Research output per year
Research output per year
- 1 - 50 out of 91 results
Search results
-
2023
Molecular dynamics study of Cl− permeation through cystic fibrosis transmembrane conductance regulator (CFTR)
Zeng, Z. W., Linsdell, P. & Pomès, R., Feb 2023, In: Cellular and Molecular Life Sciences. 80, 2, 51.Research output: Contribution to journal › Article › peer-review
Open Access5 Citations (Scopus) -
2022
Functionally additive fixed positive and negative charges in the CFTR channel pore control anion binding and conductance
Linsdell, P., Irving, C. L. & Cowley, E. A., Mar 1 2022, In: Journal of Biological Chemistry. 298, 3, 101659.Research output: Contribution to journal › Article › peer-review
Open Access1 Citation (Scopus) -
Lysosomal ATP Transporter SLC17A9 Controls Cell Viability via Regulating Cathepsin D
Huang, P., Cao, Q., Xu, M. & Dong, X. P., Mar 1 2022, In: Cells. 11, 5, 887.Research output: Contribution to journal › Article › peer-review
Open Access7 Citations (Scopus) -
Lysosomal potassium channels
Wu, Y., Xu, M., Wang, P., Syeda, A. K. R., Huang, P. & Dong, X. P., Mar 2022, In: Cell Calcium. 102, 102536.Research output: Contribution to journal › Article › peer-review
13 Citations (Scopus) -
2021
Monovalent: Divalent Anion Selectivity in the CFTR Channel Pore
Linsdell, P., Dec 2021, In: Cell Biochemistry and Biophysics. 79, 4, p. 863-871 9 p.Research output: Contribution to journal › Article › peer-review
2 Citations (Scopus) -
On the relationship between anion binding and chloride conductance in the CFTR anion channel
Linsdell, P., Apr 1 2021, In: Biochimica et Biophysica Acta - Biomembranes. 1863, 4, 183558.Research output: Contribution to journal › Article › peer-review
Open Access5 Citations (Scopus) -
Two positively charged amino acid side-chains in the inner vestibule of the CFTR channel pore play analogous roles in controlling anion binding and anion conductance
Linsdell, P., Irving, C. L., Cowley, E. A. & El Hiani, Y., Jun 2021, In: Cellular and Molecular Life Sciences. 78, 12, p. 5213-5223 11 p.Research output: Contribution to journal › Article › peer-review
4 Citations (Scopus) -
2020
A lysosomal K+ channel regulates large particle phagocytosis by facilitating lysosome Ca2+ release
Sun, X., Xu, M., Cao, Q., Huang, P., Zhu, X. & Dong, X. P., Dec 1 2020, In: Scientific Reports. 10, 1, 1038.Research output: Contribution to journal › Article › peer-review
Open Access24 Citations (Scopus) -
Electrostatic Tuning of Anion Attraction from the Cytoplasm to the Pore of the CFTR Chloride Channel
Linsdell, P., Negoda, A., Cowley, E. A. & El Hiani, Y., Mar 1 2020, In: Cell Biochemistry and Biophysics. 78, 1, p. 15-22 8 p.Research output: Contribution to journal › Article › peer-review
2 Citations (Scopus) -
Multiple facets of TRPML1 in autophagy
Huang, P., Xu, M., Wu, Y., Rizvi Syeda, A. K. & Dong, X. P., Jun 2020, In: Cell Calcium. 88, 102196.Research output: Contribution to journal › Article › peer-review
16 Citations (Scopus) -
2019
Contribution of the eighth transmembrane segment to the function of the CFTR chloride channel pore
Negoda, A., Hogan, M. S., Cowley, E. A. & Linsdell, P., Jun 1 2019, In: Cellular and Molecular Life Sciences. 76, 12, p. 2411-2423 13 p.Research output: Contribution to journal › Article › peer-review
15 Citations (Scopus) -
Lysosomal Ca2+ release channel TRPML1 regulates lysosome size by promoting mTORC1 activity
Yang, Y., Xu, M., Zhu, X., Yao, J., Shen, B. & Dong, X. P., Jun 2019, In: European Journal of Cell Biology. 98, 2-4, p. 116-123 8 p.Research output: Contribution to journal › Article › peer-review
13 Citations (Scopus) -
The lysosomal TRPML1 channel regulates triple negative breast cancer development by promoting mTORC1 and purinergic signaling pathways
Xu, M., Almasi, S., Yang, Y., Yan, C., Sterea, A. M., Rizvi Syeda, A. K., Shen, B., Richard Derek, C., Huang, P., Gujar, S., Wang, J., Zong, W. X., Trebak, M., El Hiani, Y. & Dong, X. P., May 2019, In: Cell Calcium. 79, p. 80-88 9 p.Research output: Contribution to journal › Article › peer-review
48 Citations (Scopus) -
