Substance P releases and augments the morphine-evoked release of adenosine from spinal cord

Catherine M. Cahill; Thomas D. White; Jana Sawynok

doi:10.1016/S0006-8993(97)00473-3

Substance P releases and augments the morphine-evoked release of adenosine from spinal cord

Catherine M. Cahill, Thomas D. White, Jana Sawynok

Medicine

Research output: Contribution to journal › Article › peer-review

9 Citations (Scopus)

Abstract

The effects of substance P on the morphine-evoked release of adenosine were examined. Substance P alone produced a multiphasic effect on release of adenosine, with release occurring at low nanomolar concentrations and at a micromolar concentration, but not at intermediate concentrations. An inactive dose of substance P augmented the morphine-evoked release of adenosine at a nanomolar concentration of morphine. Release of adenosine by substance P alone (1 nM) or substance P/morphine (100 nM/10 nM) was Ca²⁺- dependent and originated from capsaicin-sensitive nerve terminals.

Original language	English
Pages (from-to)	294-297
Number of pages	4
Journal	Brain Research
Volume	760
Issue number	1-2
DOIs	https://doi.org/10.1016/S0006-8993(97)00473-3
Publication status	Published - Jun 20 1997

Bibliographical note

Funding Information:
This work was supported by the Medical Research Council of Canada.

ASJC Scopus Subject Areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/S0006-8993(97)00473-3

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abstract = "The effects of substance P on the morphine-evoked release of adenosine were examined. Substance P alone produced a multiphasic effect on release of adenosine, with release occurring at low nanomolar concentrations and at a micromolar concentration, but not at intermediate concentrations. An inactive dose of substance P augmented the morphine-evoked release of adenosine at a nanomolar concentration of morphine. Release of adenosine by substance P alone (1 nM) or substance P/morphine (100 nM/10 nM) was Ca2+- dependent and originated from capsaicin-sensitive nerve terminals.",

author = "Cahill, {Catherine M.} and White, {Thomas D.} and Jana Sawynok",

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AU - White, Thomas D.

AU - Sawynok, Jana

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PY - 1997/6/20

Y1 - 1997/6/20

N2 - The effects of substance P on the morphine-evoked release of adenosine were examined. Substance P alone produced a multiphasic effect on release of adenosine, with release occurring at low nanomolar concentrations and at a micromolar concentration, but not at intermediate concentrations. An inactive dose of substance P augmented the morphine-evoked release of adenosine at a nanomolar concentration of morphine. Release of adenosine by substance P alone (1 nM) or substance P/morphine (100 nM/10 nM) was Ca2+- dependent and originated from capsaicin-sensitive nerve terminals.

AB - The effects of substance P on the morphine-evoked release of adenosine were examined. Substance P alone produced a multiphasic effect on release of adenosine, with release occurring at low nanomolar concentrations and at a micromolar concentration, but not at intermediate concentrations. An inactive dose of substance P augmented the morphine-evoked release of adenosine at a nanomolar concentration of morphine. Release of adenosine by substance P alone (1 nM) or substance P/morphine (100 nM/10 nM) was Ca2+- dependent and originated from capsaicin-sensitive nerve terminals.

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Substance P releases and augments the morphine-evoked release of adenosine from spinal cord

Abstract

Bibliographical note

ASJC Scopus Subject Areas

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