Research output per year
Research output per year
- 1 - 50 out of 78 results
Search results
-
2019
HDAC6 differentially regulates autophagy in stem-like versus differentiated cancer cells
Sharif, T., Martell, E., Dai, C., Ghassemi-Rad, M. S., Hanes, M. R., Murphy, P. J., Margam, N. N., Parmar, H. B., Giacomantonio, C. A., Duncan, R., Lee, P. W. K. & Gujar, S., Apr 3 2019, In: Autophagy. 15, 4, p. 686-706 21 p.Research output: Contribution to journal › Article › peer-review
Open Access33 Citations (Scopus) -
Regulation of cancer and cancer-related genes via NAD +
Sharif, T., Martell, E., Dai, C., Ghassemi-Rad, M. S., Kennedy, B. E., Lee, P. W. K. & Gujar, S., 2019, In: Antioxidants and Redox Signaling. 30, 6, p. 903-923 21 p.Research output: Contribution to journal › Review article › peer-review
20 Citations (Scopus) -
Retraction: DNA-PKCS binding to p53 on the p21WAF1/CIP1 promoter blocks transcription resulting in cell death (Oncotarget (2011) 2 (1094–1108) DOI: 10.18632/oncotarget.378)
Hill, R., Madureira, P. A., Waisman, D. M. & Lee, P. W. K., 2019, In: Oncotarget. 10, 53, p. 5572 1 p.Research output: Contribution to journal › Comment/debate › peer-review
Open Access2 Citations (Scopus) -
2018
Antitumor Benefits of Antiviral Immunity: An Underappreciated Aspect of Oncolytic Virotherapies
Gujar, S., Pol, J. G., Kim, Y., Lee, P. W. & Kroemer, G., Mar 2018, In: Trends in Immunology. 39, 3, p. 209-221 13 p.Research output: Contribution to journal › Review article › peer-review
168 Citations (Scopus) -
Potentiating prostate cancer immunotherapy with oncolytic viruses
Lee, P. & Gujar, S., Apr 1 2018, In: Nature Reviews Urology. 15, 4, p. 235-250 16 p.Research output: Contribution to journal › Review article › peer-review
52 Citations (Scopus) -
2017
Autophagic homeostasis is required for the pluripotency of cancer stem cells
Sharif, T., Martell, E., Dai, C., Kennedy, B. E., Murphy, P., Clements, D. R., Kim, Y., Lee, P. W. K. & Gujar, S. A., Feb 1 2017, In: Autophagy. 13, 2, p. 264-284 21 p.Research output: Contribution to journal › Article › peer-review
Open Access118 Citations (Scopus) -
MHC-I Ligand Discovery Using Targeted Database Searches of Mass Spectrometry Data: Implications for T-Cell Immunotherapies
Murphy, J. P., Konda, P., Kowalewski, D. J., Schuster, H., Clements, D., Kim, Y., Cohen, A. M., Sharif, T., Nielsen, M., Stevanovic, S., Lee, P. W. & Gujar, S., Apr 7 2017, In: Journal of Proteome Research. 16, 4, p. 1806-1816 11 p.Research output: Contribution to journal › Article › peer-review
Open Access41 Citations (Scopus) -
Quantitative Temporal in Vivo Proteomics Deciphers the Transition of Virus-Driven Myeloid Cells into M2 Macrophages
Clements, D. R., Murphy, J. P., Sterea, A., Kennedy, B. E., Kim, Y., Helson, E., Almasi, S., Holay, N., Konda, P., Paulo, J. A., Sharif, T., Lee, P. W., Weekes, M. P., Gygi, S. P. & Gujar, S., Sept 1 2017, In: Journal of Proteome Research. 16, 9, p. 3391-3406 16 p.Research output: Contribution to journal › Article › peer-review
Open Access14 Citations (Scopus) -
Sharpening the edge for precision cancer immunotherapy: Targeting tumor antigens through oncolytic vaccines
Holay, N., Kim, Y., Lee, P. & Gujar, S., Jul 13 2017, In: Frontiers in Immunology. 8, JUL, 800.Research output: Contribution to journal › Short survey › peer-review
Open Access15 Citations (Scopus) -
Virus-infected human mast cells enhance natural killer cell functions
Portales-Cervantes, L., Haidl, I. D., Lee, P. W. & Marshall, J. S., Jan 1 2017, In: Journal of Innate Immunity. 9, 1, p. 94-108 15 p.Research output: Contribution to journal › Article › peer-review