VacA generates a protective intracellular reservoir for Helicobacter pylori that is eliminated by activation of the lysosomal calcium channel TRPML1
Capurro, M. I., Greenfield, L. K., Prashar, A., Xia, S., Abdullah, M., Wong, H., Zhong, X. Z., Bertaux-Skeirik, N., Chakrabarti, J., Siddiqui, I., O’Brien, C., Dong, X., Robinson, L., Peek, R. M., Philpott, D. J., Zavros, Y., Helmrath, M. & Jones, N. L., Aug 1 2019, In: Nature Microbiology. 4, 8, p. 1411-1423 13 p.Research output: Contribution to journal › Article › peer-review
93 Citations (Scopus) -
2018
Conformational change of the extracellular parts of the CFTR protein during channel gating
Negoda, A., Cowley, E. A., El Hiani, Y. & Linsdell, P., Aug 1 2018, In: Cellular and Molecular Life Sciences. 75, 16, p. 3027-3038 12 p.Research output: Contribution to journal › Article › peer-review
4 Citations (Scopus) -
2017
Contribution of a leucine residue in the first transmembrane segment to the selectivity filter region in the CFTR chloride channel
Negoda, A., El Hiani, Y., Cowley, E. A. & Linsdell, P., May 1 2017, In: Biochimica et Biophysica Acta - Biomembranes. 1859, 5, p. 1049-1058 10 p.Research output: Contribution to journal › Article › peer-review
Open Access12 Citations (Scopus) -
Inhibition of transient receptor potential channel mucolipin-1 (TRPML1) by lysosomal adenosine involved in severe combined immunodeficiency diseases
Zhong, X. Z., Zou, Y., Sun, X., Dong, G., Cao, Q., Pandey, A., Rainey, J. K., Zhu, X. & Dong, X. P., Feb 24 2017, In: Journal of Biological Chemistry. 292, 8, p. 3445-3455 11 p.Research output: Contribution to journal › Article › peer-review
Open Access25 Citations (Scopus) -
LYZL6, an acidic, bacteriolytic, human sperm-related protein, plays a role in fertilization
Huang, P., Li, W., Yang, Z., Zhang, N., Xu, Y., Bao, J., Jiang, D. & Dong, X., Feb 1 2017, In: PLoS One. 12, 2, e0171452.Research output: Contribution to journal › Article › peer-review
Open Access10 Citations (Scopus) -
Netrin-1 promotes glioma growth by activating NF-κB via UNC5A
Chen, J. Y., He, X. X., Ma, C., Wu, X. M., Wan, X. L., Xing, Z. K., Pei, Q. Q., Dong, X. P., Liu, D. X., Xiong, W. C. & Zhu, X. J., Dec 1 2017, In: Scientific Reports. 7, 1, 5454.Research output: Contribution to journal › Article › peer-review
Open Access29 Citations (Scopus) -
The lysosomal Ca2+ release channel TRPML1 regulates lysosome size by activating calmodulin
Cao, Q., Yang, Y., Zhong, X. Z. & Dong, X. P., May 19 2017, In: Journal of Biological Chemistry. 292, 20, p. 8424-8435 12 p.Research output: Contribution to journal › Article › peer-review
Open Access91 Citations (Scopus) -
2016
Activation of lysosomal P2X4 by ATP transported into lysosomes via VNUT/SLC17A9 using V-ATPase generated voltage gradient as the driving force
Zhong, X. Z., Cao, Q., Sun, X. & Dong, X. P., Aug 1 2016, In: Journal of Physiology. 594, 15, p. 4253-4266 14 p.Research output: Contribution to journal › Article › peer-review
Open Access17 Citations (Scopus) -
Anion conductance selectivity mechanism of the CFTR chloride channel
Linsdell, P., Apr 2016, In: Biochimica et Biophysica Acta - Biomembranes. 1858, 4, p. 740-747 8 p.Research output: Contribution to journal › Article › peer-review
Open Access22 Citations (Scopus) -
Cytoplasmic pathway followed by chloride ions to enter the CFTR channel pore
El Hiani, Y., Negoda, A. & Linsdell, P., May 1 2016, In: Cellular and Molecular Life Sciences. 73, 9, p. 1917-1925 9 p.Research output: Contribution to journal › Article › peer-review
21 Citations (Scopus) -
2015
BK Channels Alleviate Lysosomal Storage Diseases by Providing Positive Feedback Regulation of Lysosomal Ca2+ Release
Cao, Q., Zhong, X. Z., Zou, Y., Zhang, Z., Toro, L. & Dong, X. P., May 26 2015, In: Developmental Cell. 33, 4, p. 427-441 15 p.Research output: Contribution to journal › Article › peer-review
Open Access101 Citations (Scopus) -
Calcium release through P2X4 activates calmodulin to promote endolysosomal membrane fusion
Cao, Q., Zhong, X. Z., Zou, Y., Murrell-Lagnado, R., Zhu, M. X. & Dong, X. P., 2015, In: Journal of Cell Biology. 209, 6, p. 879-894 16 p.Research output: Contribution to journal › Article › peer-review
Open Access100 Citations (Scopus) -
