Research output per year
Research output per year
- 1 - 50 out of 125 results
Search results
-
2013
Optimization of human nasal epithelium primary culture conditions for optimal proton oligopeptide and organic cation transporters expression in vitro
Shao, D., Massoud, E., Clarke, D., Cowley, E., Renton, K. & Agu, R. U., Jan 30 2013, In: International Journal of Pharmaceutics. 441, 1-2, p. 334-342 9 p.Research output: Contribution to journal › Article › peer-review
5 Citations (Scopus) -
2011
Differential expression of organic cation transporters in normal and polyps human nasal epithelium: Implications for in vitro drug delivery studies
Agu, R., MacDonald, C., Cowley, E., Shao, D., Renton, K., Clarke, D. B. & Massoud, E., Mar 15 2011, In: International Journal of Pharmaceutics. 406, 1-2, p. 49-54 6 p.Research output: Contribution to journal › Article › peer-review
16 Citations (Scopus) -
Proton-coupled oligopeptide transporter (POT) family expression in human nasal epithelium and their drug transport potential
Agu, R., Cowley, E., Shao, D., MacDonald, C., Kirkpatrick, D., Renton, K. & Massoud, E., Jun 6 2011, In: Molecular Pharmaceutics. 8, 3, p. 664-672 9 p.Research output: Contribution to journal › Article › peer-review
33 Citations (Scopus) -
2009
Effect of acute inflammatory brain injury on accumulation of morphine and morphine 3- and 6-glucuronide in the human brain
Roberts, D. J., Goralski, K. B., Renton, K. W., Julien, L. C., Webber, A. M., Sleno, L., Volmer, D. A. & Hall, R. I., Oct 2009, In: Critical Care Medicine. 37, 10, p. 2767-2774 8 p.Research output: Contribution to journal › Article › peer-review
26 Citations (Scopus) -
2008
Regulation of drug-metabolizing enzymes and transporters in infection, inflammation, and cancer
Morgan, E. T., Goralski, K. B., Piquette-Miller, M., Renton, K. W., Robertson, G. R., Chaluvadi, M. R., Charles, K. A., Clarke, S. J., Kacevska, M., Liddle, C., Richardson, T. A., Sharma, R. & Sinal, C. J., Feb 2008, In: Drug Metabolism and Disposition. 36, 2, p. 205-216 12 p.Research output: Contribution to journal › Article › peer-review
348 Citations (Scopus) -
2006
Evaluation of Performance Factors Affecting Two Formulations of Cyclosporine in Pediatric Renal Transplant Patients
Acott, P. D., Crocker, J. F. & Renton, K. W., Nov 2006, In: Transplantation Proceedings. 38, 9, p. 2835-2841 7 p.Research output: Contribution to journal › Article › peer-review
5 Citations (Scopus) -
Pamidronate distribution in pediatric renal and rheumatologic patients
Acott, P. D., Wong, J. A., Crocker, J. F. S., Lang, B., O'Regan, P. & Renton, K. W., Dec 2006, In: European Journal of Clinical Pharmacology. 62, 12, p. 1013-1019 7 p.Research output: Contribution to journal › Article › peer-review
2 Citations (Scopus) -
The regulation of cytochrome P450 2E1 during LPS-induced inflammation in the rat
Abdulla, D., Goralski, K. B. & Renton, K. W., Oct 1 2006, In: Toxicology and Applied Pharmacology. 216, 1, p. 1-10 10 p.Research output: Contribution to journal › Article › peer-review
20 Citations (Scopus) -
2005
Paradoxical cyclosporine A requirements in pediatric renal transplants receiving high-dose steroids
Hardy, K. W., Crocker, J. F. S., McLellan, H., Goralski, K. B., Renton, K. W. & Acott, P. D., Feb 2005, In: Journal of Clinical Pharmacology. 45, 2, p. 161-167 7 p.Research output: Contribution to journal › Article › peer-review
2 Citations (Scopus) -
Regulation of drug metabolism and disposition during inflammation and infection
Renton, K. W., Dec 2005, In: Expert Opinion on Drug Metabolism and Toxicology. 1, 4, p. 629-640 12 p.Research output: Contribution to journal › Review article › peer-review
143 Citations (Scopus) -
The signal transduction pathways involved in hepatic cytochrome p450 regulation in the rat during a lipopolysaccharide-induced model of central nervous system inflammation
Abdulla, D., Goralski, K. B., Garcia Del Busto Cano, E. & Renton, K. W., Oct 2005, In: Drug Metabolism and Disposition. 33, 10, p. 1521-1531 11 p.Research output: Contribution to journal › Article › peer-review
30 Citations (Scopus) -