Open Access26 Citations (Scopus) -
2016
All that glitters is not gold: The need to consider desirable and undesirable immune aspects of oncolytic virus therapy
Clements, D. R., Kim, Y., Gujar, S. A. & Lee, P. W. K., 2016, In: OncoImmunology. 5, 1Research output: Contribution to journal › Article › peer-review
Open Access8 Citations (Scopus) -
Breast cancer subtype dictates DNA methylation and ALDH1A3-mediated expression of tumor suppressor RARRES1
Coyle, K. M., Murphy, J. P., Vidovic, D., Vaghar-Kashani, A., Dean, C. A., Sultan, M., Clements, D., Wallace, M., Thomas, M. L., Hundert, A., Giacomantonio, C. A., Helyer, L., Gujar, S. A., Lee, P. W. K., Weaver, I. C. G. & Marcato, P., 2016, In: Oncotarget. 7, 28, p. 44096-44112 17 p.Research output: Contribution to journal › Article › peer-review
Open Access26 Citations (Scopus) -
Cell surface protease activation during RAS transformation: Critical role of the plasminogen receptor, S100A10
Madureira, P. A., Bharadwaj, A. G., Bydoun, M., Garant, K., O'Connell, P., Lee, P. & Waisman, D. M., 2016, In: Oncotarget. 7, 30, p. 47720-47737 18 p.Research output: Contribution to journal › Article › peer-review
Open Access18 Citations (Scopus) -
Erratum: Subversion of Autophagy by Kaposi's Sarcoma-Associated Herpesvirus Impairs Oncogene-Induced Senescence (Cell Host and Microbe (2012) 11 (167180))
Leidal, A. M., Cyr, D. P., Hill, R. J., Lee, P. W. K. & McCormick, C., Jun 8 2016, In: Cell Host and Microbe. 19, 6, p. 901 1 p.Research output: Contribution to journal › Comment/debate › peer-review
Open Access5 Citations (Scopus) -
NAD+ salvage pathway in cancer metabolism and therapy
Kennedy, B. E., Sharif, T., Martell, E., Dai, C., Kim, Y., Lee, P. W. K. & Gujar, S. A., Dec 1 2016, In: Pharmacological Research. 114, p. 274-283 10 p.Research output: Contribution to journal › Review article › peer-review
114 Citations (Scopus) -
The NAD+ salvage pathway modulates cancer cell viability via p73
Sharif, T., Ahn, D. G., Liu, R. Z., Pringle, E., Martell, E., Dai, C., Nunokawa, A., Kwak, M., Clements, D., Murphy, J. P., Dean, C., Marcato, P., McCormick, C., Godbout, R., Gujar, S. A. & Lee, P. W. K., Apr 1 2016, In: Cell Death and Differentiation. 23, 4, p. 669-680 12 p.Research output: Contribution to journal › Article › peer-review
Open Access55 Citations (Scopus) -
2015
Aggregation of nanoparticles in endosomes and lysosomes produces surface-enhanced Raman spectroscopy
Lucas, L. J., Chen, X. K., Smith, A. J., Korbelik, M., Zeng, H., Lee, P. W. K. & Hewitt, K. C., Jan 1 2015, In: Journal of Nanophotonics. 9, 1, 093094.Research output: Contribution to journal › Article › peer-review
Open Access10 Citations (Scopus) -
Aldehyde dehydrogenase 1A3 influences breast cancer progression via differential retinoic acid signaling
Marcato, P., Dean, C. A., Liu, R. Z., Coyle, K. M., Bydoun, M., Wallace, M., Clements, D., Turner, C., Mathenge, E. G., Gujar, S. A., Giacomantonio, C. A., Mackey, J. R., Godbout, R. & Lee, P. W. K., Jan 1 2015, In: Molecular Oncology. 9, 1, p. 17-31 15 p.Research output: Contribution to journal › Article › peer-review
Open Access98 Citations (Scopus) -
Dendritic cells in oncolytic virus-based anti-cancer therapy
Kim, Y., Clements, D. R., Sterea, A. M., Jang, H. W., Gujar, S. A. & Lee, P. W. K., Dec 9 2015, In: Viruses. 7, 12, p. 6506-6525 20 p.Research output: Contribution to journal › Review article › peer-review
Open Access31 Citations (Scopus) -
Newly recruited CD11b+, GR-1+, Ly6Chigh myeloid cells augment tumor-associated immunosuppression immediately following the therapeutic administration of oncolytic reovirus
