Article › peer-review

63 Citations (Scopus)

Involvement of primary sensory afferents, postganglionic sympathetic nerves and mast cells in the formalin-evoked peripheral release of adenosine

Liu, X. J., White, T. D. & Sawynok, J., Oct 10 2001, In: European Journal of Pharmacology. 429, 1-3, p. 147-155 9 p.

Research output: Contribution to journal › Article › peer-review

18 Citations (Scopus)

2000

Caffeine blockade of the thermal antihyperalgesic effect of acute amitriptyline in a rat model of neuropathic pain

Esser, M. J. & Sawynok, J., Jul 7 2000, In: European Journal of Pharmacology. 399, 2-3, p. 131-139 9 p.

Research output: Contribution to journal › Article › peer-review

81 Citations (Scopus)

Involvement of mast cells, sensory afferents and sympathetic mechanisms in paw oedema induced by adenosine A₁ and A(2B/3) receptor agonists

Sawynok, J., Reid, A. & Liu, X. J., Apr 21 2000, In: European Journal of Pharmacology. 395, 1, p. 47-50 4 p.

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Potentiation of formalin-evoked adenosine release by an adenosine kinase inhibitor and an adenosine deaminase inhibitor in the rat hind paw: A microdialysis study

Liu, X. J., White, T. D. & Sawynok, J., Nov 17 2000, In: European Journal of Pharmacology. 408, 2, p. 143-152 10 p.

Research output: Contribution to journal › Article › peer-review

27 Citations (Scopus)

1999

Acute amitriptyline in a rat model of neuropathic pain: Differential symptom and route effects

Esser, M. J. & Sawynok, J., Apr 1 1999, In: Pain. 80, 3, p. 643-653 11 p.

Research output: Contribution to journal › Article › peer-review

143 Citations (Scopus)

Acute paw oedema induced by local injection of adenosine A₁, A₂ and A₃ receptor agonists

Sawynok, J., Reid, A. & Liu, X. J., Dec 15 1999, In: European Journal of Pharmacology. 386, 2-3, p. 253-261 9 p.

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Antinociceptive and anti-inflammatory properties of an adenosine kinase inhibitor and an adenosine deaminase inhibitor

Poon, A. & Sawynok, J., Nov 19 1999, In: European Journal of Pharmacology. 384, 2-3, p. 123-138 16 p.

Research output: Contribution to journal › Article › peer-review

51 Citations (Scopus)

Peripheral antinociceptive action of amitriptyline in the rat formalin test: Involvement of adenosine

Sawynok, J., Reid, A. R. & Esser, M. J., Mar 1 1999, In: Pain. 80, 1-2, p. 45-55 11 p.

Research output: Contribution to journal › Article › peer-review

135 Citations (Scopus)

Peripheral antinociceptive actions of desipramine and fluoxetine in an inflammatory and neuropathic pain test in the rat

Sawynok, J., Esser, M. J. & Reid, A. R., Aug 1 1999, In: Pain. 82, 2, p. 149-158 10 p.

Research output: Contribution to journal › Article › peer-review

126 Citations (Scopus)

1998

Adenosine receptor activation and nociception

Sawynok, J., Apr 17 1998, In: European Journal of Pharmacology. 347, 1, p. 1-11 11 p.

Research output: Contribution to journal › Article › peer-review

444 Citations (Scopus)

Antinociception by adenosine analogs and inhibitors of adenosine metabolism in an inflammatory thermal hyperalgesia model in the rat

Poon, A. & Sawynok, J., Jan 1998, In: Pain. 74, 2-3, p. 235-245 11 p.

Research output: Contribution to journal › Article › peer-review

122 Citations (Scopus)

Peripheral antinociceptive effect of an adenosine kinase inhibitor, with augmentation by an adenosine deaminase inhibitor, in the rat formalin test

Sawynok, J., Reid, A. & Poon, A., Jan 1998, In: Pain. 74, 1, p. 75-81 7 p.

Research output: Contribution to journal › Article › peer-review

55 Citations (Scopus)

1997

Adenosine A₃ receptor activation produces nociceptive behaviour and edema by release of histamine and 5-hydroxytryptamine

Sawynok, J., Zarrindast, M. R., Reid, A. R. & Doak, G. J., Aug 20 1997, In: European Journal of Pharmacology. 333, 1, p. 1-7 7 p.

Research output: Contribution to journal › Article › peer-review

63 Citations (Scopus)

Formalin-induced nocicept1ve behavior and edema: Involvement of multiple peripheral 5-hydroxytryptamine receptor subtypes

Doak, G. J. & Sawynok, J., Jul 28 1997, In: Neuroscience. 80, 3, p. 939-949 11 p.

Research output: Contribution to journal › Article › peer-review

126 Citations (Scopus)

Substance P releases and augments the morphine-evoked release of adenosine from spinal cord

Cahill, C. M., White, T. D. & Sawynok, J., Jun 20 1997, In: Brain Research. 760, 1-2, p. 294-297 4 p.

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

1996

Adenosine kinase inhibitors augment release of adenosine from spinal cord slices

Golembiowska, K., White, T. D. & Sawynok, J., Jun 27 1996, In: European Journal of Pharmacology. 307, 2, p. 157-162 6 p.

Research output: Contribution to journal › Article › peer-review

54 Citations (Scopus)

Caffeine: Biochemistry, pharmacology, and adjuvant effects

Sawynok, J., 1996, In: International Congress and Symposium Series - Royal Society of Medicine. 218, p. 35-42 8 p.

Research output: Contribution to journal › Article › peer-review

Department of Pharmacology

Research output

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