Toll-like receptor-4 regulation of hepatic Cyp3a11 metabolism in a mouse model of LPS-induced CNS inflammation
Goralski, K. B., Abdulla, D., Sinal, C. J., Arsenault, A. & Renton, K. W., Sept 2005, In: American Journal of Physiology - Gastrointestinal and Liver Physiology. 289, 3 52-3, p. G434-G443Research output: Contribution to journal › Article › peer-review
34 Citations (Scopus) -
β-Adrenergic receptor modulation of the LPS-mediated depression in CYP1A activity in astrocytes
Abdulla, D. & Renton, K. W., Mar 1 2005, In: Biochemical Pharmacology. 69, 5, p. 741-750 10 p.Research output: Contribution to journal › Article › peer-review
18 Citations (Scopus) -
2004
A comparison of the pharmacokinetics of tacrolimus and microemulsified cyclosporin in paediatric renal transplant recipients
Renton, K. W., Crocker, J. F. S., McLellan, H. & Acott, P. D., Aug 2004, In: European Journal of Clinical Pharmacology. 60, 6, p. 421-426 6 p.Research output: Contribution to journal › Article › peer-review
1 Citation (Scopus) -
Brain inflammation enhances 1-methyl-4-phenylpyridinium-evoked neurotoxicity in rats
Goralski, K. B. & Renton, K. W., May 1 2004, In: Toxicology and Applied Pharmacology. 196, 3, p. 381-389 9 p.Research output: Contribution to journal › Article › peer-review
17 Citations (Scopus) -
Cytochrome P450 regulation and drug biotransformation during inflammation and infection
Renton, K. W., Jun 2004, In: Current Drug Metabolism. 5, 3, p. 235-243 9 p.Research output: Contribution to journal › Review article › peer-review
162 Citations (Scopus) -
Determination of pamidronate in human whole blood and urine by reversed-phase HPLC with fluorescence detection
Wong, J. A., Renton, K. W., Crocker, J. F. S., O'Regan, P. A. & Acott, P. D., Mar 2004, In: Biomedical Chromatography. 18, 2, p. 98-101 4 p.Research output: Contribution to journal › Article › peer-review
33 Citations (Scopus) -
Nitric oxide mediates an LPS-induced depression of cytochrome P450 (CYP1A) activity in astrocytes
Nicholson, T. E., Dibb, S. & Renton, K. W., Dec 17 2004, In: Brain Research. 1029, 2, p. 148-154 7 p.Research output: Contribution to journal › Article › peer-review
13 Citations (Scopus) -
2003
Downregulation of mdr1a expression in the brain and liver during CNS inflammation alters the in vivo disposition of digoxin
Goralski, K. B., Hartmann, G., Piquette-Miller, M. & Renton, K. W., May 2003, In: British Journal of Pharmacology. 139, 1, p. 35-48 14 p.Research output: Contribution to journal › Article › peer-review
113 Citations (Scopus) -
Modulation of hepatic cytochrome P450 during Listeria monocytogenes infection of the brain
Garcia del Busto Cano, E. & Renton, K. W., Sept 1 2003, In: Journal of Pharmaceutical Sciences. 92, 9, p. 1860-1868 9 p.Research output: Contribution to journal › Article › peer-review
17 Citations (Scopus) -
2002
Noradrenergic and Serotonergic Neuroendocrine Responses in Prepubertal, Peripubertal, and Postpubertal Rats Pretreated with Desipramine and Sertraline
Carrey, N. J., Dursun, S., Clements, R., Renton, K., Waschbusch, D. & MacMaster, F. P., Aug 2002, In: Journal of the American Academy of Child and Adolescent Psychiatry. 41, 8, p. 999-1006 8 p.Research output: Contribution to journal › Article › peer-review
21 Citations (Scopus) -
The role of cytokines in the depression of CYP1A activity using cultured astrocytes as an in vitro model of inflammation in the central nervous system
Nicholson, T. E. & Renton, K. W., 2002, In: Drug Metabolism and Disposition. 30, 1, p. 42-46 5 p.Research output: Contribution to journal › Article › peer-review
34 Citations (Scopus) -
2001
Alteration of drug biotransformation and elimination during infection and inflammation
Renton, K. W., 2001, In: Pharmacology and Therapeutics. 92, 2-3, p. 147-163 17 p.Research output: Contribution to journal › Review article › peer-review
176 Citations (Scopus) -
Effect of lipopolysaccharide (LPS)-evoked host defense activation on hepatic microsomal formation and reduction of sulfamethoxazole hydroxylamine in the rat