Clements, D. R., Sterea, A. M., Kim, Y., Helson, E., Dean, C. A., Nunokawa, A., Coyle, K. M., Sharif, T., Marcato, P., Gujar, S. A. & Lee, P. W. K., May 1 2015, In: Journal of Immunology. 194, 9, p. 4397-4412 16 p.Research output: Contribution to journal › Article › peer-review
Open Access30 Citations (Scopus) -
Ras transformation results in cleavage of reticulon protein Nogo-B that is associated with impairment of IFN response
Ahn, D. G., Sharif, T., Chisholm, K., Pinto, D. M., Gujar, S. A. & Lee, P. W. K., Jan 1 2015, In: Cell Cycle. 14, 14, p. 2301-2310 10 p.Research output: Contribution to journal › Article › peer-review
Open Access13 Citations (Scopus) -
2014
Core Needle Biopsy of Breast Cancer Tumors Increases Distant Metastases in a Mouse Model
Mathenge, E. G., Dean, C. A., Clements, D., Vaghar-Kashani, A., Photopoulos, S., Coyle, K. M., Giacomantonio, M., Malueth, B., Nunokawa, A., Jordan, J., Lewis, J. D., Gujar, S. A., Marcato, P., Lee, P. W. K. & Giacomantonio, C. A., 2014, In: Neoplasia. 16, 11, p. 950-960 11 p.Research output: Contribution to journal › Article › peer-review
Open Access76 Citations (Scopus) -
Gemcitabine enhances the efficacy of reovirus-based oncotherapy through anti-tumour immunological mechanisms
Gujar, S. A., Clements, D., Dielschneider, R., Helson, E., Marcato, P. & Lee, P. W. K., 2014, In: British Journal of Cancer. 110, 1, p. 83-93 11 p.Research output: Contribution to journal › Article › peer-review
Open Access52 Citations (Scopus) -
Oncolytic virus-mediated reversal of impaired tumor antigen presentation
Gujar, S. A. & Lee, P. W. K., 2014, In: Frontiers in Oncology. 4 APR, Article 77.Research output: Contribution to journal › Article › peer-review
Open Access50 Citations (Scopus) -
The NAD+ synthesizing enzyme nicotinamide mononucleotide adenylyltransferase 2 (NMNAT-2) is a p53 downstream target
Pan, L. Z., Ahn, D. G., Sharif, T., Clements, D., Gujar, S. A. & Lee, P. W. K., Mar 15 2014, In: Cell Cycle. 13, 6, p. 1041-1048 8 p.Research output: Contribution to journal › Article › peer-review
Open Access31 Citations (Scopus) -
Two is better than one: Complementing oncolytic virotherapy with gemcitabine to potentiate antitumor immune responses
Gujar, S. A., Clements, D. & Lee, P. W. K., 2014, In: OncoImmunology. 3, 1, e27622.Research output: Contribution to journal › Article › peer-review
Open Access18 Citations (Scopus) -
2013
Activation of p53 by Chemotherapeutic Agents Enhances Reovirus Oncolysis
Pan, D., Marcato, P., Ahn, D. G., Gujar, S., Pan, L. Z., Shmulevitz, M. & Lee, P. W. K., Jan 16 2013, In: PLoS One. 8, 1, e54006.Research output: Contribution to journal › Article › peer-review
Open Access19 Citations (Scopus) -
Gemcitabine-mediated tumour regression and p53-dependent gene expression: Implications for colon and pancreatic cancer therapy
Hill, R., Rabb, M., Madureira, P. A., Clements, D., Gujar, S. A., Waisman, D. M., Giacomantonio, C. A. & Lee, P. W. K., Sept 2013, In: Cell Death and Disease. 4, 9, e791.Research output: Contribution to journal › Article › peer-review
Open Access52 Citations (Scopus) -
Multifaceted therapeutic targeting of ovarian peritoneal carcinomatosis through virus-induced immunomodulation
Gujar, S., Dielschneider, R., Clements, D., Helson, E., Shmulevitz, M., Marcato, P., Pan, D., Pan, L. Z., Ahn, D. G., Alawadhi, A. & Lee, P. W. K., Feb 2013, In: Molecular Therapy. 21, 2, p. 338-347 10 p.Research output: Contribution to journal › Article › peer-review
Open Access64 Citations (Scopus) -
2012
Genotoxic Agents Promote the Nuclear Accumulation of Annexin A2: Role of Annexin A2 in Mitigating DNA Damage
