Lysosomal potassium channels

Yi Wu, Mengnan Xu, Pingping Wang, Alia Kazim Rizvi Syeda, Peng Huang, Xian Ping Dong

Producción científica: Contribución a una revistaArtículorevisión exhaustiva

14 Citas (Scopus)

Resumen

The lysosome is an important membrane-bound acidic organelle that is regarded as the degradative center as well as multifunctional signaling hub. It digests unwanted macromolecules, damaged organelles, microbes, and other materials derived from endocytosis, autophagy, and phagocytosis. To function properly, the ionic homeostasis and membrane potential of the lysosome are strictly regulated by transporters and ion channels. As the most abundant cation inside the cell, potassium ions (K+) are vital for lysosomal membrane potential and lysosomal calcium (Ca2+) signaling. However, our understanding about how lysosomal K+homeostasis is regulated and what are the functions of K+in the lysosome is very limited. Currently, two lysosomal K+channels have been identified: large-conductance Ca2+-activated K+channel (BK) and transmembrane Protein 175 (TMEM175). In this review, we summarize recent development in our understanding of K+ homeostasis and K+channels in the lysosome. We hope to guide the readers into a more in-depth discussion of lysosomal K+ channels in lysosomal physiology and human diseases.

Idioma originalEnglish
Número de artículo102536
PublicaciónCell Calcium
Volumen102
DOI
EstadoPublished - mar. 2022

Nota bibliográfica

Funding Information:
This work was supported by Shanghai Municipal Health Commission Foundation grant [ 20204Y0379 ] to Y.W. and CIHR project grant [ PJT-156102 ] to X.D. All authors have read and agreed to the published version of the manuscript. We are grateful to our colleagues for their constructive comments. We apologize to colleagues whose works are not cited due to space limitations.

Publisher Copyright:
© 2022

ASJC Scopus Subject Areas

  • Physiology
  • Molecular Biology
  • Cell Biology

PubMed: MeSH publication types

  • Journal Article
  • Research Support, Non-U.S. Gov't
  • Review

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