Cribb, A. E., McQuaid, T. & Renton, K. W., Aug 15 2001, In: Biochemical Pharmacology. 62, 4, p. 457-459 3 p.Research output: Contribution to journal › Article › peer-review
7 Citations (Scopus) -
Role of cytokines in the lipopolysaccharide-evoked depression of cytochrome P450 in the brain and liver
Nicholson, T. E. & Renton, K. W., Dec 15 2001, In: Biochemical Pharmacology. 62, 12, p. 1709-1717 9 p.Research output: Contribution to journal › Article › peer-review
39 Citations (Scopus) -
2000
Hepatic and central nervous system cytochrome P450 are down-regulated during lipopolysaccharide-evoked localized inflammation in brain
Renton, K. W. & Nicholson, T. E., Aug 2000, In: Journal of Pharmacology and Experimental Therapeutics. 294, 2, p. 524-530 7 p.Research output: Contribution to journal › Article › peer-review
72 Citations (Scopus) -
Hepatic drug metabolism and immunostimulation
Renton, K. W., Jan 17 2000, In: Toxicology. 142, 3, p. 173-178 6 p.Research output: Contribution to journal › Article › peer-review
40 Citations (Scopus) -
1999
Impact of diseases on detoxication
Blouin, R. A., Farrell, G. C., Ioannides, C., Renton, K. & Watlington, C. O., 1999, In: Journal of Biochemical and Molecular Toxicology. 13, 3-4, p. 215-218 4 p.Research output: Contribution to journal › Article › peer-review
9 Citations (Scopus) -
Lipopolysaccharide evokes the modulation of brain cytochrome P4501A in the rat
Renton, K. W., Dibb, S. & Levatte, T. L., Sept 18 1999, In: Brain Research. 842, 1, p. 139-147 9 p.Research output: Contribution to journal › Article › peer-review
28 Citations (Scopus) -
Modulation of cytochrome P450 by inflammation in astrocytes
Nicholson, T. E. & Renton, K. W., May 8 1999, In: Brain Research. 827, 1-2, p. 12-18 7 p.Research output: Contribution to journal › Article › peer-review
40 Citations (Scopus) -
1998
Acute allograft rejection following conversion to a new cyclosporine formulation in pediatric renal transplant patients
Crocker, J., Renton, K., Wade, A., McLellan, H. & Acott, P., 1998, In: Transplantation Proceedings. 30, 5, p. 2002-2005 4 p.Research output: Contribution to journal › Article › peer-review
1 Citation (Scopus) -
Cytokine-mediated down-regulation of CYP1A1 in hepa1 cells
Paton, T. E. & Rentom, K. W., Jun 1 1998, In: Biochemical Pharmacology. 55, 11, p. 1791-1796 6 p.Research output: Contribution to journal › Article › peer-review
35 Citations (Scopus) -
Effects of antipyretics on mortality due to influenza B virus in a mouse model of Reye's syndrome
Crocker, J. F. S., Digout, S. C., Lee, S. H., Rozee, K. R., Renton, K., Field, C. A., Acott, P. & Murphy, M. G., 1998, In: Clinical and Investigative Medicine. 21, 4-5, p. 192-202 11 p.Research output: Contribution to journal › Article › peer-review
20 Citations (Scopus) -
1997
Amlodipine inhibits rat microsomal cytochrome P450-mediated drug biotransformation
Drobitch, R. K., Mclellan, R. A. & Renton, K. W., 1997, In: Journal of Pharmaceutical Sciences. 86, 12, p. 1501-1503 3 p.Research output: Contribution to journal › Article › peer-review
5 Citations (Scopus) -
Cytochrome P4501A1 and cytochrome P4501A2 are downregulated at both transcriptional and post-transcriptional levels by conditions resulting in interferon-α/β induction
Delaporte, E. & Renton, K. W., Jan 31 1997, In: Life Sciences. 60, 10, p. 787-796 10 p.Research output: Contribution to journal › Article › peer-review
46 Citations (Scopus) -
1996
Differential effect of pentoxifylline on lipopolysaccharide-induced downregulation of cytochrome P450
Monshouwer, M., McLellan, R. A., Delaporte, E., Witkamp, R. F., Van Miert, A. S. J. P. A. M. & Renton, K. W., Oct 25 1996, In: Biochemical Pharmacology. 52, 8, p. 1195-1200 6 p.Research output: Contribution to journal › Article › peer-review
50 Citations (Scopus) -
Fluoroquinolone antibiotics inhibit cytochrome P450-mediated microsomal drug metabolism in rat and human
Mclellan, R. A., Drobitch, R. K., Monshouwer, M. & Renton, K. W., Oct 1996, In: Drug Metabolism and Disposition. 24, 10, p. 1134-1138 5 p.Research output: Contribution to journal › Article › peer-review
108 Citations (Scopus) -
1995