Madureira, P. A., Hill, R., Lee, P. W. K. & Waisman, D. M., Nov 30 2012, In: PLoS One. 7, 11, e50591.Research output: Contribution to journal › Article › peer-review
Open Access39 Citations (Scopus) -
Pro-oncogenic cell signaling machinery as a target for oncolytic viruses
Borrego-Diaz, E., Mathew, R., Hawkinson, D., Esfandyari, T., Liu, Z., Lee, P. W. & Farassati, F., Jul 2012, In: Current Pharmaceutical Biotechnology. 13, 9, p. 1742-1749 8 p.Research output: Contribution to journal › Article › peer-review
7 Citations (Scopus) -
Reovirus variants with mutations in genome segments S1 and L2 exhibit enhanced virion infectivity and superior oncolysis
Shmulevitz, M., Gujar, S. A., Ahn, D. G., Mohamed, A. & Lee, P. W. K., Jul 2012, In: Journal of Virology. 86, 13, p. 7403-7413 11 p.Research output: Contribution to journal › Article › peer-review
27 Citations (Scopus) -
Subversion of autophagy by Kaposi's sarcoma-associated herpesvirus impairs oncogene-induced senescence
Leidal, A. M., Cyr, D. P., Hill, R. J., Lee, P. W. K. & McCormick, C., Feb 16 2012, In: Cell Host and Microbe. 11, 2, p. 167-180 14 p.Research output: Contribution to journal › Article › peer-review
Open Access94 Citations (Scopus) -
Viral subversion of autophagy impairs oncogene-induced senescence
Leidal, A. M., Lee, P. W. K. & McCormick, C., Jul 2012, In: Autophagy. 8, 7, p. 1138-1140 3 p.Research output: Contribution to journal › Short survey › peer-review
Open Access8 Citations (Scopus) -
2011
Aldehyde dehydrogenase activity of breast cancer stem cells is primarily due to isoform ALDH1A3 and its expression is predictive of metastasis
Marcato, P., Dean, C. A., Da, P., Araslanova, R., Gillis, M., Joshi, M., Helyer, L., Pan, L., Leidal, A., Gujar, S., Giacomantonio, C. A. & Lee, P. W. K., Jan 2011, In: Stem Cells. 29, 1, p. 32-45 14 p.Research output: Contribution to journal › Article › peer-review
391 Citations (Scopus) -
Aldehyde dehydrogenase its role as a cancer stem cell marker comes down to the specific isoform
Marcato, P., Dean, C. A., Giacomantonio, C. A. & Lee, P. W. K., May 1 2011, In: Cell Cycle. 10, 9, p. 1378-1384 7 p.Research output: Contribution to journal › Review article › peer-review
Open Access430 Citations (Scopus) -
Annexin A2 is a novel cellular redox regulatory protein involved in tumorigenesis
Madureira, P. A., Hill, R., Miller, V. A., Giacomantonio, C., Lee, P. W. K. & Waisman, D. M., Dec 2011, In: Oncotarget. 2, 12, p. 1075-1093 19 p.Research output: Contribution to journal › Article › peer-review
Open Access75 Citations (Scopus) -
Attenuated reovirus displays oncolysis with reduced host toxicity
Kim, M., Garant, K. A., Zur Nieden, N. I., Alain, T., Loken, S. D., Urbanski, S. J., Forsyth, P. A., Rancourt, D. E., Lee, P. W. K. & Johnston, R. N., Jan 18 2011, In: British Journal of Cancer. 104, 2, p. 290-299 10 p.Research output: Contribution to journal › Article › peer-review
Open Access38 Citations (Scopus) -
DNA-PKCS binding to p53 on the p21WAF1/CIP1 promoter blocks transcription resulting in cell death
Hill, R., Madureira, P. A., Waisman, D. M. & Lee, P. W. K., Dec 2011, In: Oncotarget. 2, 12, p. 1094-1108 15 p.Research output: Contribution to journal › Article › peer-review
Open Access38 Citations (Scopus) -
Oncolytic virus-initiated protective immunity against prostate cancer
Gujar, S. A., Pan, D., Marcato, P., Garant, K. A. & Lee, P. W. K., Apr 2011, In: Molecular Therapy. 19, 4, p. 797-804 8 p.Research output: Contribution to journal › Article › peer-review
Open Access71 Citations (Scopus) -
Stabilisation of p53 enhances reovirus-induced apoptosis and virus spread through p53-dependent NF-κB activation