Functional architecture of the cytoplasmic entrance to the cystic fibrosis transmembrane conductance regulator chloride channel pore
El Hiani, Y. & Linsdell, P., Jun 19 2015, In: Journal of Biological Chemistry. 290, 25, p. 15855-15865 11 p.Research output: Contribution to journal › Article › peer-review
Open Access35 Citations (Scopus) -
Interactions between permeant and blocking anions inside the CFTR chloride channel pore
Linsdell, P., Jul 1 2015, In: Biochimica et Biophysica Acta - Biomembranes. 1848, 7, p. 1573-1590 18 p.Research output: Contribution to journal › Article › peer-review
Open Access12 Citations (Scopus) -
Location of a permeant anion binding site in the cystic fibrosis transmembrane conductance regulator chloride channel pore
Rubaiy, H. N. & Linsdell, P., May 1 2015, In: Journal of Physiological Sciences. 65, 3, p. 233-241 9 p.Research output: Contribution to journal › Article › peer-review
Open Access13 Citations (Scopus) -
Lysosome electrophysiology
Zhong, X. Z. & Dong, X. P., 2015, In: Methods in Cell Biology. 126, p. 197-215 19 p.Research output: Contribution to journal › Article › peer-review
8 Citations (Scopus) -
The cystic fibrosis transmembrane conductance regulator is an extracellular chloride sensor
Broadbent, S. D., Ramjeesingh, M., Bear, C. E., Argent, B. E., Linsdell, P. & Gray, M. A., Aug 24 2015, In: Pflugers Archiv European Journal of Physiology. 467, 8, p. 1783-1794 12 p.Research output: Contribution to journal › Article › peer-review
Open Access17 Citations (Scopus) -
2014
Interaction between 2 extracellular loops influences the activity of the cystic fibrosis transmembrane conductance regulator chloride channel
Broadbent, S. D., Wang, W. & Linsdell, P., 2014, In: Biochemistry and Cell Biology. 92, 5, p. 390-396 7 p.Research output: Contribution to journal › Article › peer-review
7 Citations (Scopus) -
Metal bridges illuminate transmembrane domain movements during gating of the cystic fibrosis transmembrane conductance regulator chloride channel
El Hiani, Y. & Linsdell, P., Oct 10 2014, In: Journal of Biological Chemistry. 289, 41, p. 28149-28159 11 p.Research output: Contribution to journal › Article › peer-review
Open Access12 Citations (Scopus) -
P2X4 forms functional ATP-activated cation channels on lysosomal membranes regulated by luminal pH
Huang, P., Zou, Y., Zhong, X. Z., Cao, Q., Zhao, K., Zhu, M. X., Murrell-Lagnado, R. & Dong, X. P., Jun 20 2014, In: Journal of Biological Chemistry. 289, 25, p. 17658-17667 10 p.Research output: Contribution to journal › Article › peer-review
Open Access111 Citations (Scopus) -
Relative contribution of different transmembrane segments to the CFTR chloride channel pore
Wang, W., El Hiani, Y., Rubaiy, H. N. & Linsdell, P., Mar 2014, In: Pflugers Archiv European Journal of Physiology. 466, 3, p. 477-490 14 p.Research output: Contribution to journal › Article › peer-review
30 Citations (Scopus) -
SLC17A9 protein functions as a lysosomal ATP transporter and regulates cell viability
Cao, Q., Zhao, K., Zhong, X. Z., Zou, Y., Yu, H., Huang, P., Xu, T. L. & Dong, X. P., Aug 15 2014, In: Journal of Biological Chemistry. 289, 33, p. 23189-23199 11 p.Research output: Contribution to journal › Article › peer-review
Open Access56 Citations (Scopus) -
State-dependent blocker interactions with the CFTR chloride channel: implications for gating the pore
Linsdell, P., Nov 18 2014, In: Pflugers Archiv European Journal of Physiology. 466, 12, p. 2243-2255 13 p.Research output: Contribution to journal › Article › peer-review
17 Citations (Scopus) -
2013
Intracellular ASIC1a regulates mitochondrial permeability transition-dependent neuronal death
Wang, Y. Z., Zeng, W. Z., Xiao, X., Huang, Y., Song, X. L., Yu, Z., Tang, D., Dong, X. P., Zhu, M. X. & Xu, T. L., Oct 2013, In: Cell Death and Differentiation. 20, 10, p. 1359-1369 11 p.Research output: Contribution to journal › Article › peer-review
Open Access40 Citations (Scopus) -
2012
Conformational change opening the CFTR chloride channel pore coupled to ATP-dependent gating
Wang, W. & Linsdell, P., Mar 2012, In: Biochimica et Biophysica Acta - Biomembranes. 1818, 3, p. 851-860 10 p.Research output: Contribution to journal › Article › peer-review