Inteferon-mediated changes in the expression of CYP1A1 in human b lymphoblastoid (AHH-1 TK+/-) cells
Delaporte, E., Cribb, A. E. & Renton, K. W., 1995, In: Canadian Journal of Physiology and Pharmacology. 73, 12, p. 1692-1697 6 p.Research output: Contribution to journal › Article › peer-review
11 Citations (Scopus) -
Norfloxacin interferes with cyclosporine disposition in pediatric patients undergoing renal transplantation
McLellan, R. A., Drobitch, R. K., McLellan, D. H., Acott, P. D., Crocker, J. F. S. & Renton, K. W., Sept 1995, In: Clinical Pharmacology and Therapeutics. 58, 3, p. 322-327 6 p.Research output: Contribution to journal › Article › peer-review
21 Citations (Scopus) -
The duration of induction and species influences the downregulation of cytochrome P450 by the interferon inducer polyinosinic acid-polycytidylic acid
Anari, M. R., Cribb, A. E. & Renton, K. W., 1995, In: Drug Metabolism and Disposition. 23, 5, p. 536-541 6 p.Research output: Contribution to journal › Article › peer-review
17 Citations (Scopus) -
The role of nitric oxide generation in interferon-evoked cytochrome P450 down-regulation
Hodgson, P. D. & Renton, K. W., Dec 1995, In: International Journal of Immunopharmacology. 17, 12, p. 995-1000 6 p.Research output: Contribution to journal › Article › peer-review
22 Citations (Scopus) -
1994
Acetylator phenotyping: The urinary caffeine metabolite ratio in slow acetylators correlates with a marker of systemic NAT1 activity
Cribb, A. E., Isbrucker, R., Levatte, T., Tsui, B., Gillespie, C. T. & Renton, K. W., Jun 1994, In: Pharmacogenetics. 4, 3, p. 166-170 5 p.Research output: Contribution to journal › Article › peer-review
29 Citations (Scopus) -
Factors involved in the down-regulation of cytochrome P450 during Listeria monocytogenes infection
Armstrong, S. G. & Renton, K. W., Sept 1994, In: International Journal of Immunopharmacology. 16, 9, p. 747-754 8 p.Research output: Contribution to journal › Article › peer-review
14 Citations (Scopus) -
Regulation of cytochrome P-4501A and cytochrome P-4502E induction in the rat during the production of interferon α/β
Cribb, A. E., Delaporte, E., Kim, S. G., Novak, R. F. & Renton, K. W., 1994, In: Journal of Pharmacology and Experimental Therapeutics. 268, 1, p. 487-494 8 p.Research output: Contribution to journal › Article › peer-review
42 Citations (Scopus) -
The interaction of the calcium channel blockers verapamil and nifedipine with cyclosporin A in pediatric renal transplant patients
Crocker, J. F. S., Renton, K. W., Le Vatte, T. L. & Heather McLellan, D., Aug 1994, In: Pediatric Nephrology. 8, 4, p. 408-411 4 p.Research output: Contribution to journal › Article › peer-review
18 Citations (Scopus) -
1993
Cyclosporin a toxicity in children
Crocker, J. F. S., Dempsey, T., Schenk, M. E. & Renton, K. W., Apr 1993, In: Transplantation Reviews. 7, 2, p. 72-81 10 p.Research output: Contribution to journal › Article › peer-review
9 Citations (Scopus) -
Dissociation of xanthine oxidase induction and cytochrome P450 depression during interferon induction in the rat
Cribb, A. E. & Renton, K. W., Dec 3 1993, In: Biochemical Pharmacology. 46, 11, p. 2114-2117 4 p.Research output: Contribution to journal › Article › peer-review
22 Citations (Scopus) -
Erratum: (Molecular Pharmacology (April 1993) 43:4 (542-547))
Armstrong, S. G. & Renton, K. W., 1993, In: Molecular Pharmacology. 44, 3, p. 677 1 p.Research output: Contribution to journal › Comment/debate › peer-review
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Hepatic cytochrome P450 and related drug biotransformation during an outbreak of mouse hepatitis virus in a colony of Swiss BALB/c mice
Armstrong, S. & Renton, K. W., 1993, In: Canadian Journal of Physiology and Pharmacology. 71, 2, p. 188-190 3 p.Research output: Contribution to journal › Article › peer-review
3 Citations (Scopus) -
Mechanism of hepatic cytochrome P450 modulation during Listeria monocytogenes infection in mice
Armstrong, S. G. & Renton, K. W., 1993, In: Molecular Pharmacology. 43, 4, p. 542-547 6 p.Research output: Contribution to journal › Article › peer-review
34 Citations (Scopus)