Pan, D., Pan, L. Z., Hill, R., Marcato, P., Shmulevitz, M., Vassilev, L. T. & Lee, P. W. K., Sept 27 2011, In: British Journal of Cancer. 105, 7, p. 1012-1022 11 p.Research output: Contribution to journal › Article › peer-review
Open Access37 Citations (Scopus) -
2010
Activated Ras signaling significantly enhances reovirus replication and spread
Shmulevitz, M., Marcato, P. & Lee, P. W. K., Jan 2010, In: Cancer Gene Therapy. 17, 1, p. 69-70 2 p.Research output: Contribution to journal › Letter › peer-review
23 Citations (Scopus) -
Curcumin causes superoxide anion production and p53-independent apoptosis in human colon cancer cells
Watson, J. L., Hill, R., Yaffe, P. B., Greenshields, A., Walsh, M., Lee, P. W., Giacomantonio, C. A. & Hoskin, D. W., Nov 2010, In: Cancer Letters. 297, 1, p. 1-8 8 p.Research output: Contribution to journal › Article › peer-review
127 Citations (Scopus) -
Curcumin-induced apoptosis in ovarian carcinoma cells is p53-independent and involves p38 mitogen-activated protein kinase activation and downregulation of Bcl-2 and survivin expression and akt signaling
Watson, J. L., Greenshields, A., Hill, R., Hilchie, A., Lee, P. W., Giacomantonio, C. A. & Hoskin, D. W., Jan 2010, In: Molecular Carcinogenesis. 49, 1, p. 13-24 12 p.Research output: Contribution to journal › Article › peer-review
127 Citations (Scopus) -
Oncogenic Ras promotes reovirus spread by suppressing IFN-β production through negative regulation of RIG-I signaling
Shmulevitz, M., Pan, L. Z., Garant, K., Pan, D. & Lee, P. W. K., Jun 15 2010, In: Cancer Research. 70, 12, p. 4912-4921 10 p.Research output: Contribution to journal › Article › peer-review
81 Citations (Scopus) -
Oncolytic viral therapy for prostate cancer: Efficacy of reovirus as a biological therapeutic
Thirukkumaran, C. M., Nodwell, M. J., Hirasawa, K., Shi, Z. Q., Diaz, R., Luider, J., Johnston, R. N., Forsyth, P. A., Magliocco, A. M., Lee, P., Nishikawa, S., Donnelly, B., Coffey, M., Trpkov, K., Fonseca, K., Spurrell, J. & Morris, D. G., Mar 15 2010, In: Cancer Research. 70, 6, p. 2435-2444 10 p.Research output: Contribution to journal › Article › peer-review
Open Access78 Citations (Scopus) -
Reovirus virotherapy overrides tumor antigen presentation evasion and promotes protective antitumor immunity
Gujar, S. A., Marcato, P., Pan, D. & Lee, P. W. K., Nov 2010, In: Molecular Cancer Therapeutics. 9, 11, p. 2924-2933 10 p.Research output: Contribution to journal › Article › peer-review
90 Citations (Scopus) -
The DNA-dependent protein kinase (DNA-PK): More than just a case of making ends meet?
Hill, R. & Lee, P. W. K., Sept 1 2010, In: Cell Cycle. 9, 17, p. 3460-3469 10 p.Research output: Contribution to journal › Review article › peer-review
Open Access84 Citations (Scopus) -
The viral tropism of two distinct oncolytic viruses, reovirus and myxoma virus, is modulated by cellular tumor suppressor gene status
Kim, M., Williamson, C. T., Prudhomme, J., Bebb, D. G., Riabowol, K., Lee, P. W. K., Lees-Miller, S. P., Mori, Y., Rahman, M. M., McFadden, G. & Johnston, R. N., Jul 8 2010, In: Oncogene. 29, 27, p. 3990-3996 7 p.Research output: Contribution to journal › Article › peer-review
52 Citations (Scopus) -
Z-FA-FMK as a novel potent inhibitor of reovirus pathogenesis and oncolysis in vivo
Kim, M., Hansen, K. K., Davis, L., Van Marle, G., Gill, M. J., Fox, J. D., Hollenberg, M. D., Rancourt, D. E., Lee, P. W. K., Yun, C. O. & Johnston, R. N., 2010, In: Antiviral Therapy. 15, 6, p. 897-905 9 p.Research output: Contribution to journal › Article › peer-review
14 Citations (Scopus)