Substance P releases and augments the morphine-evoked release of adenosine from spinal cord

Catherine M. Cahill; Thomas D. White; Jana Sawynok

doi:10.1016/S0006-8993(97)00473-3

Substance P releases and augments the morphine-evoked release of adenosine from spinal cord

Catherine M. Cahill, Thomas D. White, Jana Sawynok

Medicine

Producción científica: Contribución a una revista › Artículo › revisión exhaustiva

9 Citas (Scopus)

Resumen

The effects of substance P on the morphine-evoked release of adenosine were examined. Substance P alone produced a multiphasic effect on release of adenosine, with release occurring at low nanomolar concentrations and at a micromolar concentration, but not at intermediate concentrations. An inactive dose of substance P augmented the morphine-evoked release of adenosine at a nanomolar concentration of morphine. Release of adenosine by substance P alone (1 nM) or substance P/morphine (100 nM/10 nM) was Ca²⁺- dependent and originated from capsaicin-sensitive nerve terminals.

Idioma original	English
Páginas (desde-hasta)	294-297
Número de páginas	4
Publicación	Brain Research
Volumen	760
N.º	1-2
DOI	https://doi.org/10.1016/S0006-8993(97)00473-3
Estado	Published - jun. 20 1997

Nota bibliográfica

Funding Information:
This work was supported by the Medical Research Council of Canada.

ASJC Scopus Subject Areas

General Neuroscience
Molecular Biology
Clinical Neurology
Developmental Biology

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10.1016/S0006-8993(97)00473-3

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title = "Substance P releases and augments the morphine-evoked release of adenosine from spinal cord",

abstract = "The effects of substance P on the morphine-evoked release of adenosine were examined. Substance P alone produced a multiphasic effect on release of adenosine, with release occurring at low nanomolar concentrations and at a micromolar concentration, but not at intermediate concentrations. An inactive dose of substance P augmented the morphine-evoked release of adenosine at a nanomolar concentration of morphine. Release of adenosine by substance P alone (1 nM) or substance P/morphine (100 nM/10 nM) was Ca2+- dependent and originated from capsaicin-sensitive nerve terminals.",

author = "Cahill, {Catherine M.} and White, {Thomas D.} and Jana Sawynok",

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AU - White, Thomas D.

AU - Sawynok, Jana

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PY - 1997/6/20

Y1 - 1997/6/20

N2 - The effects of substance P on the morphine-evoked release of adenosine were examined. Substance P alone produced a multiphasic effect on release of adenosine, with release occurring at low nanomolar concentrations and at a micromolar concentration, but not at intermediate concentrations. An inactive dose of substance P augmented the morphine-evoked release of adenosine at a nanomolar concentration of morphine. Release of adenosine by substance P alone (1 nM) or substance P/morphine (100 nM/10 nM) was Ca2+- dependent and originated from capsaicin-sensitive nerve terminals.

AB - The effects of substance P on the morphine-evoked release of adenosine were examined. Substance P alone produced a multiphasic effect on release of adenosine, with release occurring at low nanomolar concentrations and at a micromolar concentration, but not at intermediate concentrations. An inactive dose of substance P augmented the morphine-evoked release of adenosine at a nanomolar concentration of morphine. Release of adenosine by substance P alone (1 nM) or substance P/morphine (100 nM/10 nM) was Ca2+- dependent and originated from capsaicin-sensitive nerve terminals.

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Substance P releases and augments the morphine-evoked release of adenosine from spinal cord

Resumen

Nota bibliográfica

ASJC Scopus Subject Areas

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