Open Access18 Citations (Scopus) -
Pseudohalide anions reveal a novel extracellular site for potentiators to increase CFTR function
Li, M. S., Cowley, E. A. & Linsdell, P., Nov 2012, In: British Journal of Pharmacology. 167, 5, p. 1062-1075 14 p.Research output: Contribution to journal › Article › peer-review
9 Citations (Scopus) -
Relative movements of transmembrane regions at the outer mouth of the cystic fibrosis transmembrane conductance regulator channel pore during channel gating
Wang, W. & Linsdell, P., Sept 14 2012, In: Journal of Biological Chemistry. 287, 38, p. 32136-32146 11 p.Research output: Contribution to journal › Article › peer-review
Open Access21 Citations (Scopus) -
Role of the juxtamembrane region of cytoplasmic loop 3 in the gating and conductance of the cystic fibrosis transmembrane conductance regulator chloride channel
El Hiani, Y. & Linsdell, P., May 15 2012, In: Biochemistry. 51, 19, p. 3971-3981 11 p.Research output: Contribution to journal › Article › peer-review
Open Access9 Citations (Scopus) -
Tuning of CFTR chloride channel function by location of positive charges within the pore
El Hiani, Y. & Linsdell, P., Oct 17 2012, In: Biophysical Journal. 103, 8, p. 1719-1726 8 p.Research output: Contribution to journal › Article › peer-review
Open Access24 Citations (Scopus) -
2011
Alignment of transmembrane regions in the cystic fibrosis transmembrane conductance regulator chloride channel pore
Wang, W., Hiani, Y. E. & Linsdell, P., Aug 2011, In: Journal of General Physiology. 138, 2, p. 165-178 14 p.Research output: Contribution to journal › Article › peer-review
Open Access52 Citations (Scopus) -
Functional arrangement of the 12th transmembrane region in the CFTR chloride channel pore based on functional investigation of a cysteine-less CFTR variant
Qian, F., El Hiani, Y. & Linsdell, P., Oct 2011, In: Pflugers Archiv European Journal of Physiology. 462, 4, p. 559-571 13 p.Research output: Contribution to journal › Article › peer-review
40 Citations (Scopus) -
Functional differences in pore properties between wild-type and cysteine-less forms of the CFTR chloride channel
Holstead, R. G., Li, M. S. & Linsdell, P., Oct 2011, In: Journal of Membrane Biology. 243, 1-3, p. 15-23 9 p.Research output: Contribution to journal › Article › peer-review
17 Citations (Scopus) -
Regulation of CFTR chloride channel macroscopic conductance by extracellular bicarbonate
Li, M. S., Holstead, R. G., Wang, W. & Linsdell, P., Jan 2011, In: American Journal of Physiology - Cell Physiology. 300, 1, p. C65-C74Research output: Contribution to journal › Article › peer-review
15 Citations (Scopus) -
2010
Changes in accessibility of cytoplasmic substances to the pore associated with activation of the cystic fibrosis transmembrane conductance regulator chloride channel
El Hiani, Y. & Linsdell, P., Oct 15 2010, In: Journal of Biological Chemistry. 285, 42, p. 32126-32140 15 p.Research output: Contribution to journal › Article › peer-review
Open Access51 Citations (Scopus) -
The intermediate conductance Ca 2+-activated K + channel inhibitor TRAM-34 stimulates proliferation of breast cancer cells via activation of oestrogen receptors
Roy, J. W., Cowley, E. A., Blay, J. & Linsdell, P., Feb 2010, In: British Journal of Pharmacology. 159, 3, p. 650-658 9 p.Research output: Contribution to journal › Article › peer-review
13 Citations (Scopus) -
2009
Cysteine-independent inhibition of the CFTR chloride channel by the cysteine-reactive reagent sodium (2-sulphonatoethyl) methanethiosulphonate
Li, M. S., Demsey, A. F. A., Qi, J. & Linsdell, P., 2009, In: British Journal of Pharmacology. 157, 6, p. 1065-1071 7 p.Research output: Contribution to journal › Article › peer-review
Open Access23 Citations (Scopus) -
Evidence that extracellular anions interact with a site outside the CFTR chloride channel pore to modify channel properties
Zhou, J. J. & Linsdell, P., May 2009, In: Canadian Journal of Physiology and Pharmacology. 87, 5, p. 387-395 9 p.Research output: Contribution to journal › Article › peer-review
10 Citations (Scopus)