Lysosomal potassium channels

Yi Wu; Mengnan Xu; Pingping Wang; Alia Kazim Rizvi Syeda; Peng Huang; Xian Ping Dong

doi:10.1016/j.ceca.2022.102536

Lysosomal potassium channels

Yi Wu, Mengnan Xu, Pingping Wang, Alia Kazim Rizvi Syeda, Peng Huang, Xian Ping Dong

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

The lysosome is an important membrane-bound acidic organelle that is regarded as the degradative center as well as multifunctional signaling hub. It digests unwanted macromolecules, damaged organelles, microbes, and other materials derived from endocytosis, autophagy, and phagocytosis. To function properly, the ionic homeostasis and membrane potential of the lysosome are strictly regulated by transporters and ion channels. As the most abundant cation inside the cell, potassium ions (K⁺) are vital for lysosomal membrane potential and lysosomal calcium (Ca²⁺) signaling. However, our understanding about how lysosomal K⁺homeostasis is regulated and what are the functions of K⁺in the lysosome is very limited. Currently, two lysosomal K⁺channels have been identified: large-conductance Ca²⁺-activated K⁺channel (BK) and transmembrane Protein 175 (TMEM175). In this review, we summarize recent development in our understanding of K⁺ homeostasis and K⁺channels in the lysosome. We hope to guide the readers into a more in-depth discussion of lysosomal K⁺ channels in lysosomal physiology and human diseases.

Original language	English
Article number	102536
Journal	Cell Calcium
Volume	102
DOIs	https://doi.org/10.1016/j.ceca.2022.102536
Publication status	Published - Mar 2022

Bibliographical note

Funding Information:
This work was supported by Shanghai Municipal Health Commission Foundation grant [ 20204Y0379 ] to Y.W. and CIHR project grant [ PJT-156102 ] to X.D. All authors have read and agreed to the published version of the manuscript. We are grateful to our colleagues for their constructive comments. We apologize to colleagues whose works are not cited due to space limitations.

Publisher Copyright:
© 2022

ASJC Scopus Subject Areas

Physiology
Molecular Biology
Cell Biology

PubMed: MeSH publication types

Journal Article
Research Support, Non-U.S. Gov't
Review

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.ceca.2022.102536

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title = "Lysosomal potassium channels",

abstract = "The lysosome is an important membrane-bound acidic organelle that is regarded as the degradative center as well as multifunctional signaling hub. It digests unwanted macromolecules, damaged organelles, microbes, and other materials derived from endocytosis, autophagy, and phagocytosis. To function properly, the ionic homeostasis and membrane potential of the lysosome are strictly regulated by transporters and ion channels. As the most abundant cation inside the cell, potassium ions (K+) are vital for lysosomal membrane potential and lysosomal calcium (Ca2+) signaling. However, our understanding about how lysosomal K+homeostasis is regulated and what are the functions of K+in the lysosome is very limited. Currently, two lysosomal K+channels have been identified: large-conductance Ca2+-activated K+channel (BK) and transmembrane Protein 175 (TMEM175). In this review, we summarize recent development in our understanding of K+ homeostasis and K+channels in the lysosome. We hope to guide the readers into a more in-depth discussion of lysosomal K+ channels in lysosomal physiology and human diseases.",

author = "Yi Wu and Mengnan Xu and Pingping Wang and Syeda, {Alia Kazim Rizvi} and Peng Huang and Dong, {Xian Ping}",

note = "Funding Information: This work was supported by Shanghai Municipal Health Commission Foundation grant [ 20204Y0379 ] to Y.W. and CIHR project grant [ PJT-156102 ] to X.D. All authors have read and agreed to the published version of the manuscript. We are grateful to our colleagues for their constructive comments. We apologize to colleagues whose works are not cited due to space limitations. Publisher Copyright: {\textcopyright} 2022",

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doi = "10.1016/j.ceca.2022.102536",

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AU - Wu, Yi

AU - Xu, Mengnan

AU - Wang, Pingping

AU - Syeda, Alia Kazim Rizvi

AU - Huang, Peng

AU - Dong, Xian Ping

N1 - Funding Information: This work was supported by Shanghai Municipal Health Commission Foundation grant [ 20204Y0379 ] to Y.W. and CIHR project grant [ PJT-156102 ] to X.D. All authors have read and agreed to the published version of the manuscript. We are grateful to our colleagues for their constructive comments. We apologize to colleagues whose works are not cited due to space limitations. Publisher Copyright: © 2022

PY - 2022/3

Y1 - 2022/3

N2 - The lysosome is an important membrane-bound acidic organelle that is regarded as the degradative center as well as multifunctional signaling hub. It digests unwanted macromolecules, damaged organelles, microbes, and other materials derived from endocytosis, autophagy, and phagocytosis. To function properly, the ionic homeostasis and membrane potential of the lysosome are strictly regulated by transporters and ion channels. As the most abundant cation inside the cell, potassium ions (K+) are vital for lysosomal membrane potential and lysosomal calcium (Ca2+) signaling. However, our understanding about how lysosomal K+homeostasis is regulated and what are the functions of K+in the lysosome is very limited. Currently, two lysosomal K+channels have been identified: large-conductance Ca2+-activated K+channel (BK) and transmembrane Protein 175 (TMEM175). In this review, we summarize recent development in our understanding of K+ homeostasis and K+channels in the lysosome. We hope to guide the readers into a more in-depth discussion of lysosomal K+ channels in lysosomal physiology and human diseases.

AB - The lysosome is an important membrane-bound acidic organelle that is regarded as the degradative center as well as multifunctional signaling hub. It digests unwanted macromolecules, damaged organelles, microbes, and other materials derived from endocytosis, autophagy, and phagocytosis. To function properly, the ionic homeostasis and membrane potential of the lysosome are strictly regulated by transporters and ion channels. As the most abundant cation inside the cell, potassium ions (K+) are vital for lysosomal membrane potential and lysosomal calcium (Ca2+) signaling. However, our understanding about how lysosomal K+homeostasis is regulated and what are the functions of K+in the lysosome is very limited. Currently, two lysosomal K+channels have been identified: large-conductance Ca2+-activated K+channel (BK) and transmembrane Protein 175 (TMEM175). In this review, we summarize recent development in our understanding of K+ homeostasis and K+channels in the lysosome. We hope to guide the readers into a more in-depth discussion of lysosomal K+ channels in lysosomal physiology and human diseases.

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Lysosomal potassium channels

Abstract

Bibliographical note

ASJC Scopus Subject Areas

PubMed: MeSH publication types

UN SDGs

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